Effects of Feeding Different Fats on Serum-Cholesterol Level

Bronte‐Stewart, B.; Antonis, A.; Eales, L; Brock, J. F.

doi:10.1016/s0140-6736(56)90592-x

Cited by 380 publications

(50 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A high intake of saturated fatty acids (SFA) can result in elevated plasma cholesterol, which contributes to cardiovascular disease (Bronte-Stewart et al, 1956). SFA are the main fatty acids found in meat, and approximately 80% of the fatty acid in beef is composed of palmitic (C16:0), stearic (C18:0), and oleic acid (C18:1), while the remaining 20% is distributed among 30 different fatty acids (Whetsell et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls

Liu¹,

Zhang²,

Yuan³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The sterol regulatory element binding factor 1 gene (SREBP1) plays an important role in the biosynthesis of fatty acids and cholesterol, and in lipid metabolism. The objective of this study was to investigate the effect of genetic polymorphisms of SREBP1 on the fatty acid composition of muscle and carcass traits in Simmental bulls and Snow Dragon black cattle. The 84-bp insertion/deletion (indel) in intron 5 of the bovine SREBP1 gene was genotyped by polymerase chain reaction to investigate its associations with traits. The results showed that the 84-bp indel in intron 5 was significantly associated with palmitoleic acid (C16:1), stearic acid (C18:0), saturated fatty acids (SFA), triglycerides (TAG), and the C16 index in Simmental bulls (P < 0.05). Cattle with the LL genotype had higher palmitic acid (C16:1), triglycerides, and C16 index but lower stearic acid (C18:0) and SFA compared to those with the LS genotype (P < 0.05). In conclusion, the 84-bp indel of SREBP1 could be used as a genetic marker for selecting Simmental breeding stock for healthier fatty acid composition.

show abstract

Section: Introductionmentioning

confidence: 99%

Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls

Liu¹,

Zhang²,

Yuan³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…High intake of SFA causes elevated plasma cholesterol, which contributes to cardiovascular disease (Bronte-Stewart et al, 1956). In contrast, PUFA and MUFA increase hepatic low-density lipoprotein receptor activity, thereby decreasing the circulating concentration of LDL-cholesterol (Woollett et al, 1992;Rudel et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Effects of breed, sex, and halothane genotype on fatty acid composition of pork longissimus muscle1

Zhang

Knight

Stalder

et al. 2007

Journal of Animal Science

View full text Add to dashboard Cite

The objective of this study was to estimate the effects of breed, sex, and halothane genotype on fatty acid composition and several fatty acid indices of lipid extracted from porcine LM. Purebred Yorkshire (n = 436), Duroc (n = 353), Hampshire (n = 218), Spotted (n = 187), Chester White (n = 173), Poland China (n = 124), Berkshire (n = 256), and Landrace (n = 187) pigs (n = 1,934; 1,128 barrows and 806 gilts) from 1991, 1992, 1994, and 2001 National Barrow Show Sire Progeny Tests were used. Pigs were classified as the HAL-1843 normal (NN) genotype (n = 1,718) or the HAL-1843 carrier (Nn) genotype (n = 216). For statistical analysis, a mixed model was used that included fixed effects of breed, sex, halothane genotype, test, slaughter date, interaction of breed × sex, and random effects of sire and dam within breed. Breed significantly affected the concentration of individual fatty acids, total lipid content, and the values of several fatty acid indices of LM. Duroc pigs had the greatest (P< 0.01) content of total SFA. Total MUFA concentration in Poland China pigs was greater (P < 0.05) than in all other breeds except the Spotted (P> 0.05). The concentrations of total PUFA were greater (P < 0.01) in Hampshire, Landrace, and Yorkshire pigs compared with those of other breeds. Significant sex differences for individual fatty acids were detected. Compared with gilts, barrows had greater (P < 0.01) concentrations of SFA and MUFA but lower (P < 0.01) total PUFA. Halothane genotype was a significant source of variation for the percentages of some fatty acids. Pigs with the carrier (Nn) genotype had lower concentrations of SFA (P < 0.05) and MUFA (P < 0.01) but a greater concentration of PUFA (P < 0.01) compared with NN pigs. There were significant negative correlations between total lipid content and individual PUFA and significant positive correlations between lipid concentration and most individual SFA and MUFA. In conclusion, the results suggest that breed and sex are important sources of variation for fatty acid composition of LM. KeywordsBiochemistry Biophysics and Molecular Biology, breed, fatty acid, halothane genotype, longissimus muscle, pig, sex

show abstract

“…23 " 26 The metabolic effects responsible for this reduction appear to be very complex. 26 " 30 Based on the present findings, it is possible that changes in hepatic ACAT activity, by affecting cholesterol metabolism in the liver, could play some role in the plasma cholesterol response.…”

Section: Discussionmentioning

confidence: 99%

Dietary fat saturation and hepatic acylcoenzyme A:cholesterol acyltransferase activity. Effect of n-3 polyunsaturated and long-chain saturated fat.

Johnson¹,

Mathur²,

Spector³

1983

Arteriosclerosis

View full text Add to dashboard Cite

The acylcoenzyme A:cholesterol acyltransferase (ACAT) activity in liver microsomes from rats fed a diet containing 14% menhaden oil (M p ) for 11 days was 117% higher than that in microsomes from rats fed a corresponding diet containing 14% cocoa butter (M s ). There were no differences in the cholesterol and phospholipid contents of M p and M s or in the activities of palmitoyl coenzyme A hydrolase and NADPH cytochrome c reductase. NADPH-dependent lipid peroxidation was higher in M p , whereas glucose 6-phosphatase activity was higher in M s . These findings indicate that the ACAT response to differences in dietary fat saturation is not due to a nonspecific effect of these diets on microsomal enzymes. When 1% cholesterol was added to the diets, the cholesterol content and ACAT activity of both microsomal preparations increased, but the ACAT activity of M p remained 60% higher than that of M s . Addition of cholesterol by incubation of the microsomes with liposomes also increased ACAT activity. At corresponding cholesterol contents, however, the ACAT activity of M p remained 50% to 70% above that of M s . There was no difference in the plasma cholesterol concentration in the two groups of rats, indicating that the ACAT effect probably is not due to a difference in the amount of circulating cholesterol available to the liver. M p contained 40% more polyunsaturated fatty acids and five times more n-3 polyunsaturates than M s . These findings suggest that the increase in ACAT activity in M p is due, at least in part, to the difference in the fatty acid composition of the microsomes. (Arteriosclerosis 3:242-248, May/June 1983)

show abstract

Effects of Feeding Different Fats on Serum-Cholesterol Level

Cited by 380 publications

References 14 publications

Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls

Polymorphism of SREBP1 is associated with beef fatty acid composition in Simmental bulls

Effects of breed, sex, and halothane genotype on fatty acid composition of pork longissimus muscle1

Dietary fat saturation and hepatic acylcoenzyme A:cholesterol acyltransferase activity. Effect of n-3 polyunsaturated and long-chain saturated fat.

Contact Info

Product

Resources

About