Effects of fasting on FOXO3 expression as an anti-aging biomarker in the liver

Hardiany, Novi Silvia; Putra, Muhammad Alifian Remifta; Penantian, Raya Makarim; Antarianto, Radiana Dhewayani

doi:10.1016/j.heliyon.2023.e13144

Cited by 4 publications

(1 citation statement)

References 45 publications

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“…Ketone bodies produced during IF-induced metabolic switching exhibit antioxidative effects by upregulating the transcription of genes, including antioxidant enzymes (superoxide dismutase [SOD]-1, SOD2, and catalase) and FoxO, which mediate the protective actions of sirtuins (Sirts). [54][55][56][57] Robust antioxidant activity, particularly that of MnSOD, is recognized as essential for maintaining a healthy BBB. 58 FoxO3, diminished in endothelial cells under hypoxia, is implicated in BBB damage.…”

Section: Effects Of Intermittent Fasting On Bbb Damage In Vcimentioning

confidence: 99%

Intermittent Metabolic Switching and Vascular Cognitive Impairment

Rajeev,

Tabassum,

Fann

et al. 2024

Journal of Obesity & Metabolic Syndrome

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Intermittent fasting (IF), a dietary pattern alternating between eating and fasting periods within a 24-hour cycle, has garnered recognition for its potential to enhance both healthspan and lifespan in animal models and humans. It also shows promise in alleviating age-related diseases, including neurodegeneration. Vascular cognitive impairment (VCI) spans a severity range from mild cognitive deficits to severe cognitive deficits and loss of function in vascular dementia. Chronic cerebral hypoperfusion has emerged as a significant contributor to VCI, instigating vascular pathologies such as microbleeds, blood-brain barrier dysfunction, neuronal loss and white matter lesions.Preclinical studies in rodents strongly suggest that IF has the potential to attenuate pathological mechanisms, including excitotoxicity, oxidative stress, inflammation, and cell death pathways in VCI models. Hence, this supports evaluating IF in clinical trials for both existing and at-risk VCI patients. This review compiles existing data supporting IF's potential in treating VCI-related vascular and neuronal pathologies, emphasizing the mechanisms by which IF may mitigate these issues. Hence providing a comprehensive overview of the available data supporting IF's potential in treating VCI by emphasizing the underlying mechanisms that make IF a promising intervention for VCI.

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Section: Effects Of Intermittent Fasting On Bbb Damage In Vcimentioning

confidence: 99%

Intermittent Metabolic Switching and Vascular Cognitive Impairment

Rajeev,

Tabassum,

Fann

et al. 2024

Journal of Obesity & Metabolic Syndrome

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Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network

Yang,

Hou,

Zhao

et al. 2023

Ageing Research Reviews

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Role of Intermittent Fasting In Starving Cancer Cells

Sakina,

Meher,

Nath Ravi

et al. 2024

LCB

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Introduction. An absolute burden of over 35 million new cancer cases is predicted by 2050. Although significant progress has been made in the field of oncology via the use of surgical removal, radiation treatment, chemotherapy, and the introduction of immunotherapy, the overall rates of survival and prognoses for cancer patients are still unsatisfactory. In the last decade, intermittent fasting (IF) has become increasingly popular for weight control and potential health benefits. Additionally, research has primarily focused on investigating the impact of IF on metabolism, mitochondrial function, stress responses, repair mechanisms, and autophagy. The aim of the study. To make a literature review about the role of intermittent fasting in starving cancer cells. Materials and methods. This narrative review involved a comprehensive search through databases such as PubMed and Google Scholar. Distinct keywords such as - ″intermittent fasting″, ″intermittent fasting regimens″, ″calorie restriction″, ″oncology″, ″chemotherapy″ and ″tumor microenvironment″ were used. Results. IF exhibits significant impacts on the immune system's ability to fight against tumors by strengthening the ability of hematopoietic stem cells to replenish themselves and enhance immunosuppression. Under an IF program, certain tissues and organs exhibit enhanced resilience to various stressors. Emerging research shows that IF has the potential to enhance the effectiveness and tolerance of anticancer medicines, regulate carcinogenic influences, reprogram clock genes' rhythmic expression in tumor environments, inhibit tumor growth by modifying natural processes like insulin signalling, heme oxygenase-1, prevent the proliferation of myeloid-derived suppressor cells and priming the tumor microenvironment to support drug delivery that targets tumors. Cancer treatment via IF notably shields normal cells while raising the efficacy of chemotherapy (CT) and reducing CT-induced inflammation via several immunological, biochemical, and molecular mechanisms. Conclusions. Regularly practising fasting for more than one day may confer notable health benefits by protecting healthy normal cells against the deleterious effects of chemotherapy and radiation. The synergistic therapeutic impact of intermittent fasting alongside chemotherapy on tumors suggests that it enhances the efficacy of chemotherapy while also notably reducing chemotherapy-induced inflammation. While intermittent fasting shows promise for certain cancers, such as breast cancer, its efficacy for other types remains uncertain, necessitating further research and personalized treatment plans.

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Effects of fasting on FOXO3 expression as an anti-aging biomarker in the liver

Cited by 4 publications

References 45 publications

Intermittent Metabolic Switching and Vascular Cognitive Impairment

Intermittent Metabolic Switching and Vascular Cognitive Impairment

Lifestyle effects on aging and CVD: A spotlight on the nutrient-sensing network

Role of Intermittent Fasting In Starving Cancer Cells

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