Effects of fatigue on cognitive control in neurosarcoidosis

Beste, Christian; Kneiphof, Janina; Woitalla, Dirk

doi:10.1016/j.euroneuro.2015.01.012

Cited by 14 publications

(16 citation statements)

References 34 publications

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“…Such compensation across these two modes of control could explain why, despite the apparent "disappearance" of conflict adaptation in both FSW and N2 as the task progressed, a behavioral conflict adaptation effect remained intact throughout the task. This kind of compensatory hypothesis was suggested by Boksem et al (2006), who also observed a large reduction in the flanker compatibility effect in the N2 over time-and attributed this effect to fatigue (also see Beste, Kneiphof, & Woitalla, 2015)-but no reduction in the size of the effect in RT. As posited by Boksem and colleagues, "fatigue is more than an effort/reward imbalance and involves adaptive strategies to keep performance at an acceptable level under adverse internal circumstances" (p. 129).…”

Section: Discussionmentioning

confidence: 68%

Temporal dynamics of reactive cognitive control as revealed by event‐related brain potentials

2017

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Reactive cognitive control refers to a complementary set of cognitive operations by which individuals monitor for and detect the presence of goal-interfering conflict (i.e., conflict monitoring/evaluation) and, subsequently, initiate attention-focusing and response selection processes to bolster goal-directed action in the face of such conflict (regulative control). The purpose of the current study was to characterize the nature of conflict adaptation in both components of this dynamic process across sequences of trials and, more broadly, across time as participants complete a cognitive control task. Fifty-two young adults completed a standard arrow flanker task while behavioral and ERP data were recorded. Multilevel modeling of sequences of compatible and incompatible trials over time showed that, whereas response time data demonstrated a typical conflict adaptation effect throughout the task, N2 and frontal slow wave (FSW) indices of conflict monitoring and regulative control, respectively, demonstrated significant conflict adaptation only during the early part of the task. Moreover, although differential change in N2 and FSW over time suggested that conflict monitoring and regulative control were dissociable, a reciprocal relation between them was maintained throughout the task and was not present in a component theoretically unrelated to conflict adaptation (visual attention-related N1). Findings are discussed in terms of compensatory processes that help to maintain goal-directed performance even as control-related neural responses become fatigued.

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Section: Discussionmentioning

confidence: 68%

Temporal dynamics of reactive cognitive control as revealed by event‐related brain potentials

2017

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“…Clinical and laboratory findings can orient toward a specific endocrine and/or metabolic disease rather than CNS sarcoidosis. Furthermore, fatigue can also occur in association with peripheral nervous system disease (35). The clinical picture of CNS sarcoidosis is most often dominated by cranial neuropathy secondary to granulomatous infiltration or to basilar, aseptic meningitis (9), being described in up to 80% of cases (8).…”

Section: Central Nervous System (Cns) Sarcoidosismentioning

confidence: 99%

“…Main findings are central loss or blurred vision, retrobulbar pain, optic nerve atrophy, and papilledema resulting from local granuloma formation (8,37,38). The VII nerve paresis is usually evident unilaterally and less frequently affects both sides of the face (26,35,39). Rarely, the involvement of the VII nerve is associated with other specific symptoms such as Heerfordt's syndrome, a clinical variety characterized by facial nerve palsy, fever, swelling of the parotid glands, and uveitis (40).…”

Section: Central Nervous System (Cns) Sarcoidosismentioning

confidence: 99%

Challenges in the diagnosis and treatment of neurosarcoidosis

et al. 2015

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The diagnosis and treatment of neurosarcoidosis can be very challenging for several reasons. It affects clinically 5%-10% of sarcoidosis patients, but can be found in up to 25% of autopsies. These data reveal that a high percentage of asymptomatic or misdiagnosed cases can be missed at an initial diagnostic approach. Clinical and imaging findings are often non-specific since they can be found in a large number of neurological disorders. Histopathology can also be confounding if not performed by an expert pathologist and not placed in an appropriate clinical context. In this review, we discuss clinical features, laboratory findings, imaging, and histology of neurosarcoidosis, and we report current evidence regarding drug therapy. We conclude that a correct diagnostic approach should include a multidisciplinary evaluation involving clinicians, radiologists, and pathologists and that future studies should evaluate the genetic signature of neurosarcoidosis as they could be helpful in the assessment of this uncommon disease. With head-to-head comparisons of medical treatment for neurosarcoidosis still lacking due to the rarity of the disease and an increasing number of immunomodulating therapies at hand, novel therapeutic approaches are to be expected within the next few years. Key messages Neurosarcoidosis is a rare disorder that affects clinically 5%-10% of sarcoidosis patients, but can be found in up to 25% of autopsies, revealing that a high percentage of asymptomatic or misdiagnosed cases can be missed at an initial diagnostic approach. A multidisciplinary evaluation is useful to achieve a correct diagnosis because clinical and imaging findings are often non-specific. Corticosteroids are the first-line treatment for neurosarcoidosis, followed by steroid-sparing immune-modulating agents if prednisone therapy is insufficient. Dear Author, Please check these proofs carefully. It is the responsibility of the corresponding author to check against the original manuscript and approve or amend these proofs. A second proof is not normally provided. Informa Healthcare cannot be held responsible for uncorrected errors, even if introduced during the composition process. The journal reserves the right to charge for excessive author alterations, or for changes requested after the proofing stage has concluded.The following queries have arisen during the editing of your manuscript and are marked in the margins of the proofs. Unless advised otherwise, submit all corrections using the CATS online correction form. Once you have added all your corrections, please ensure you press the ''Submit All Corrections'' button.Please review the table of contributors below and confirm that the first and last names are structured correctly and that the authors are listed in the correct order of contribution. The diagnosis and treatment of neurosarcoidosis can be very challenging for several reasons. It affects clinically 5%-10% of sarcoidosis patients, but can be found in up to 25% of autopsies. These data reveal that a high percenta...

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“…Incidence varies in different countries from 4 to 47 casesper 100,000 people [3][4][5][6][7][8]. The research surveys show a positive dynamics of neurosarcoidosis incidence [1].…”

Section: Introductionmentioning

confidence: 99%

“…The research surveys show a positive dynamics of neurosarcoidosis incidence [1]. Neurosarcoidosis distributes among people of all age groupsbut people at the age of 34-40 are mostly prone to the disease [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological diagnostics of neurosarcoidosis

Vera¹,

Yuliya²,

Sergey³

et al. 2018

Russ Open Med J

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This article presents the results of neuropsychological studies of the patients with neurosarcoidosis. The obtained results show that typical manifestations of neurosarcoidosis are disorders of motor functions. They appear in the speed reduction of actions and their accuracy, which prove peripheral neuropathy and myopathy at the functional level as clinical signs of neurosarcoidosis. Specific manifestations of neurosarcoidosisare determinedby topographical localization of granulomatoma.

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Effects of fatigue on cognitive control in neurosarcoidosis

Cited by 14 publications

References 34 publications

Temporal dynamics of reactive cognitive control as revealed by event‐related brain potentials

Temporal dynamics of reactive cognitive control as revealed by event‐related brain potentials

Challenges in the diagnosis and treatment of neurosarcoidosis

Neuropsychological diagnostics of neurosarcoidosis

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