Effects of ferroptosis in myocardial ischemia/reperfusion model of rat and its association with Sestrin 1

Feng, Yijun; Wang, Wei; Zhang, Shujun; Nong, Jifei; Zhang, Longdan

doi:10.17219/acem/153599

Cited by 9 publications

(8 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ferroptosis is a type of iron-dependent programmed cell death, characterized by accumulation of lipid peroxidation products and ROS. 65 LncRNA Mir9-3hg was found to be highly expressed in the exosomes derived from mouse BMSCs and downregulated in H/R-treated cells. 60 Exosomes from BMSCs promoted CMs proliferation, decreased iron ion concentration and ROS level, increased GSH content, and increased Gpx4 (ferroptosis marker protein) levels and decreased ACSL4 levels in H/ R-treated HL-1 mouse CMs, while were reversed by Mir9-3hg siRNA.…”

Section: Exosomal Mir9-3hgmentioning

confidence: 97%

“…Increasing studies suggested that MSCs‐derived exosomes might serve as safer alternative approach to cell therapy of MSCs transplantation in MI, which decreased infarcted size and improved cardiac function 64 . Several studies in vitro and in vivo demonstrated that exosomal lncRNAs derived from MSCs exerted important roles on CMs 53–62,65 …”

Section: Cms As Recipient Cells Of Exosomal Lncrnasmentioning

confidence: 99%

“…Ferroptosis is a type of iron‐dependent programmed cell death, characterized by accumulation of lipid peroxidation products and ROS 65 . LncRNA Mir9‐3hg was found to be highly expressed in the exosomes derived from mouse BMSCs and downregulated in H/R‐treated cells 60 .…”

Section: Cms As Recipient Cells Of Exosomal Lncrnasmentioning

confidence: 99%

“…64 Several studies in vitro and in vivo demonstrated that exosomal lncRNAs derived from MSCs exerted important roles on CMs. [53][54][55][56][57][58][59][60][61][62]65…”

Section: The Effects Of Mscs-derived Exosomal Lncrnas On Cmsmentioning

confidence: 99%

See 3 more Smart Citations

Extracellular lncRNAs secreted and absorbed by cardiomyocytes

Jiang

Lei

2023

J of Cellular Biochemistry

View full text Add to dashboard Cite

Exosomes are membrane‐surrounded extracellular vesicles released by almost all cell types, which mediate intercellular communications by delivering bioactive molecules from secretory cells to recipient cells. Long noncoding RNAs (lncRNAs) are a large class of non‐(protein)‐coding RNAs with lengths exceeding 200 nucleotides that are very active in the development of cardiovascular diseases (CVDs). Increasing evidence suggests that exosomal lncRNAs also play important roles in the progress of CVDs. We focus on the current available studies regarding these extracellular lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, hopefully providing a basis for deeper understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.

show abstract

Section: Exosomal Mir9-3hgmentioning

confidence: 97%

Section: Cms As Recipient Cells Of Exosomal Lncrnasmentioning

confidence: 99%

Section: Cms As Recipient Cells Of Exosomal Lncrnasmentioning

confidence: 99%

“…64 Several studies in vitro and in vivo demonstrated that exosomal lncRNAs derived from MSCs exerted important roles on CMs. [53][54][55][56][57][58][59][60][61][62]65…”

Section: The Effects Of Mscs-derived Exosomal Lncrnas On Cmsmentioning

confidence: 99%

See 2 more Smart Citations

Extracellular lncRNAs secreted and absorbed by cardiomyocytes

Jiang

Lei

2023

J of Cellular Biochemistry

View full text Add to dashboard Cite

show abstract

“…For instance, Sestrin2 levels were found to be elevated in ischemic cardiomyocytes [36] and in cardiac macrophages during reperfusion-induced myocardial infarction [37]. However, myocardial ischemia/reperfusion injury was also reported to downregulate Sestrin1 expression in cardiomyocytes [38]. In response to pressure overload, Sestrin2 expression was significantly increased in mouse hearts during early phases, but this reverted back to normal levels at 8 weeks [39].…”

Section: Regulation Of Sestrin Expression In the Heartmentioning

confidence: 99%

Muscular Sestrins: Roles in Exercise Physiology and Stress Resistance

Hwang

Kim

2023

Biomolecules

View full text Add to dashboard Cite

Sestrins are a family of stress-inducible proteins that are critical for stress adaptation and the maintenance of metabolic homeostasis. High expression of Sestrins is observed in skeletal and cardiac muscle tissues, suggesting their significance in the physiological homeostasis of these organs. Furthermore, expression of Sestrins is dynamically controlled in the tissues, based on the level of physical activity and the presence or absence of stress insults. Genetic studies in model organisms have shown that muscular Sestrin expression is critical for metabolic homeostasis, exercise adaptation, stress resistance, and repair and may mediate the beneficial effects of some available therapeutics. The current minireview summarizes and discusses recent findings that shed light on the role of Sestrins in regulating muscle physiology and homeostasis.

show abstract