Effects of fast food packaging plasticizers and their metabolites on steroid hormone synthesis in H295R cells

Duan, Chenhui; Fang, Yanjun; Sun, Jiangman; Li, Zhenxin; Wang, Qiangqiang; Bai, Jintao; Peng, Hui; Liang, Jun; Gao, Zhixian

doi:10.1016/j.scitotenv.2020.138500

Cited by 26 publications

(17 citation statements)

References 49 publications

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“…Phthalates Diethlyhexylphthalate (DEHP),Dibutylphthalate (DBP) DEHP Plasticizesr in polyvinyl chloride polymers (PVC); found in wires, plastic bottles, medical equipment, lacquers, varnishes, paints, fixatives in perfumes, insect repellents Androgen, glucocorticoid, progestogen activity [43]; PPARγ affinity [46]; disrupted expression of potassium channels [49], AGTR1a/b, LDL-R [50]; differentially activated transcription factors [54]; ↑ DNA methylation [44]; cholesterol synthesis [50]; disrupted expression of StAR, CYP, HSD [60][61][62];…”

Section: Bisphenolsmentioning

confidence: 99%

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Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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Endocrine-disrupting chemicals (EDCs) are exogenous substances known to interfere with endocrine homeostasis and promote adverse health outcomes. Their impact on the adrenal cortex, corticosteroids and their physiological role in the organism has not yet been sufficiently elucidated. In this review, we collect experimental and epidemiological evidence on adrenal disruption by relevant endocrine disruptors. In vitro data suggest significant alterations of gene expression, cell signalling, steroid production, steroid distribution, and action. Additionally, morphological studies revealed disturbances in tissue organization and development, local inflammation, and zone-specific hyperplasia. Finally, endocrine circuits, such as the hypothalamic-pituitary-adrenal axis, might be affected by EDCs. Many questions regarding the detection of steroidogenesis disruption and the effects of combined toxicity remain unanswered. Not only due to the diverse mode of action of adrenal steroids and their implication in many common diseases, there is no doubt that further research on endocrine disruption of the adrenocortical system is needed.

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Section: Bisphenolsmentioning

confidence: 99%

“…phthalates [60][61][62], bisphenols [63,64], PFAS, or PCBs [48]. In silico analyses demonstrated direct inhibitory effects of phthalates on CYP450 enzymes involved in steroidogenesis via molecular docking.…”

Section: Steroidogenic Enzyme Expressionmentioning

confidence: 99%

Endocrine Disruptors: Focus on the Adrenal Cortex

Pötzl,

Kürzinger,

Stopper

et al. 2023

Horm Metab Res

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show abstract

“…Human health is at risk, a proven fact by scientific studies that presented that plastics can induce carcinogenesis in humans [2]. Plasticizers such as DEHP, DBP, DEHA, and their metabolites have migrated, especially from fast food packaging materials to foods that, even at low concentrations, can cause endocrinedisrupting effects [60]. For this reason, researchers are focused on studying the use of plasticizers with biodegradable films for ecofriendly food packaging applications [61] and alternative plasticizers safer for human health [62]; however, MP/NP migration is an important problem that still remains a strong research question.…”

Section: Genericmentioning

confidence: 99%

“…In a related article, it was shown that dynamic viscosity was affected by the heating of raw rape honey at various temperatures (30,40,50,60,70, and 80 • C). The viscosity after 20 • C started to significantly decrease at 30, 40, and 50 • C for all individual samples.…”

Section: Viscosity/heatmentioning

confidence: 99%

Honey Quality and Microplastic Migration from Food Packaging: A Potential Threat for Consumer Health?

et al. 2022

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In ancient Greece, people said that “honey is the Food of the Gods”, and they were right. They believed that honey fell from the sky, with the morning dew, on the flowers and leaves, and from this point, the bees collected it. Honey is one of the most nutritious food products, which can be found in most homes. A lot of honey products are stored in different types of packaging materials, including plastics. Plastic packaging has been studied for the migration of plasticizers, chemical compounds, and MPs and NPs in foodstuffs. Most of them have been achieved through food simulations, while some studies managed to detect and isolate MPs/NPs. Recent studies presented evidence for the presence of MPs/NPs in honey products but not directly connected to food packaging or to the different types of honey and their properties (viscosity, pH value, and moisture content) or their storing conditions (temperature, humidity, light, and time). Spectroscopic and analytical techniques like Raman, FTIR, HPLC, and GC-MS are in the foreground for MP/NP detection and identification, but a universal way of isolation, detection, characterization, and quantification has not yet been found. This leaves an open field for more work to be done to clarify the factors affecting the migration of plastic packaging material in honey.

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“…Another group of plasticisers with increasing use are the adipates, this class of plasticisers has been much less studied but recent findings showed that bis (2-ethylhexyl) adipate (DEHA) and their metabolites can cause, even at low concentrations, endocrine-disrupting effects on the steroid hormone synthesis in H295R cell ( Duan et al, 2020 ).…”

Section: Pathways Of Plastic Additive Toxicitymentioning

confidence: 99%

Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests

Llorca

Farré

2021

Front. Toxicol.

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Humans are exposed to micro and nanoplastics (MNPLs) through inhalation, ingestion and, to a lesser extent, dermal contact. In recent years, new insights indicate the potential of MNPLs to cause damages to human health. Particle toxicity can include oxidative stress, inflammatory lesions, and then increased internalization or translocation through tissues. On the other hand, plastic additives are used in plastic particles, once internalized, can release toxic substances. It is noteworthy that the potential effects of MNPLs encompass a wide range of polymers and chemical additives, showing various physicochemical and toxicological properties, and the size, shape and surface properties are other variables influencing their effects. In spite of the research carried out recently, MNPLs research is in its early stages, and further investigation is required. In this review article, the knowledge of human exposure routes and the recent results on the toxicological effects of MNPLs in human health are presented and discussed. Finally, the current limitations and the main gaps in the body of knowledge are summarised.

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Effects of fast food packaging plasticizers and their metabolites on steroid hormone synthesis in H295R cells

Cited by 26 publications

References 49 publications

Endocrine Disruptors: Focus on the Adrenal Cortex

Endocrine Disruptors: Focus on the Adrenal Cortex

Honey Quality and Microplastic Migration from Food Packaging: A Potential Threat for Consumer Health?

Current Insights into Potential Effects of Micro-Nanoplastics on Human Health by in-vitro Tests

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