Effects of Fatty Liver Induced by Niacin-free Diet with Orotic Acid on the Metabolism of Tryptophan to Niacin in Rats

Fukuwatari, Tsutomu; Morikawa, Yuko; Sugimoto, Etsuro; Shibata, Katsumi

doi:10.1271/bbb.66.1196

Cited by 23 publications

(18 citation statements)

References 46 publications

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“…Other studies have reported that orotic acid administration produces alterations on metabolism of tryptophan to niacin (Fukuwatari et al, 2002) and improves cardiac function (Ferdinandy et al, 1998).…”

Section: Introductionmentioning

confidence: 98%

Fenofibrate prevents orotic acid—Induced hepatic steatosis in rats

Ferreira¹,

Parreira²,

Porto³

et al. 2008

Life Sciences

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Section: Introductionmentioning

confidence: 98%

Fenofibrate prevents orotic acid—Induced hepatic steatosis in rats

Ferreira¹,

Parreira²,

Porto³

et al. 2008

Life Sciences

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“…In the fatty liver, TDO activity was decreased to 40%, the conversion ratio of tryptophan to nicotinamide to 30%, and liver NAD levels to 60% of the values in control animals. Chronic renal failure was induced by feeding an adenine-containing diet 13. Renal failure led to decreases in liver TDO, liver QPRT, and kidney ACMSD activities, and to an increase in liver ACMSD activity, causing the liver enzymes to suppress the conversion of nicotinamide to tryptophan and the kidney enzymes to enhance it.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Aspect of Tryptophan Metabolism

Fukuwatari

Shibata

2013

Int J�Tryptophan�Res

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Mammals, including humans, can synthesize the vitamin nicotinamide from tryptophan in the liver. The resultant nicotinamide is distributed to non-hepatic tissues. We have studied the effects of changes in tryptophan–nicotinamide metabolism on niacin nutritional status. The liver plays a critical role in nicotinamide supply. Animal studies showed that the tryptophan–nicotinamide pathway is affected by physiological conditions, the presence of disease, nutrients, hormones, and chemicals. Human studies have shown that 1 mg of nicotinamide is produced from 67 mg of tryptophan intake, and that the conversion ratio of tryptophan to nicotinamide is enhanced from mid to late pregnancy. These findings have contributed to the determination of dietary reference intakes for niacin recommended in the Dietary Reference Intakes for Japanese 2010. Our findings suggest that the conversion of nicotinamide from tryptophan is important in maintaining niacin nutrition.

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“…1). Numerous factors such as pregnancy, 7) nutrition, [8][9][10][11][12][13][14][15] hormones, [16][17][18][19][20] chemicals, [21][22][23][24][25][26] and experimental models of diseases [27][28][29] affect this conversion from tryptophan to nicotinamide. However, little is known about the association between the nicotinamide intake and tryptophan-nicotinamide pathway.…”

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confidence: 99%