Effects of fentanyl on cellular immune functions in man

Jacobs, Roland; Karst, Matthias; Scheinichen, Dirk; Bevilacqua, Carmine; Schneider, Udo; Heine, J.; Schedlowski, Manfred; Schmidt, Reinhold

doi:10.1016/s0192-0561(99)00025-9

Cited by 55 publications

(32 citation statements)

References 41 publications

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“…Fentanyl is known to enhance NK-cell cytotoxicity and increase NK and cytotoxic (CD8+) cell counts; however, the production of superoxide by PMNs and the number of circulating B-and T-lymphocytes remained unchanged in healthy volunteers [4,31]. These effects of fentanyl on NK cells seem to be more centrally mediated, as fentanyl does not affect NK-cell activity directly.…”

Section: Opioidsmentioning

confidence: 93%

Anti-Inflammatory Properties of Anesthetic Agents

Cruz

Rocco

Pelosi

2017

Annual Update in Intensive Care and Emergency Medicine

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Section: Opioidsmentioning

confidence: 93%

Anti-Inflammatory Properties of Anesthetic Agents

Cruz

Rocco

Pelosi

2017

Annual Update in Intensive Care and Emergency Medicine

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“…Although one experiment using an animal model indicated that a relatively high dose of fentanyl suppressed NK activity and resistance to tumor metastases [134], a clinically relevant dose of fentanyl augmented NK activity and increased the number of NK cells and CD8 + cytotoxic T lymphocytes in healthy volunteers [135]. In contrast, the quantities of circulating B and T lymphocytes remained unchanged in the presence of fentanyl [136]. Fentanyl has no ability to bind to μ3 receptors.…”

Section: Effects Of Opioids On Immune Cellsmentioning

confidence: 99%

Anesthetics, immune cells, and immune responses

2008

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General anesthesia accompanied by surgical stress is considered to suppress immunity, presumably by directly affecting the immune system or activating the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Along with stress such as surgery, blood transfusion, hypothermia, hyperglycemia, and postoperative pain, anesthetics per se are associated with suppressed immunity during perioperative periods because every anesthetic has direct suppressive effects on cellular and neurohumoral immunity through influencing the functions of immunocompetent cells and inflammatory mediator gene expression and secretion. Particularly in cancer patients, immunosuppression attributable to anesthetics, such as the dysfunction of natural killer cells and lymphocytes, may accelerate the growth and metastases of residual malignant cells, thereby worsening prognoses. Alternatively, the anti-inflammatory effects of anesthetics may be beneficial in distinct situations involving ischemia and reperfusion injury or the systemic inflammatory response syndrome (SIRS). Clinical anesthesiologists should select anesthetics and choose anesthetic methods with careful consideration of the clinical situation and the immune status of critically ill patients, in regard to long-term mortality, morbidity, and the optimal prognosis.

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“…The immunosuppressive properties of another potent opioid fentanyl have been shown to affect cellular immune responses in humans in a dose related manner (Jacobs et al, 1999& Beilin et al, 1996. In another study, patients with a long history of heroin intake when switched to high doses of buprenorphine showed significant immuno-suppression.…”

Section: Observations In Cases Of Therapeutic Use Of Opiates As Analgmentioning

confidence: 99%