Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Farooq, Muhammad; Ali, Sultan; Jamil, Huma; Ahmad, Nazir; Ashfaq, Khurram

doi:10.1530/endoabs.50.p365

Cited by 4 publications

(12 citation statements)

References 14 publications

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“…The included studies were published between 2002 and 2019. All studies were conducted using animal models: rats [ 67 , 69 , 74 , 75 ], lambs [ 71 ], calves [ 72 ], goats [ 70 ], and chicken [ 68 , 73 ]. No in vitro or human studies on this topic have been conducted.…”

Section: Resultsmentioning

confidence: 99%

“…No in vitro or human studies on this topic have been conducted. Four studies employed olive leaf extract [ 67 , 68 , 73 , 74 ], while another three studies used olive oil [ 69 , 70 , 75 ]. Abd-Alla et al [ 71 ] and Abdalla et al [ 72 ] used solid olive pulp and solid pomace, respectively, which are residues from olive oil extraction or olive fruit squeezing.…”

Section: Resultsmentioning

confidence: 99%

“…Abd-Alla et al [ 71 ] and Abdalla et al [ 72 ] used solid olive pulp and solid pomace, respectively, which are residues from olive oil extraction or olive fruit squeezing. All included studies administrated the olive derivatives orally, i.e., through the diet, by oral gavage [ 68 , 69 , 70 , 71 , 72 , 75 ], or in drinking water [ 73 , 74 ]. Al-Qarawi et al [ 67 ] did not disclose the details of oral administration, but it is assumed that oral gavage was used.…”

Section: Resultsmentioning

confidence: 99%

“…EVOO was used at a concentration of 0.5 g/kg body weight (approximately 137.5 mg for each 275 g rat) for 21 days [ 69 ] or 0.6 g/kg body weight daily (approximately 90–120 mg for each 150–200 g rat) for 28 days [ 75 ]. Farooq et al [ 70 ] supplemented goats with 15 or 30 mL of commercially available olive oil (unknown specification) for 8 weeks. Olive leaf extracts in the lyophilized form were given to rats at a dose of 100–500 µg/day for 2 weeks [ 67 ].…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, 300 g of solid olive pulp was added to a basal diet and given to lambs for 3 months [ 71 ], and 15% solid olive pomace was added to a calf diet for 2 months [ 72 ]. The thyroid profile, including T3, T4, and/or TSH, was determined in healthy euthyroid animals [ 67 , 68 , 69 , 70 ] or animals under heat stress- [ 71 , 72 , 73 ] or with chemically-induced hypothyroidism [ 74 , 75 ]. TRH was not determined in any of the included studies.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review

2021

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Olive oil, which is commonly used in the Mediterranean diet, is known for its health benefits related to the reduction of the risks of cancer, coronary heart disease, hypertension, and neurodegenerative disease. These unique properties are attributed to the phytochemicals with potent antioxidant activities in olive oil. Olive leaf also harbours similar bioactive compounds. Several studies have reported the effects of olive phenolics, olive oil, and leaf extract in the modulation of thyroid activities. A systematic review of the literature was conducted to identify relevant studies on the effects of olive derivatives on thyroid function. A comprehensive search was conducted in October 2020 using the PubMed, Scopus, and Web of Science databases. Cellular, animal, and human studies reporting the effects of olive derivatives, including olive phenolics, olive oil, and leaf extracts on thyroid function were considered. The literature search found 445 articles on this topic, but only nine articles were included based on the inclusion and exclusion criteria. All included articles were animal studies involving the administration of olive oil, olive leaf extract, or olive pomace residues orally. These olive derivatives were consistently demonstrated to have thyroid-stimulating activities in euthyroid or hypothyroid animals, but their mechanisms of action are unknown. Despite the positive results, validation of the beneficial health effects of olive derivatives in the human population is lacking. In conclusion, olive derivatives, especially olive oil and leaf extract, could stimulate thyroid function. Olive pomace residue is not suitable for pharmaceutical or health supplementation purposes. Therapeutic applications of olive oil and leaf extract, especially in individuals with hypothyroidism, require further validation through human studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review

2021

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Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Centrone

Ranieri

Mise

et al. 2021

FFHD

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In the last few years, the production of olive oil has incredibly increased due to its beneficial properties on human health. On the other hand, the amount of waste and by-products derived from the olive oil industry has increased as well, prompting the development of new fields of research aiming to reduce disposal costs and valorize bioactive compounds from the viewpoint of the green economy. Interestingly, olive oil and by-products contain numerous molecules, including phenols, exhibiting pleiotropic effects in both in vitro and in vivo studies. This review aims to describe the more recent studies focusing to identify and describe the potential roles and the new applications of extracts isolated from wastes and by-products or specific compounds, such as hydroxytyrosol (HT) and oleuropein. Extracts or bioactive molecules from olive oil and by-products have been proposed as a food additive, to produce biofuel, for animal feeding, and to create new matrices in bioremediation protocols. Moreover, bio-compounds have been described to have numerous beneficial effects on human health as they reduce the risk of developing certain chronic diseases. Despite the already published studies, more research is necessary to valorize bioactive compounds in olive oil and by-products, as well as their potential use to improve human health and green applications in different industrial processes. Keywords: extra virgin olive oil, by-products, olive leaf extract, bioactive compounds, human health, and industrial application

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Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Leko

Gunjača

Pleić

et al. 2021

IJMS

131

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Thyroid hormones are necessary for the normal functioning of physiological systems. Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters the levels of thyroid-stimulating hormone (TSH) and thyroid hormones is crucial. Genetic factors contribute up to 65% of interindividual variations in TSH and thyroid hormone levels, but many environmental factors can also affect thyroid function. This review discusses studies that have analyzed the impact of environmental factors on TSH and thyroid hormone levels in healthy adults. We included lifestyle factors (smoking, alcohol consumption, diet and exercise) and pollutants (chemicals and heavy metals). Many inconsistencies in the results have been observed between studies, making it difficult to draw a general conclusion about how a particular environmental factor influences TSH and thyroid hormone levels. However, lifestyle factors that showed the clearest association with TSH and thyroid hormones were smoking, body mass index (BMI) and iodine (micronutrient taken from the diet). Smoking mainly led to a decrease in TSH levels and an increase in triiodothyronine (T3) and thyroxine (T4) levels, while BMI levels were positively correlated with TSH and free T3 levels. Excess iodine led to an increase in TSH levels and a decrease in thyroid hormone levels. Among the pollutants analyzed, most studies observed a decrease in thyroid hormone levels after exposure to perchlorate. Future studies should continue to analyze the impact of environmental factors on thyroid function as they could contribute to understanding the complex background of gene–environment interactions underlying the pathology of thyroid diseases.

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Effects of feed supplementation with olive oil on serum testosterone, triiodothyronine, thyroxine and some biochemical metabolites in Teddy goat bucks

Cited by 4 publications

References 14 publications

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review

Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review

Health benefits of olive oil and by-products and possible innovative applications for industrial processes

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

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