Effects of fasting on skeletal muscles and body fat of adult and old C57BL/6J mice

Kvedaras, Mindaugas; Minderis, Petras; Cesanelli, Leonardo; Čekanauskaitė, Agnė; Ratkevičius, Aivaras

doi:10.1016/j.exger.2021.111474

Cited by 2 publications

(1 citation statement)

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“…Extrinsic Zeitgebers like fasting and physical activity alter circadian regulation of skeletal muscle related elements Physical activity or exercise are reported as effective countermeasures against general effects of aging (e.g., sarcopenia) and also play a major role in the prevention of musculoskeletal disorders 81 . Fasting improves metabolic health and is associated with the loss of lean body mass 82 . Yet, it is unclear whether exercise based on time or intensity, or fasting can help reverse the molecular alterations observed due to spaceflight, or aging on Earth.…”

Section: Human Datasetsmentioning

confidence: 99%

Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent

et al. 2023

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The circadian clock regulates cellular and molecular processes in mammals across all tissues including skeletal muscle, one of the largest organs in the human body. Dysregulated circadian rhythms are characteristic of aging and crewed spaceflight, associated with, for example, musculoskeletal atrophy. Molecular insights into spaceflight-related alterations of circadian regulation in skeletal muscle are still missing. Here, we investigated potential functional consequences of clock disruptions on skeletal muscle using published omics datasets obtained from spaceflights and other clock-altering, external (fasting and exercise), or internal (aging) conditions on Earth. Our analysis identified alterations of the clock network and skeletal muscle-associated pathways, as a result of spaceflight duration in mice, which resembles aging-related gene expression changes observed in humans on Earth (e.g., ATF4 downregulation, associated with muscle atrophy). Furthermore, according to our results, external factors such as exercise or fasting lead to molecular changes in the core-clock network, which may compensate for the circadian disruption observed during spaceflights. Thus, maintaining circadian functioning is crucial to ameliorate unphysiological alterations and musculoskeletal atrophy reported among astronauts.

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Section: Human Datasetsmentioning

confidence: 99%