Effects of eye removal at birth on histogenesis of the mouse superior colliculus: An autoradiographic analysis with tritiated thymidine

Gr, Delong; Rl, Sidman

doi:10.1002/cne.901180207

Cited by 131 publications

(16 citation statements)

References 34 publications

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“…The reduction in the cross section of the colliculus ipsilateral to the enucleated eye was estimated in a manner similar to that employed by DeLong & Sidman (1962). In four neonatally enucleated hamsters pictures of coronal sections were taken at 100 pm intervals.…”

Section: Methodsmentioning

confidence: 99%

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Effects of neonatal enucleation on the functional organization of the superior colliculus in the golden hamster.

Rhoades¹

1980

The Journal of Physiology

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SUMMARY1. The responses of visual, auditory and somatosensory superior collicular neurones were investigated using extracellular single unit recording techniques in hamsters which were subjected to the removal of one eye on the day of birth.2. Neonatal enucleation resulted in a marked increase in the region of the colliculus from which visual neurones activated by stimulation of the ipsilateral eye could be recorded. In most cases the visuotopic representation in the colliculus ipsilateral to the remaining eye mirrored that observed in the contralateral tectum along both the rostrocaudal and mediolateral axes: in both colliculi temporal retina projected rostrally and inferior retina medially. In some animals, however, there appeared to be a dual mapping of the remaining eye onto the ipsilateral tectum. In these hamsters the central portion of the visual field was represented twice along the rostrocaudal axis of colliculus.3. No changes in the topography ofthe somatosensory and auditory representations in the tectum were observed following neonatal enucleation.4. The laminar distribution of visual neurones in the ipsilateral colliculus was markedly altered in the neonatally enucleated hamsters. Very few exclusively visual units were encountered in the layers ventral to the stratum opticum and almost all of the visual cells recorded in the ipsilateral colliculus were isolated within 150 gm of the tectal surface.5. In the posterior half of the ipsilateral tectum a large number of extravisually responsive cells were encountered in the stratum griseum superficiale and stratum opticum. This was not the case in the colliculus contralateral to the remaining eye, nor has it ever been observed in normal hamsters. 6. Recordings from animals subjected to both neonatal enucleation and acute bilateral removal of somatosensory and auditory cortex indicated that the projections from these areas to the colliculus were not essential to the observed changes in laminar organization.7. Recordings from normally reared hamsters which were subjected to removal of one eye at the time of the recording experiment suggested further that the isolation of extravisual cells in the superficial tectal laminae of the neonatal enucleates was probably not the result of the 'unmasking' of extravisual influences in the superficial layers which are present, but ineffective, in the normal case.

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Section: Methodsmentioning

confidence: 99%

“…It has been demonstrated that eye removal in the developing mouse (DeLong & Sidman, 1962) or rat (Lund, Cunningham & Lund, 1973;Tsang, 1937) results in an appreciable reduction in collicular volume. As can be seen in P1.…”

Section: Rwrhoades Neonatal Enucleation and Hamster Colliculus 393mentioning

confidence: 99%

Effects of neonatal enucleation on the functional organization of the superior colliculus in the golden hamster.

Rhoades¹

1980

The Journal of Physiology

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“…This has previously been most clearly demonstrated in studies in which peripheral sense organs have been removed. For example, removal of the eye in newborn mice is followed by a massive degeneration of the superior colliculus (DeLong and Sidman, 1962) and lateral geniculate (Heumann and Rabinowicz, 1980). Thus, when studying the mechanisms underlying cell death among neurons as a consequence of normal development or after early lesions, it seems necessary to consider an interaction between the target and the afferent input in control of the cell death process (see, e.g., Linden, 1994).…”

Section: Contribution Of Afferent Input and Target Neurons To Internementioning

confidence: 98%

Apoptosis of spinal interneurons induced by sciatic nerve axotomy in the neonatal rat is counteracted by nerve growth factor and ciliary neurotrophic factor

Oliveira

Risling

Negro

et al. 2002

J of Comparative Neurology

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We have previously shown that not only motoneurons and dorsal root ganglion cells but also small neurons, presumably interneurons in the spinal cord, may undergo apoptotic cell death as a result of neonatal peripheral nerve transection in the rat. With the aid of electron microscopy, we have here demonstrated that apoptosis in the spinal cord is confined to neurons and does not involve glial cells at the survival time studied (24 hours). To define the relative importance of the loss of a potential target (motoneuron) and a potential afferent input (dorsal root ganglion cell) for the induction of apoptosis in interneurons in this situation, we have compared the distributions and time courses for TUNEL labeling, which detects apoptotic cell nuclei, in the L5 segment of the spinal cord and the L5 dorsal root ganglion after sciatic nerve transection in the neonatal (P2) rat. In additional experiments, we studied the effects on TUNEL labeling of interneurons after treatment of the cut sciatic nerve with either ciliary neurotrophic factor (CNTF) to rescue motoneurons or nerve growth factor (NGF) to rescue dorsal root ganglion cells. The time courses of the TUNEL labeling in motoneurons and interneurons induced by the lesion show great similarities (peak at 8-48 hours postoperatively), whereas the labeling in dorsal root ganglion cells occurs later (24-72 hours). Both CNTF and NGF decrease the number of TUNEL-labeled interneurons, but there is a regional difference, in that CNTF preferentially saves interneurons in deep dorsal and ventral parts of the spinal cord, whereas the rescuing effects of NGF are seen mainly in the superficial dorsal horn. The results are interpreted as signs of a trophic dependence on both the target and the afferent input for the survival of interneurons neonatally.

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“…1959], and since it is well known that neuron production is generally limited only to a certain period in embryonic development and that the neuronal population of the central nervous system becomes static after birth [Nurnberger and G ordon, 1957;F ujita andTakeoka. 1961: Hicks et at., 1962;DeLong and Sigman, 1962;Brizzee et al, 1964], The increase in the ratio, therefore, would be attributed to the actual increase in the number of glial cells. It is also apparent from the results presented in table I that the ratio becomes constant after day 22 and, therefore, the glial production in the spinal cord must have stabilized soon after this age.…”

Section: Generalmentioning

confidence: 99%

Study in the changes of the proportions and numbers of the various glial cell types in the spinal cord of neonatal and young adult rats

Ling¹

1976

Cells Tissues Organs

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Glioblasts, astrocytes, microglia and the three classes of oligodendrocytes were enumerated in the grey and white matter of the spinal cord of rats of various ages. Both regions showed fairly similar results. Glioblasts, which made up the major glial population in the newborn rats, declined steadily with age and their number became negligible by 22 days post natum. They were absent in the young adult rats (aged 70 days). Contrary to this, the major glial types increased rapidly with age, the increase being most drastic in the oligodendrocy tic population. The growth continued through about 22 days after birth and became more or less stabilized thereafter. Of the three classes of oligodendrocytes, the light cells appeared to develop first, followed by the medium dense cells and subsequently the dark ones. While there was a gradual disappearance of the light and medium dense cells with age, there was an accumulation of the dark cells, so that they were predominant in the spinal cord of the young adult rats.

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Effects of eye removal at birth on histogenesis of the mouse superior colliculus: An autoradiographic analysis with tritiated thymidine

Cited by 131 publications

References 34 publications

Effects of neonatal enucleation on the functional organization of the superior colliculus in the golden hamster.

Effects of neonatal enucleation on the functional organization of the superior colliculus in the golden hamster.

Apoptosis of spinal interneurons induced by sciatic nerve axotomy in the neonatal rat is counteracted by nerve growth factor and ciliary neurotrophic factor

Study in the changes of the proportions and numbers of the various glial cell types in the spinal cord of neonatal and young adult rats

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