Effects of fatty acid metabolites on nocturia

Ihara, Takeshi; Shimura, Hiroshi; Tsuchiya, Satoshi; Kanda, Mie; Kira, Satoru; Sawada, Norifumi; Takeda, Masayuki; Mitsui, Takahiko; Shigetomi, Eiji; Shinozaki, Yukiko; Koizumi, Schuichi

doi:10.1038/s41598-022-07096-5

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…Increased fatty acid metabolites were also identified in the results of studies that looked for serum metabolomic biomarkers of nocturia [23,25]. This discovery led to preclinical research evaluating the circadian rhythm of fatty acid metabolism and their effect on voiding in mice [49], which showed that increased serum levels of fatty acid metabolites during sleep from circadian rhythm disturbances can cause nocturia and that fatty acid metabolic pathways were involved in the regulation of clock genes. Based on circadian rhythm disorders and recent findings on chronotherapy [50], these results may have two future dimensions, the first pathophysiological hypothesis of the involvement of fatty acid metabolites in nocturia and the second clinical with a possibility of monitoring circadian rhythm via metabolomic markers of fatty acids in serum.…”

Section: Discussionmentioning

confidence: 99%

‘Nocturomics’: transition to omics‐driven biomarkers of nocturia, a systematic review and future prospects

et al. 2023

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Objective To systematically review studies that investigated different biomarkers of nocturia, including omics‐driven biomarkers or ‘Nocturomics’. Materials and Methods PubMed®, Scopus®, and Embase® were searched systematically in May 2022 for research papers on biomarkers in physiological fluids and tissues from patients with nocturia. A distinction was made between biomarkers or candidates discovered by omics techniques, referred to as omics‐driven biomarkers, and classical biomarkers, measured by standard laboratory techniques and mostly thought from pathophysiological hypothesis. Results A total of 13 studies with 18 881 patients in total were included, eight of which focused on classical biomarkers including: atrial natriuretic peptide (ANP), B‐type natriuretic peptide (BNP), C‐reactive protein (CRP), aldosterone, and melatonin. Five were ‘Nocturomics’, including one that assessed the microbiome and identified 27 faecal and eight urinary bacteria correlated with nocturia; and four studies that identified candidate metabolomic biomarkers, including fatty acid metabolites, serotonin, glycerol, lauric acid, thiaproline, and imidazolelactic acid among others. To date, no biomarker is recommended in clinical practice. Nocturomics are in an embryonic phase of conception but are developing quickly. Although candidate biomarkers are being identified, none of them are yet validated on a large sample, although some preclinical studies have shown a probable role of fatty acid metabolites as a possible biomarker of circadian rhythm and chronotherapy. Conclusion Further research is needed to validate biomarkers for nocturia within the framework of a diagnostic and therapeutic precision medicine perspective. We hope this study provides a summary of the current biomarker discoveries associated with nocturia and details future prospects for omics‐driven biomarkers.

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Section: Discussionmentioning

confidence: 99%

‘Nocturomics’: transition to omics‐driven biomarkers of nocturia, a systematic review and future prospects

et al. 2023

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“…The interaction between ω-3 fatty acids and the molecular clock should not only be understood as exerted by the former on the latter but as a bidirectional relationship. In murine models, urinary levels of fatty acid metabolites, such as 4-hydroxy-5E, 7Z, 10Z, 13Z, 16Z, and 19Z-docosahexaenoic acid (4-HDoHE), were higher in CLOCK mutant compared with wild-type mice [ 160 ]. From a neurological point of view, RORα deficiency was associated with alterations in fatty acid accretions in the cerebellum and secondary neurological impairments [ 161 ].…”

Section: Discussionmentioning

confidence: 99%

Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers

Checa-Ros

D’Marco

2022

IJMS

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Omega-3 fatty acids (ω-3 FAs) are well-known for their actions on immune/inflammatory and neurological pathways, functions that are also under circadian clock regulation. The daily photoperiod represents the primary circadian synchronizer (‘zeitgeber’), although diverse studies have pointed towards an influence of dietary FAs on the biological clock. A comprehensive literature review was conducted following predefined selection criteria with the aim of updating the evidence on the molecular mechanisms behind circadian rhythm regulation by ω-3 FAs. We collected preclinical and clinical studies, systematic reviews, and metanalyses focused on the effect of ω-3 FAs on circadian rhythms. Twenty animal (conducted on rodents and piglets) and human trials and one observational study providing evidence on the regulation of neurological, inflammatory/immune, metabolic, reproductive, cardiovascular, and biochemical processes by ω-3 FAs via clock genes were discussed. The evidence suggests that ω-3 FAs may serve as non-photic zeitgebers and prove therapeutically beneficial for circadian disruption-related pathologies. Future work should focus on the role of clock genes as a target for the therapeutic use of ω-3 FAs in inflammatory and neurological disorders, as well as on the bidirectional association between the molecular clock and ω-3 FAs.

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“…Only 0.4% of adults under the age of 40 have nocturia, compared to 11.5% of those over the age of 60 [29]. Additionally, men with normotension were 39% less likely than untreated hypertensive patients to report nocturia [30].Therefore, risk factors for nocturia include aging, hypertension, diabetes, and obesity [27,28,31,32], which all contribute to chronic renal disease [33][34][35][36]. However, we conducted an interaction study of variables with nocturia to validate their impact on the result, and it revealed that hypertension alone substantially impacted the association between nocturia and eGFR.…”

Section: Discussionmentioning

confidence: 99%

Association of nocturia with estimated glomerular filtration rate: a cross-sectional study from the NHANES 2005-2018

Song

Fang

2022

Preprint

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Background Nocturia is a manifestation of systemic disease, of which chronic kidney disease is an independent predictor of nocturia because of its osmotic diuretic mechanism. However, to our knowledge, previous studies have not examined the relationship between nocturia and eGFR. Objective The purpose of this study was to assess the association between nocturia exposure and eGFR in the general US population. Methods Our study was a cross-sectional examination of 12,265 regular Americans who took part in the rvey NHANES between 2005 and 2018. After controlling for gender, age, race, fasting blood glucose, glycosylated hemoglobin, ALT, AST, TG, CHOL, HDL, LDL, BMI, diabetes, hypertension, alcohol consumption, tobacco use and PHQ9 score, a multiple regression analysis was performed to determine the association between nocturia and eGFR. Covariate-specific hierarchical analysis and interaction testing were performed. A sensitivity analysis was then conducted between the CKD group, the non-CKD group, and the various CKD prognostic risk groups. Results Multiple regression analysis showed that the frequency of nocturia increased by 1 time, and eGFR decreased 2.0 mL/min/1.73m2 (95%CI: -2.4, -1.7). Compared with no nocturia, the decrease of eGFR was the most significant 4 times per night (95%CI: -10.7, -5.4). Our results remained stable in the CKD and non-CKD groups. Within all CKD prognostic risk groups, only the moderately increased risk and low-risk groups had comparable results. Conclusions Increased frequency of nocturia was associated with a decrease in eGFR, regardless of the diagnosis of CKD. However, no correlation between nocturia and eGFR was observed in very high risk and high risk groups.

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Effects of fatty acid metabolites on nocturia

Cited by 7 publications

References 36 publications

‘Nocturomics’: transition to omics‐driven biomarkers of nocturia, a systematic review and future prospects

‘Nocturomics’: transition to omics‐driven biomarkers of nocturia, a systematic review and future prospects

Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers

Association of nocturia with estimated glomerular filtration rate: a cross-sectional study from the NHANES 2005-2018

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