Effects of fatty infiltration of the graft on the outcome of living-related liver transplantation

Hayashi, Michihiro; Fujii, Kazumichi; Kiuchi, Tetsuya; Uryuhara, Kenji; Kasahara, Mureo; Takatsuki, Mitsuhisa; Takeichi, Takayuki; Kitade, Hiroaki; Sugimoto, Takeyuki; Üemoto, Shinji; Asonuma, Katsuhiro; Egawa, Hiroto; Fujita, Sg.; Inomata, Yukihiro; Tanaka, Kōichi

doi:10.1016/s0041-1345(98)01679-0

Cited by 85 publications

(57 citation statements)

References 1 publication

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“…(32) Grafts with moderate steatosis (30-59%) can be used, provided they are well allocated to recipients (i.e., recipients free from other risk factors). (34,35) Transplantation of grafts with severe (over 60%) steatosis is limited to a few centers; most groups choose not to use such grafts out of increased EAD and PNF risk concerns. (35,36) Given the limited availability of grafts compared to organ demands, several transplant centers use marginal donors.…”

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 99%

“…(34,35) Transplantation of grafts with severe (over 60%) steatosis is limited to a few centers; most groups choose not to use such grafts out of increased EAD and PNF risk concerns. (35,36) Given the limited availability of grafts compared to organ demands, several transplant centers use marginal donors. Such donors are defined as expanded criteria donors according to the following: age ≥60 years, body mass index >27 to 30kg/m 2 , macrovesicular steatosis ≥30%, length of stay at ICU >4 to 5 days, use of vasoactive drugs (dopamine at doses >10μ/kg/minute or any other catecholamine, regardless of dosage), longstanding hypotension (over 1 hour), serum sodium levels >150-155mmol/L, cold ischemia time >8 hours, hot ischemia time >40-45 minutes, controlled sepsis, serum creatinine levels >1.2mg/dL, history of alcoholism, serum bilirubin, ALT and AST levels >2.0mg/dL, >170IU/L and >140IU/L, respectively.…”

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 99%

“…Steatosis macro ≥30% (34)(35)(36) Hot ischemia time >40 minutes (39) >45 minutes (44) Young recipients (tend to receive organs from expanded criteria donors) (5,8,39,43) Expanded criteria donors (1,4,7) Cold ischemia time >10 hours (8,43) Age >49 years (8,43) >65 years (30) …”

Section: Surgical Procedures Recipientmentioning

confidence: 99%

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Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Neves

Rusi

Díaz

et al. 2016

Einstein (São Paulo)

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Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: "primary graft dysfunction", "early allograft dysfunction", "primary non-function" and "liver transplantation". Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery-and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies.

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Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 99%

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 99%

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Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Neves

Rusi

Díaz

et al. 2016

Einstein (São Paulo)

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“…25 In animal models, the low-choline methionine diet produces periportal infiltration, whereas the cholesterol model used by Seifalian et al 26 induces central lobular change. 27,28 These regional differences may reflect zonal biochemical variations within liver sinusoids.…”

Section: Experimental Models Of Fatty Livermentioning

confidence: 99%

Hepatic steatosis and its relationship to transplantation

Imber

Peter

Handa

et al. 2002

Liver Transplantation

150

108

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“…31 In another analysis of grafts from living donors with varying degrees of steatosis, only severe steatosis greater than 60% was associated with poor graft function and outcome. 69 Mild to moderate steatosis does not mandate donor exclusion, but significant steatosis may represent undis- …”

Section: Steatosis In Graftsmentioning

confidence: 99%

Right lobe living donor liver transplantation: A review

Marcos

2000

Liver Transpl

159

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The continuing shortage of organs for adult transplant recipients has generated enthusiasm for adult-to-adult living donor liver transplantation (LDLT). The major concern has been the ability to resect a graft of adequate size without subjecting the donor to undue risk. The right hepatic lobe is generally large enough for adult recipients, but because of the real and perceived risks of right lobe (RL) resection, surgeons have been hesitant to offer this option to their patients. The first series of RL resections that included a significant number of patients was reported in 1999, and the results were encouraging. Only minor complications occurred in donors, and the recipients fared quite well. Enthusiasm for these donor resections is growing, and more centers are beginning to perform them. There is a good deal of global experience with pediatric LDLT but little with adults, and there are unique considerations in this population. This review examines donor selection criteria for adult recipients, highlights technical points critical for good outcome, and examines the early results and complications in both donors and recipients. If the preliminary results continue to be reproduced, RL LDLT could have significant impact on the worsening organ shortage.

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Effects of fatty infiltration of the graft on the outcome of living-related liver transplantation

Cited by 85 publications

References 1 publication

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Hepatic steatosis and its relationship to transplantation

Right lobe living donor liver transplantation: A review

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