Effects of feeding Bt MON810 maize to sows during first gestation and lactation on maternal and offspring health indicators

Walsh, M. C.; Buzoianu, Stefan G.; Gardiner, Gillian E.; Rea, Mary C.; O'Donovan, Orla; Ross, R. Paul; Lawlor, Peadar G.

doi:10.1017/s0007114512002607

Cited by 14 publications

(17 citation statements)

References 25 publications

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“…According to Winnicka (29), average values of estimated blood indices are located in the range typical for healthy adult swine. These results remain in agreement with findings of Walsh's et al (27), who showed that feed mixture containing MON810 maize did not influence the biochemistry and haematological indices in sows and their offspring. Another experiment by Walsh et al (28), carried out on weaned piglets receiving GM maize for 80 or 110 d, did not confirm any effect of the diet on basic haematological indices (erythrocyte count, erythrocyte parameters, haemoglobin concentration, and haematocrit).…”

Section: Discussionsupporting

confidence: 93%

“…Piglets rearing indices also remained unchanged. The studies conducted by Walsh et al (27) on sows receiving mixtures with GM or not-GM maize showed a similar body weight at the beginning and at the end of pregnancy, as well as a similar backfat thickness for both treatments. Moreover, the average daily body weight gains of their nursing progeny were not affected by maternal feeding.…”

Section: Discussionmentioning

confidence: 86%

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Effect of feeding genetically modified maize and soybean meal to sows on their reproductive traits, haematological indices and offspring performance

Świątkiewicz

Bednarek

Markowski

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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The effect of Roundup Ready MON-40-3-2 soybean meal and Bt maize MON810 on sows performance and haematological indices, including parameters of erythrocytes, leukocytes, and trombocytes, as well as the piglets rearing indices were evaluated in the experiment carried out on 24 sows and their progeny. After mating sows were divided into groups: I -control, conventional soybean meal and conventional maize; II -genetically modified (GM) soybean meal and conventional maize; IIIconventional soybean meal and GM maize; IV -GM soybean meal and GM maize. All used feed mixtures were isonitrogenous and isoenergetic, however differed in presence or absence of genetically modified maize MON810 (5% for pregnant and 8% for lactating sows) and/or soybean meal MON-40-3-2 (4% for pregnant and 14% for lactating sows). Born piglets were allotted to the same group as their mothers. The study showed that feeding pregnant and lactating sows with mixtures containing genetically modified RR soybean or/and meal Bt maize did not significantly affect their reproductive characteristics and offspring performance. There was no effect of dietary treatment on haematological indices. Transfer of transgenic DNA from GM feed to blood was not confirmed.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 86%

Effect of feeding genetically modified maize and soybean meal to sows on their reproductive traits, haematological indices and offspring performance

Świątkiewicz

Bednarek

Markowski

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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“…Significantly higher plasma activities of ALT were seen in female rats fed GM (GNA) rice . Minimal effects were also reported (Walsh et al, 2013) where ALT and AST were also slightly increased in sows fed on GM maize during gestation. ALT and AST activity was slightly altered in mice fed on GM soybean compared to a non-GM diet (Malatesta et al, 2002).…”

Section: Discussionmentioning

confidence: 82%

Biological impact of feeding rats with a genetically modified-based diet

Oraby¹,

Kandil²,

Shaffie³

et al. 2015

Turk J Biol

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This work was conducted in the context of postmarketing biosafety assessment of genetically modified products. It presents a systematic approach based on a chronic toxicity study on Wistar albino rats, with a range of combined parameters including biochemical, histopathological, and cytogenetic to evaluate the negative impact of a genetically modified (GM) diet on animal health. Histopathological and biochemical analysis procedures were performed in the liver, kidney, and testis. Cytogenetic analysis was evaluated in germ cells and the liver. The results revealed that the laboratory diet used in our investigation was proved experimentally, using the PCR assay, to contain genetically modified components without being labeled as such. The results of all parameters evaluated in our investigation were consistent and confirm that the GM diet fed to rats for 30, 60, or 90 days has deleterious histopathological and histochemical impacts. Biochemical alterations in alanine aminotransferase, aspartate aminotransferase, creatinine, uric acid, and malondialdehyde concentrations were also observed. Genotoxicity of the GM diet was also demonstrated in germ cells as increased numbers of cells with chromosomal aberrations and in liver cells as increased ratios of DNA fragmentation. In conclusion, the results of the present work indicate that there are health hazards linked to the ingestion of diets containing genetically modified components.

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“…Although no difference was observed in fecal Lactobacillus counts using traditional culturing methods, this can be attributed to the inability of culture-based approaches to account for unculturable lactobacilli (40). Lower intestinal Lactobacillus counts would generally be perceived as negative as this genus is considered to have a beneficial role in the porcine, as well as the human, intestine (41,42); however, no health abnormalities were observed in the sows (21,34).…”

Section: Discussionmentioning

confidence: 99%

“…All diets were formulated to meet or exceed the National Research Council requirements for pigs at each production stage (23). Details of animal feeding have previously been described by Walsh et al (21) and Buzoianu et al (22).…”

Section: Pig Feeding Studymentioning

confidence: 99%

Sequence-Based Analysis of the Intestinal Microbiota of Sows and Their Offspring Fed Genetically Modified Maize Expressing a Truncated Form of Bacillus thuringiensis Cry1Ab Protein (Bt Maize)

Buzoianu

Walsh

Rea

et al. 2013

Appl Environ Microbiol

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eThe aim was to investigate transgenerational effects of feeding genetically modified (GM) maize expressing a truncated form of Bacillus thuringiensis Cry1Ab protein (Bt maize) to sows and their offspring on maternal and offspring intestinal microbiota. Sows were assigned to either non-GM or GM maize dietary treatments during gestation and lactation. At weaning, offspring were assigned within sow treatment to non-GM or GM maize diets for 115 days, as follows: (i) non-GM maize-fed sow/non-GM maize-fed offspring (non-GM/non-GM), (ii) non-GM maize-fed sow/GM maize-fed offspring (non-GM/GM), (iii) GM maize-fed sow/non-GM maize-fed offspring (GM/non-GM), and (iv) GM maize-fed sow/GM maize-fed offspring (GM/GM). Offspring of GM maize-fed sows had higher counts of fecal total anaerobes and Enterobacteriaceae at days 70 and 100 postweaning, respectively. At day 115 postweaning, GM/non-GM offspring had lower ileal Enterobacteriaceae counts than non-GM/non-GM or GM/GM offspring and lower ileal total anaerobes than pigs on the other treatments. GM maize-fed offspring also had higher ileal total anaerobe counts than non-GM maize-fed offspring, and cecal total anaerobes were lower in non-GM/GM and GM/ non-GM offspring than in those from the non-GM/non-GM treatment. The only differences observed for major bacterial phyla using 16S rRNA gene sequencing were that fecal Proteobacteria were less abundant in GM maize-fed sows prior to farrowing and in offspring at weaning, with fecal Firmicutes more abundant in offspring. While other differences occurred, they were not observed consistently in offspring, were mostly encountered for low-abundance, low-frequency bacterial taxa, and were not associated with pathology. Therefore, their biological relevance is questionable. This confirms the lack of adverse effects of GM maize on the intestinal microbiota of pigs, even following transgenerational consumption.

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Effects of feeding Bt MON810 maize to sows during first gestation and lactation on maternal and offspring health indicators

Cited by 14 publications

References 25 publications

Effect of feeding genetically modified maize and soybean meal to sows on their reproductive traits, haematological indices and offspring performance

Effect of feeding genetically modified maize and soybean meal to sows on their reproductive traits, haematological indices and offspring performance

Biological impact of feeding rats with a genetically modified-based diet

Sequence-Based Analysis of the Intestinal Microbiota of Sows and Their Offspring Fed Genetically Modified Maize Expressing a Truncated Form of Bacillus thuringiensis Cry1Ab Protein (Bt Maize)

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