A study was conducted at the National Semi-Arid Resources Research Institute-Serere, Uganda for three seasons (2013 short rains, 2014 long rains and 2014 short rains) to investigate the effect of crop residues and animal manure on soil bulk density (SBD), soil moisture content (SMC) and water use efficiency (WUE) of sesame. The experiment was laid out in a randomized complete block design with three replications. The treatments comprised: control, 4 crop residues, 2 animal manures and combinations of 2 animal manures and 4 crop residues all applied at two rates of 3 and 6 t/ha. Plots treated with 6 t/ha of millet husks produced the highest SMC (37.46%) and lowest SBD (1.1717 g/cm 3 ) across seasons; while plots treated with 3 t/ha of millet husks produced the highest WUE of sesame (9.92 kg ha -1 mm -1 ) across seasons compared with other crop residue and animal manure treatments applied singly. Soil moisture content was highest (38.09%) and SBD lowest (1.0520 g/cm 3 ) across seasons in plots treated with 6 t/ha of poultry manure plus millet husks; while plots amended with 3 t/ha of poultry manure plus millet husks produced the highest WUE of sesame (9.40 g/cm 3 ) across seasons compared with other treatments. Crop residues influenced SMC and SBD in the order; millet husks > cowpea husks > sorghum husks > groundnut shells. Crop residues affected WUE of sesame in the order; millet husks > sorghum husks > groundnut shells > cowpea husks. This study has demonstrated that poultry manure plus millet husks have a potential to enhance WUE of sesame.