Effects of Female Sex Hormones on Adhesion of Candida Albicans Yeast-Like Fungi to the Buccal Epithelium

Кравцов, Э. Г.; Anokhina, I. V.; Rybas, Ya. A.; Sachivkina, Nadezhda; Ermolaev, A. V.; Brodskaya, S. B.

doi:10.1007/s10517-014-2536-7

Cited by 5 publications

(5 citation statements)

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“…Latimer et al [75] reported that these changes are mainly due to the response to stress conditions. However, they also argued that these changes are potentially the consequence of changes in the expression of the intercellular polysaccharides, protein PIA, and Aap, or rather changes in the staphylococcal accessory regulator gene sarA, which controls several virulence determinants, including biofilm formation, hemolysins, and DNase [75][76][77][78]. Although similar observations have not been made with the O-ECB, we strongly recommend the use of antimicrobials in general at bactericidal doses to limit possible adaptations.…”

Section: Toxicity Screen and In Vivo Antibacterial Activity Of Agnps ...mentioning

confidence: 85%

Optimization of Ethanolic Extraction of Enantia chloranta Bark, Phytochemical Composition, Green Synthesis of Silver Nanoparticles, and Antimicrobial Activity

et al. 2022

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In this study, using the Box–Behnken model, we optimized the ethanolic extraction of phytochemicals from Enantia chloranta bark for the first time, assessed the composition with HPLC-MS/MS, performed the green synthesis of silver nanoparticles (AgNPs) and characterized them with UV-Vis spectrophotometry, photon cross-correlation spectroscopy, energy-dispersive X-ray fluorescence spectrometry, and Fourier transform infrared spectroscopy. The antibacterial and antibiotic-resistance reversal properties of optimized extract (O-ECB) and AgNPs were assessed on various microorganisms (15 Gram−, 7 Gram+, and 2 fungi) using the well diffusion method and microbroth dilution assay. The mechanism of action was investigated on growth kinetic and proton pumps of Escherichia coli. The in vivo antimicrobial activity and toxicity were assessed on Galleria mellonella larvae. The optimal mass yield (14.3%) related to the highest antibacterial activity (31 mm vs. S. aureus ATCC 6538) was obtained with the following operating conditions: % EtOH—100%; ratio m/v—20 g/mL; and extraction time—6 h. All the compounds identified in O-ECB were alkaloids and the major constituents were palmatine (51.63%), columbamine +7,8-dihydro-8-hydroxypalmatine (19.21%), jatrorrhizine (11.02%), and pseudocolumbamine (6.33%). Among the minerals found in O-ECB (S, Si, Cl, K, Ca, Mn, Fe, Zn, and Br), Br, Fe, and Cl were the most abundant with mean fluorescence intensities of 4.6529, 3.485,4, and 2.5942 cps/uA, respectively. The synthesized AgNPs revealed a strong absorption plasmon band between 430 and 450 nm and an average hydrodynamic diameter ×50 of 59.74 nm, and the presence of Ag was confirmed by a characteristic peak in the spectrum at the silver Kα line of 22.105 keV. Both O-ECB and AgNPs displayed noteworthy and broad-spectrum antimicrobial activities against 20/24 and 24/24 studied microorganisms, respectively, with recorded minimal inhibitory concentrations (MICs) ranging from 8 to ≥ 1024 µg/mL and 2 to 64 µg/mL. O-ECB and AgNPs showed antibiofilm properties and significantly enhanced the efficacy of conventional antibiotics against selected multidrug-resistant bacteria, and the mechanistic investigations revealed their interference with bacterial growth kinetic and the inhibition of H+-ATPase proton pumps. LD50s were 40 mg/mL and 0.6 mg/mL for O-ECB and AgNPs, respectively. In conclusion, the current study provides a strong experimental baseline to consider Enantia chlorantha bark and their green synthetized AgNPs as potent antimicrobial compounds in this era of antimicrobial resistance.

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Section: Toxicity Screen and In Vivo Antibacterial Activity Of Agnps ...mentioning

confidence: 85%

Optimization of Ethanolic Extraction of Enantia chloranta Bark, Phytochemical Composition, Green Synthesis of Silver Nanoparticles, and Antimicrobial Activity

et al. 2022

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“…The occurrence of genital candidiasis positively correlates with oestrogen levels, with oral contraceptives, hormone replacement treatment and pregnancy increasing the prevalence of Candida colonisation and vulvovaginal candidiasis (Spinillo et al, 1995;Bauters et al, 2002). Oestrogen levels have been implicated in regulating fungal morphogenesis and adhesion to the vaginal epithelium (Cheng et al, 2006;Kravtsov et al, 2014). However, the impact of oestrogen on the fungal cell wall has not been investigated.…”

Section: Environmental Impact On Cell Wall Carbohydratesmentioning

confidence: 99%

Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall

Hall

2015

Molecular Microbiology

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Summary C andida albicans is an opportunistic fungal pathogen of humans causing superficial mucosal infections and life‐threatening systemic disease. The fungal cell wall is the first point of contact between the invading pathogen and the host innate immune system. As a result, the polysaccharides that comprise the cell wall act as pathogen associated molecular patterns, which govern the host–pathogen interaction. The cell wall is dynamic and responsive to changes in the external environment. Therefore, the host environment plays a critical role in regulating the host–pathogen interaction through modulation of the fungal cell wall. This review focuses on how environmental adaptation modulates the cell wall structure and composition, and the subsequent impact this has on the innate immune recognition of C . albicans.

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“…A number of researchers [37] have identified the influence of hormonal levels on the adhesiveness of the buccal epithelium in women during the menstrual cycle: the most active adhesion of candidal cells to epithelial cells was observed in the follicular phase of the cycle. This phenomenon, like the effect of corticosteroids, according to some scientists [38,39], may be associated with increased keratinization -keratinization of cells under the influence of estrogenic hormones.…”

Section: Main Partmentioning

confidence: 99%

Modern View on the Issues of Immunological Tolerance of the Oral Mucosa

Bilozetskyi,

Radchuk,

Dzetsiukh

et al. 2023

VPBM

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Вісник проблем біології і медицини -2023 -Вип. 4 (171) / Bulletin of problems in biology and medicine -2023 -Issue 4 (171) 19 ОГЛЯДИ ЛІТЕРАТУРИ / LITERATURE REVIEWSand development mechanisms of periodontal tissue diseases at gastroesophageal reflux disease, bibliographic, analytical research methods and the method of systematic approach were used.Results. Recent publications show that the development of periodontitis is often caused by pathology of internal organs. High dental morbidity is observed at presence of the gastroduodenal zone diseases (chronic gastritis and duodenitis, duodenal ulcer). Inflammatory processes in the oral cavity may be the first clinical signs of disorders at diseases of the digestive system. The presence of somatic diseases in the human body makes a significant difference in the etiopathogenesis of periodontal diseases. Combined pathology is characterized by a mutually burdened course of diseases due to presence of close functional relationship between the affected organs. A number of researchers suggest that generalized periodontitis, despite sufficient monomorphism of clinical manifestations, is an etiologically and pathogenetically heterogeneous disease. Motor-tonic disorders of the esophagus against the background of lower sphincter dysfunction cause violation of the mineral composition and viscosity of saliva with the development of acidification (pH < 5.0) and, according to many scientists, trigger a cascade of dental damage at GERD.Conclusions. Thus, after analyzing the literature, it can be concluded that periodontal tissue lesions associated with gastroesophageal reflux disease have a wide range of clinical manifestations and an upward trend. Therefore, for the development of preventive measures, it is important to study in-depth the cause-and-effect relationships and mechanisms of periodontal tissue diseases at gastroesophageal reflux disease.

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Effects of Female Sex Hormones on Adhesion of Candida Albicans Yeast-Like Fungi to the Buccal Epithelium

Cited by 5 publications

References 1 publication

Optimization of Ethanolic Extraction of Enantia chloranta Bark, Phytochemical Composition, Green Synthesis of Silver Nanoparticles, and Antimicrobial Activity

Optimization of Ethanolic Extraction of Enantia chloranta Bark, Phytochemical Composition, Green Synthesis of Silver Nanoparticles, and Antimicrobial Activity

Dressed to impress: impact of environmental adaptation on the Candida albicans cell wall

Modern View on the Issues of Immunological Tolerance of the Oral Mucosa

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