Effects of Fatigue and Long-Term Isolation on Human Behavior

Anikushina, Valentina; Fedyay, S. O.; Kuznetsova, Polina; Vinokhodova, A. G.; Shved, D.М.; Taratukhin, Victor; Stutterheim, Christiane von; Savinkina, Aleksandra; Becker, Jörg; Gushin, Vadim

doi:10.1016/j.trpro.2022.12.007

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Nazemnyy Eksperimental'nyy Kompleks, located in the Institute of Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia, is an isolation facility that accommodates six individuals at a time and is designed to conduct research studies investigating the effects of spaceflight on performance and behavioral health (Anikushina et al., 2022 ; Cromwell et al., 2021 ; Fedyay et al., 2023 ; Le Roy et al., 2023 ). We conducted a 4‐month study ( N = 6 healthy adults; 3 females; mean age ± SD, 34.3 ± 5.7 years; mean body mass index ± SD, 22.5 ± 3.2 kg/m 2 ) from March 2019–July 2019, and a similar 8‐month study ( N = 5 healthy adults; 2 females; mean age ± SD, 33.6 ± 5.17 years; mean body mass index ± SD, 27.1 ± 4.9 kg/m 2 ) from November 2021–July 2022 in the facility (Anikushina et al., 2022 ; Bell et al., 2023 ). Participants had scientific and/or technical backgrounds and human‐support skills relevant for space exploration.…”

Section: Methodsmentioning

confidence: 99%

Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices

Pasetes,

Rosendahl‐Garcia,

Goel

2023

Physiological Reports

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Since short sleep duration adversely affects cardiovascular (CV) health, we investigated the effects of exposures to total sleep deprivation (TSD), and baseline (BL) and recovery (REC) sleep on CV measures. We conducted a 5‐day experiment at months 2 and 4 in two separate studies (N = 11 healthy adults; 5 females). During these repeated experiments, CV measures [stroke volume (SV), cardiac index (CI), systemic vascular resistance index (SVRI), left ventricular ejection time, heart rate (HR), systolic and diastolic blood pressure (SBP and DBP) and mean arterial pressure (MAP)] were collected at three assessment time points after: (1) two BL 8 h time‐in‐bed (TIB) sleep opportunity nights; (2) a TSD night; and (3) two REC 8‐10 h TIB nights. CV measures were also collected pre‐study. TSD significantly increased SV and CI, and decreased SVRI, with large effect sizes, which importantly were reversed with recovery, indicating these measures are possible novel biomarkers for assessing the adverse consequences of TSD. Pre‐study SV, CI, SVRI, HR, SBP, and MAP measures also significantly associated with TSD CV responses at months 2 and 4 [Pearson's r: 0.615–0.862; r2: 0.378–0.743], indicating they are robust correlates of future TSD CV responses. Our novel findings highlight the critical impact of sleep on CV health across time.

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Section: Methodsmentioning

confidence: 99%

Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices

Pasetes,

Rosendahl‐Garcia,

Goel

2023

Physiological Reports

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“…Nazemnyy Eksperimental’nyy Kompleks (NEK), located in the Institute of Biomedical Problems (IBMP) of the Russian Academy of Sciences, Moscow, Russia, is an isolation facility designed to conduct research studies examining the effects of spaceflight on behavioral health and performance ( Cromwell et al, 2021 ; Anikushina et al, 2022 ; Le Roy et al, 2023 ). We conducted a 4-month study ( N = 6 healthy adults; 3 females; mean age ± SD, 34.3 ± 5.7 years; mean BMI ± SD, 22.5 ± 3.2 kg/m 2 ) from March 2019-July 2019, and a similar 8-month study ( N = 5 healthy adults; 2 females; mean age ± SD, 33.6 ± 5.17 years; mean BMI ± SD, 27.1 ± 4.9 kg/m 2 ) from November 2021-July 2022 in the IMBP NEK facility ( Anikushina et al, 2022 ; Bell et al, 2023 ). Participants were not shift workers or exposed to TSD in their professions.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular measures display robust phenotypic stability across long-duration intervals involving repeated sleep deprivation and recovery

2023

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IntroductionWe determined whether cardiovascular (CV) measures show trait-like responses after repeated total sleep deprivation (TSD), baseline (BL) and recovery (REC) exposures in two long-duration studies (total N = 11 adults).MethodsA 5-day experiment was conducted twice at months 2 and 4 in a 4-month study (N = 6 healthy adults; 3 females; mean age ± SD, 34.3 ± 5.7 years; mean BMI ± SD, 22.5 ± 3.2 kg/m2), and three times at months 2, 4, and 8 in an 8-month study (N = 5 healthy adults; 2 females; mean age ± SD, 33.6 ± 5.17 years; mean BMI ± SD, 27.1 ± 4.9 kg/m2). Participants were not shift workers or exposed to TSD in their professions. During each experiment, various seated and standing CV measures were collected via echocardiography [stroke volume (SV), heart rate (HR), cardiac index (CI), left ventricular ejection time (LVET), and systemic vascular resistance index (SVRI)] or blood pressure monitor [systolic blood pressure (SBP)] after (1) two BL 8h time in bed (TIB) nights; (2) an acute TSD night; and (3) two REC 8–10 h TIB nights. Intraclass correlation coefficients (ICCs) assessed CV measure stability during BL, TSD, and REC and for the BL and REC average (BL + REC) across months 2, 4, and 8; Spearman’s rho assessed the relative rank of individuals’ CV responses across measures.ResultsSeated BL (0.693–0.944), TSD (0.643–0.962) and REC (0.735–0.960) CV ICCs showed substantial to almost perfect stability and seated BL + REC CV ICCs (0.552–0.965) showed moderate to almost perfect stability across months 2, 4, and 8. Individuals also exhibited significant, consistent responses within seated CV measures during BL, TSD, and REC. Standing CV measures showed similar ICCs for BL, TSD, and REC and similar response consistency.DiscussionThis is the first demonstration of remarkably robust phenotypic stability of a number of CV measures in healthy adults during repeated TSD, BL and REC exposures across 2, 4, and 8 months, with significant consistency of responses within CV measures. The cardiovascular measures examined in our studies, including SV, HR, CI, LVET, SVRI, and SBP, are useful biomarkers that effectively track physiology consistently across long durations and repeated sleep deprivation and recovery.

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Short‐term and long‐term phenotypic stability of actigraphic sleep metrics involving repeated sleep loss and recovery

Pasetes,

Goel

2024

Journal of Sleep Research

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SummaryFor the first time, we determined whether actigraphic‐assessed sleep measures show inter‐individual differences and intra‐individual stability during baseline (BL) and recovery (REC) phases surrounding repeated total sleep deprivation (TSD). We conducted a 5‐day experiment at Months 2 and 4 in two separate studies (N = 11). During each experiment, sleep measures were collected via wrist actigraphy during two BL 8 h time‐in‐bed (TIB) nights (B1, B2) and during two REC 8–10 h TIB nights (R1, R2). Intraclass correlation coefficients (ICCs) assessed actigraphic measure long‐term stability between 2 and 4 months for (1) the pre‐experimental phase before BL; and (2) the BL (B1 + B2), REC (R1 + R2), and BL and REC average (BL + REC) phases; and short‐term stability at Month 2 and at Month 4; and (3) between B1 versus B2 and R1 versus R2 in each 5‐day experiment. Nearly all ICCs during the pre‐experimental, BL, REC, and BL + REC phases were moderate to almost perfect (0.446–0.970) between Months 2 and 4. B1 versus B2 ICCs were more stable (0.440–0.899) than almost all R1 versus R2 ICCs (−0.696 to 0.588) at Month 2 and 4. Actigraphic sleep measures show phenotypic long‐term stability during BL and REC surrounding repeated TSD between 2 and 4 months. Furthermore, within each 5‐day experiment at Month 2 and 4, the two BL nights before TSD were more stable than the two REC nights following TSD, likely due to increased R1 homeostatic pressure. Given the consistency of actigraphic measures across the short‐term and long‐term, they can serve as biomarkers to predict physiological and neurobehavioral responses to sleep loss.

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Effects of Fatigue and Long-Term Isolation on Human Behavior

Cited by 3 publications

References 12 publications

Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices

Impact of bimonthly repeated total sleep deprivation and recovery sleep on cardiovascular indices

Cardiovascular measures display robust phenotypic stability across long-duration intervals involving repeated sleep deprivation and recovery

Short‐term and long‐term phenotypic stability of actigraphic sleep metrics involving repeated sleep loss and recovery

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