Effects of fasting on hematologic and clinical chemical values in cynomolgus monkeys (<i>Macaca fascicularis</i>)

Zeng, Xiancheng; Yang, Chun-Chieh; Pan, Xueying; Yao, Yanmei; Pan, Wen Harn; Zhou, Chenliang; Jiang, Z.-R.; Chang, Yan; Ma, Jianbo

doi:10.1111/j.1600-0684.2010.00444.x

Cited by 17 publications

(11 citation statements)

References 25 publications

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“…Due to the housing conditions, we were able to assure that all monkeys were strictly fasted overnight, because food remains were retrieved after the last feeding schedule. Although it has been previously reported that fasting is not an absolute prerequisite in hematology [21], it could be clinically relevant in monkeys if the fasting duration exceeds 16 h [22]. Therefore, about 16-h fasting duration used in this study might be clinically relevant reference values for NHPs.…”

Section: Discussionmentioning

confidence: 89%

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

et al. 2019

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Nonhuman primate models are valuable in biomedical research. However, reference data for clinical pathology parameters in cynomolgus and rhesus monkeys are limited. In the present study, we established hematologic and biochemical reference intervals for healthy cynomolgus and rhesus monkeys anesthetized with ketamine hydrochloride. A total of 142 cynomolgus monkeys (28 males and 114 females) and 42 rhesus monkeys (22 males and 20 females) were selected and analyzed in order to examine reference intervals of 20 hematological and 16 biochemical parameters. The effects of sex were also investigated. Reference intervals for hematological and biochemical parameters were separately established by species (cynomolgus and rhesus) and sex (male and female). No sex-related differences were determined in erythrocyte-related parameters for cynomolgus and rhesus monkey housed in indoor laboratory conditions. Alkaline phosphatase and gamma glutamyltransferase were significantly lower in females than males in both cynomolgus and rhesus monkeys aged 48-96 months. The reference values for hematological and biochemical parameters established herein might provide valuable information for researchers using cynomolgus and rhesus monkeys in experimental conditions for biomedical studies.

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Section: Discussionmentioning

confidence: 89%

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

et al. 2019

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“…Intra- and inter-study difference in nonhuman primates were known to more variable compare to rodent species. The variables that may account for inter-study variations in cynomolgus monkey include age, sex, geographic origin, presence/absence of anesthetics, fasting, and gravity [ 6 7 8 9 10 11 ]. In addition, analytical instruments, reagents, and methods are variables that could influence the values obtained for a particular parameter, particularly in serum chemistry analysis.…”

Section: Resultsmentioning

confidence: 99%

Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies

et al. 2016

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Nonhuman primates are increasingly used in biomedical research since they are highly homologous to humans compared to other rodent animals. However, there is limited reliable reference data of the clinical pathology parameters in cynomolgus monkeys, and in particular, only some coagulation and urinalysis parameters have been reported. Here, we reported the reference data of clinical chemical, hematological, blood coagulation, and urinalysis parameters in cynomolgus monkeys. The role of sex differences was analyzed and several parameters (including hematocrit, hemoglobin, red blood cell, blood urea nitrogen, total bilirubin, alkaline phosphatase, creatinine kinase, gamma-glutamyl tranferase, and lactate dehydrogenase) significantly differed between male and female subjects. In addition, compared to previous study results, lactate dehydrogenase, creatinine kinase, and aspartate aminotransferase showed significant variation. Interstudy differences could be affected by several factors, including age, sex, geographic origin, presence/absence of anesthetics, fasting state, and the analytical methods used. Therefore, it is important to deliberate with the overall reference indices. In conclusion, the current study provides a comprehensive and updated reference data of the clinical pathology parameters in cynomolgus monkeys and provides improved assessment criteria for evaluating preclinical studies or biomedical research.

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“…However, this should have had little effect on the results obtained. Fasting is not an absolute prerequisite in hematology, and to our knowledge, unless the fasting duration exceeds 16 hours, it has no clinically relevant effects in rats or monkeys .…”

Section: Discussionmentioning

confidence: 96%

Hematologic reference intervals in Cynomolgus (Macaca fascicularis) monkeys

Bourgès‐Abella

Geffré

Moureaux³

et al. 2013

J of Medical Primatology

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Effects of fasting on hematologic and clinical chemical values in cynomolgus monkeys (Macaca fascicularis)

Abstract: These results suggested that clinical pathology data would vary after fasting. The decision to feed or fast before blood collection for clinical pathology tests should be made based on careful consideration.

Cited by 17 publications

References 25 publications

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Reference values of hematological and biochemical parameters in young-adult cynomolgus monkey (Macaca fascicularis) and rhesus monkey (Macaca mulatta) anesthetized with ketamine hydrochloride

Reference values of clinical pathology parameters in cynomolgus monkeys (Macaca fascicularis) used in preclinical studies

Hematologic reference intervals in Cynomolgus (Macaca fascicularis) monkeys

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