Effects of femtosecond laser radiation on blood cell suspensions

Генинг, Т. П.; Sysolyatin, Aleksey; Абакумова, Т. В.; Arslanova, Dinara; Voronova, O S; Zolotovsky, Igor O.; Ostatochnikov, V. A.; Yavtushenko, M. S.

doi:10.1117/12.874492

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“…Thus, PBM causes an activation of the endogenous antioxidant defense systems and suppresses the action of reactive oxygen species generated in BALB/c Nude mice red blood cells immediately after laser exposure. This effect is consistent with the reported data highlighting the PBM-induced membrane-stabilizing effect and enhanced antioxidant blood properties reported earlier [49][50][51]. Thus, PBM stimulates the protective effect in red blood cells even at short exposure time and low irradiation dose (1.2 J/cm 2 ).…”

Section: Resultssupporting

confidence: 93%

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system

Долгова¹,

Абакумова²,

Генинг³

et al. 2019

Biomed. Opt. Express

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Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm 2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.

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Section: Resultssupporting

confidence: 93%