2006
DOI: 10.1097/00029330-200610020-00006
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Effects of fatty acid regulation on visfatin gene expression in adipocytes

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Cited by 27 publications
(20 citation statements)
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“…In contrast with the n−3 PUFA EPA, the saturated NEFA palmitate and mono-unstaturated NEFA oleate down-regulated visfatin mRNA gene expression in 3T3-L1 adipocytes and pre-adipocytes [18]. Moreover, this down-regulation of visfatin was suggested as a potential mechanism to directly induce insulin resistance by oleate and palmitate in vitro [18]. In this context, it has also been shown that a synthetic mixture including stearate, oleate, linoleate, linolenate and arachidonate normalized the increase in visfatin release induced by treatment with the insulinsensitizing PPAR-γ (peroxisome-proliferator-activated receptor-γ ) agonist rosiglitazone in human isolated adipocytes [32].…”
Section: Discussionmentioning
confidence: 80%
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“…In contrast with the n−3 PUFA EPA, the saturated NEFA palmitate and mono-unstaturated NEFA oleate down-regulated visfatin mRNA gene expression in 3T3-L1 adipocytes and pre-adipocytes [18]. Moreover, this down-regulation of visfatin was suggested as a potential mechanism to directly induce insulin resistance by oleate and palmitate in vitro [18]. In this context, it has also been shown that a synthetic mixture including stearate, oleate, linoleate, linolenate and arachidonate normalized the increase in visfatin release induced by treatment with the insulinsensitizing PPAR-γ (peroxisome-proliferator-activated receptor-γ ) agonist rosiglitazone in human isolated adipocytes [32].…”
Section: Discussionmentioning
confidence: 80%
“…In contrast with the n−3 PUFA EPA, the saturated NEFA palmitate and mono-unstaturated NEFA oleate down-regulated visfatin mRNA gene expression in 3T3-L1 adipocytes and pre-adipocytes [18]. Moreover, this down-regulation of visfatin was suggested as a potential mechanism to directly induce insulin resistance by oleate and palmitate in vitro [18].…”
Section: Discussionmentioning
confidence: 97%
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“…Polyunsaturated fatty acids stimulated AMP-activated protein kinase and increased visfatin secretion in cultured murine adipocytes [28]. In another in vitro study [29], dose-response studies demonstrated that addition of oleate and palmitate to 3T3-L1 adipocytes decreased visfatin mRNA expression. Hence, we hypothesized that the dietary intakes of pregnants may explain the variability of findings in previous studies.…”
Section: Discussionmentioning
confidence: 93%
“…Ces résultats, variables selon le type d'acides gras, pourraient expliquer en partie les résultats contradictoires obtenus in vivo quant à la régulation de la résistine. Enfin, sous l'effet d'acides gras (acide oléique et acide palmitique), la transcription de la visfatine est inhibée dans la lignée cellulaire 3T3-L1 [31].…”
Section: Acides Gras Libresunclassified