Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding

Persinger, Aaron; Butawan, Matthew; Faietti, Martina; Pryke, Ashley; Rose, Kyley; Merwe, Mariè van der; Puppa, Melissa

doi:10.3390/nu13051717

Cited by 4 publications

(3 citation statements)

References 47 publications

(50 reference statements)

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“…The following genes were analyzed for expression: Cd36, Fabp3, Lipe, Fasn, and Crat. To isolate RNA from mouse liver and white and red gastrocnemius muscle, tissues were homogenized in 3-5 mL Trizol as previously described [35] and quantified using a Nanodrop (ThermoFisher Scientific, Waltham, MA, USA). For qPCR measurement of RNA transcripts, 1 µg of RNA was reverse-transcribed to cDNA.…”

Section: Rna Isolation and Qpcrmentioning

confidence: 99%

Effect of Omega-3 Rich High-Fat Diet on Markers of Tissue Lipid Metabolism in Glucocorticoid-Treated Mice

Son

Brown

Persinger

et al. 2023

IJMS

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Glucocorticoids (GCs) are some of the most widely prescribed therapies for treating numerous inflammatory diseases and multiple cancer types. With chronic use, GCs’ therapeutic benefits are concurrent with deleterious metabolic side effects, which worsen when combined with a high-fat diet (HFD). One characteristic of the common Western HFD is the presence of high omega-6 polyunsaturated fatty acids (PUFAs) and a deficiency in omega-3 PUFAs. The aim of this experiment was to determine whether fat composition resulting from HFD affects glucocorticoid-induced alterations in lipid-handling by the liver and skeletal muscle. Male wild-type C57BL/6 mice were randomized into two groups: n-6 (45% fat 177.5 g lard) and n-3 (45% fat 177.5 g Menhaden oil). After 4 weeks on their diets, groups were divided to receive either daily injections of dexamethasone (3 mg/kg/day) or sterile PBS for 1 week while continuing diets. The n-3 HFD diet attenuated adipose and hepatic fatty accumulation and prevented GC-induced increases in liver lipid metabolism markers Cd36 and Fabp. N-3 HFD had little effect on markers of lipid metabolism in oxidative and glycolytic skeletal muscle and was unable to attenuate GC-induced gene expression in the muscle. The present study’s result demonstrated that the change of fat composition in HFD could beneficially alter the fatty acid accumulation and associated lipid metabolism markers in mice treated with dexamethasone.

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Section: Rna Isolation and Qpcrmentioning

confidence: 99%

Effect of Omega-3 Rich High-Fat Diet on Markers of Tissue Lipid Metabolism in Glucocorticoid-Treated Mice

Son

Brown

Persinger

et al. 2023

IJMS

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“…Aligning meal times with the circadian rhythms by time-restricted feeding in animal models can also modulate PGC1α activity and mitochondrial biogenesis. [ 323 , 349 , 350 , 351 , 352 , 353 ]. Additionally, various polyphenolic compounds contribute to mitochondrial biogenesis via PGC1α activation, which is mediated via AMPK-SIRT1 activation [ 354 , 355 ].…”

Section: Mechanisms Of Chrononutrition In Energy Homeostasis and Obesitymentioning

confidence: 99%

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Ahluwalia

2022

Nutrients

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Obesity is a chronic and relapsing public health problem with an extensive list of associated comorbidities. The worldwide prevalence of obesity has nearly tripled over the last five decades and continues to pose a serious threat to wider society and the wellbeing of future generations. The pathogenesis of obesity is complex but diet plays a key role in the onset and progression of the disease. The human diet has changed drastically across the globe, with an estimate that approximately 72% of the calories consumed today come from foods that were not part of our ancestral diets and are not compatible with our metabolism. Additionally, multiple nutrient-independent factors, e.g., cost, accessibility, behaviours, culture, education, work commitments, knowledge and societal set-up, influence our food choices and eating patterns. Much research has been focused on ‘what to eat’ or ‘how much to eat’ to reduce the obesity burden, but increasingly evidence indicates that ‘when to eat’ is fundamental to human metabolism. Aligning feeding patterns to the 24-h circadian clock that regulates a wide range of physiological and behavioural processes has multiple health-promoting effects with anti-obesity being a major part. This article explores the current understanding of the interactions between the body clocks, bioactive dietary components and the less appreciated role of meal timings in energy homeostasis and obesity.

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“…TRF is a new intermittent restriction dietary pattern, which suggests that food is available only during the active phase without altering the nutritional composition of food. The defined period can vary from 8 to 12 h, which is enough to ensure sufficient calorie intake compared to ad libitum feeding ( 14 , 15 ). Compared to non-restricted diets, TRF has great advantages in preventing obesity, lowering blood pressure, and improving glucose intolerance in a high-fat diet (HFD)–induced obesity mouse model without changing daily caloric intake between TRF-treated and ad libitum –fed mice ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome

Han

Lin

et al. 2022

Front. Endocrinol.

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ObjectivesPolycystic ovary syndrome (PCOS) is one of the most common endocrinopathy disorders in premenopausal women, which is characterized by hyperandrogenemia, anovulation, and polycystic ovarian morphology (PCOM). Time-restricted feeding (TRF) is a new intermittent restriction dietary pattern, which has been shown to have positive benefits on obesity and glycolipid metabolism disorders. We aimed to explore the effect of the feeding regimen (ad libitum vs. TRF) on the glycolipid metabolism and reproductive endocrine disorders in a PCOS mouse model.MethodsPCOS mouse model was induced by continuous subcutaneous administration of dihydrotestosterone for 21 days. Mice were fed a high-fat diet (HFD) for 8 weeks on an ad libitum or time- restricted diet (from 10:30 p.m. to 6:30 a.m.).ResultsCompared to control mice, PCOS mice that received TRF treatment had significantly lower body weight, reduced adiposity, lower area under the curve (AUC) of glucose response in the oral glucose tolerance test (OGTT), and lower AUC in the insulin tolerance test (ITT). TRF also ameliorated lipid metabolism, as shown by a reduction in plasma lipid profiles (triglycerides and cholesterol) and the triglyceride content in the liver of PCOS mice. In terms of reproduction, the plasma androgen level, plasma estrogen (E2) level, and luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio in PCOS mice were significantly reduced after 8 weeks of TRF treatment. In addition, ovarian histology showed that TRF inhibits cyst formation and promotes corpus luteum formation.ConclusionIn conclusion, TRF improved metabolic and endocrine profiles in mice with PCOS.

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Effects of Feeding Time on Markers of Muscle Metabolic Flexibility Following Acute Aerobic Exercise in Trained Mice Undergoing Time Restricted Feeding

Cited by 4 publications

References 47 publications

Effect of Omega-3 Rich High-Fat Diet on Markers of Tissue Lipid Metabolism in Glucocorticoid-Treated Mice

Effect of Omega-3 Rich High-Fat Diet on Markers of Tissue Lipid Metabolism in Glucocorticoid-Treated Mice

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Time-restricted feeding improves metabolic and endocrine profiles in mice with polycystic ovary syndrome

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