Effects of Fenoldopam Mesylate on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Foals

Hollis, A. R.; Ousey, Jennifer C.; Palmer, Leroy S.; Stoneham, Sarah J.; Corley, Kevin T.T.

doi:10.1892/0891-6640(2006)20[595:eofmos]2.0.co;2

Cited by 5 publications

(13 citation statements)

References 20 publications

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“…As in the previous experiment, 24 the techniques were well tolerated by the foals. Experimental periods immediately followed free-choice nursing from the mare, and the foals generally were somnolent or sleeping during the infusion periods.…”

Section: Resultssupporting

confidence: 68%

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Effects of Norepinephrine and a Combined Norepinephrine and Dobutamine Infusion on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Thoroughbred Foals

Hollis

Ousey

Palmer

et al. 2006

Veterinary Internal Medicne

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Background: Norepinephrine is a potent vasopressor that increases arterial blood pressure but may have adverse effects on renal blood flow. The combination of norepinephrine and dobutamine may lead to improved renal perfusion compared to an infusion of norepinephrine alone. The effects of these drugs in the normotensive neonatal foal have not been reported.Hypothesis: Norepinephrine increases arterial blood pressure. Adding dobutamine to a norepinephrine infusion will change the renal profile during the infusions without changing the arterial blood pressure.Animals: Eight conscious Thoroughbred foals were used in this study. Methods: Each foal received norepinephrine (0.1 mg/kg/min), combined norepinephrine (0.1 mg/kg/min) and dobutamine (5 mg/kg/min), and a control dose of saline in a masked, placebo-controlled study. Heart rate, arterial blood pressure (direct), and cardiac output (lithium dilution) were measured, and systemic vascular resistance, stroke volume, cardiac index, and stroke volume index were calculated. Urine output, creatinine clearance, and fractional excretion of sodium, potassium, and chloride were measured.Results: Norepinephrine and a combined norepinephrine and dobutamine infusion increased arterial blood pressure and systemic vascular resistance and decreased heart rate and cardiac index as compared to saline. The combination resulted in higher arterial pressure than norepinephrine alone. There was no significant difference in urine output, creatinine clearance, or fractional excretion of electrolytes with either infusion as compared to saline.Conclusions and Clinical Importance: These data suggest that norepinephrine and a combined norepinephrine and dobutamine infusion cause unique hemodynamic effects without affecting indices of renal function, and this effect warrants further investigation.

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Section: Resultssupporting

confidence: 68%

“…Cardiac output (CO) in liters per minute was determined by the lithium dilution method, as described. 23,24 Briefly, a bolus of 0.45 mmol lithium chloride was injected into the jugular vein via the jugular catheter. At the same time, blood was withdrawn from the metatarsal artery via the arterial catheter.…”

Section: Hemodynamic and Other Measurementsmentioning

confidence: 99%

Effects of Norepinephrine and a Combined Norepinephrine and Dobutamine Infusion on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Thoroughbred Foals

Hollis

Ousey

Palmer

et al. 2006

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…As in previous experiments with the same experimental design, 8,16 the techniques were well tolerated by the foals. Experimental periods immediately followed free-choice nursing from the mare, and the foals generally were somnolent or sleeping during the infusion periods.…”

Section: Resultssupporting

confidence: 65%

“…In normotensive foals, fenoldopam at 0.04 mg/kg/min increased urine output without affecting systemic hemodynamics. 16 Therefore, the addition of fenoldopam to another infusion may be expected to increase urine output. Norepinephrine may increase renal perfusion by increasing arterial blood pressure, leading to an increase in urine output.…”

Section: Discussionmentioning

confidence: 99%

Effects of Norepinephrine and Combined Norepinephrine and Fenoldopam Infusion on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Foals

Hollis

Ousey

Palmer

et al. 2008

Veterinary Internal Medicne

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Background: Norepinephrine increases arterial blood pressure but may have adverse effects on renal blood flow. Fenoldopam, a dopamine-1 receptor agonist, increases urine output in normotensive foals. The combination of norepinephrine and fenoldopam may lead to improved renal perfusion compared with an infusion of norepinephrine alone. The combined effects of these drugs have not been reported in the horse.Hypothesis: Norepinephrine will alter the hemodynamic profile of foals without affecting renal function. Addition of fenoldopam will change the renal profile during the infusions without changing the hemodynamic profile.Animals: Five conscious pony foals. Methods: Each foal received norepinephrine (0.3 mg/kg/min), combined norepinephrine (0.3 mg/kg/min) and fenoldopam (0.04 mg/kg/min), and a control dose of saline in a masked, placebo-controlled study. Heart rate (HR), arterial blood pressure (direct), and cardiac output (lithium dilution) were measured, and systemic vascular resistance (SVR), stroke volume, cardiac index (CI), and stroke volume index were calculated. Urine output, creatinine clearance, and fractional excretion of electrolytes were measured.Results: Norepinephrine and a combined norepinephrine and fenoldopam infusion increased arterial blood pressure, SVR, urine output, and creatinine clearance and decreased HR and CI compared with saline. The combination resulted in higher HR and lower arterial blood pressure than norepinephrine alone.Conclusions and Clinical Importance: Norepinephrine might be useful for hypotensive foals, because in normal foals, this infusion rate increases SVR without negatively affecting renal function (creatinine clearance increased). Fenoldopam does not provide additional benefit to renal function. These findings warrant further investigation.

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“…The low dose (0.04µg/kg/min) increased urine output without showing effects on haemodynamics or creatinine clearance, while the high dose did not affect renal function, but decreased blood pressure and increases in heart rate were noted (Hollis et al 2006a). The authors concluded that fenoldopam at low doses has the potential for prophylaxis and treatment of renal failure in critically ill foals, however, further studies are required until its use can be recommended.…”

Section: Fenoldopammentioning

confidence: 95%

Supportive care for the critically ill neonatal foal

Dunkel¹

2008

PHK

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Effects of Fenoldopam Mesylate on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Foals

Cited by 5 publications

References 20 publications

Effects of Norepinephrine and a Combined Norepinephrine and Dobutamine Infusion on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Thoroughbred Foals

Effects of Norepinephrine and a Combined Norepinephrine and Dobutamine Infusion on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Thoroughbred Foals

Effects of Norepinephrine and Combined Norepinephrine and Fenoldopam Infusion on Systemic Hemodynamics and Indices of Renal Function in Normotensive Neonatal Foals

Supportive care for the critically ill neonatal foal

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