Effects of Ferulic Acid on the Impairment of Inhibitory Avoidance Performance in Rats

Hsieh, Μing-Tsuen; Tsai, Fan-Hsiu; Lin, Ying-Chih; Wang, Wen-Hsin; Wu, Chi‐Rei

doi:10.1055/s-2002-33800

Cited by 24 publications

(15 citation statements)

References 13 publications

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“…The b-amyloid-and scopolamine-treated mice showed increased reaction times in a spatial memory test (water maze test), but the application of the T. aestivum extract reversed this effect. The total dietary fibre from T. aestivum L. effectively inhibited an Ab [25][26][27][28][29][30][31][32][33][34][35] -induced decrease in the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The authors concluded that the attenuation of the cytotoxicity and the memory deficits caused by scopolamine could be attributed to the presence of phenolic acids in T. aestivum L.…”

Section: Resultsmentioning

confidence: 99%

“…Sodium ferulate partly reduced the decrease in phosphorylated extracellular signal-regulated kinases ERK1 and ERK2 and completely reversed the decrease in phosphorylated Akt/protein kinase B induced by b-amyloid- (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) in the hippocampal regions of the rat brain (66). Also, sodium ferulate inhibited a b-amyloid-(1-40)-induced increase in phosphorylated-p38 mitogen-activated protein kinase (MKK3/MKK6), partly prevented a decrease in phosphorylated MAPKAPK2 and Hsp27 expression, and inhibited the activation of caspase cascades (caspase-3, caspase-7 and caspase-3 activities) (67).…”

Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning

confidence: 95%

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Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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Anticholinesterase activities of mashes produced using wheat ('Wheat Pale') or barley malts ('Pilsner', 'Pale Ale', 'Munich Light', 'Carahell' or 'Carared') were studied by spectrophotometric method. The highest inhibition of acetylcholinesterase and butyrylcholinesterase was observed at 52 C and/or 64 C, followed by a decrease or stabilization of the activity at 72 C. Changes in the total phenolics content in the test mashes were correlated with changes in the acetylcholinesterase and/or butyrylcholinesterase activities. Phenolic acids were singled out from phenolic compounds for more detailed studies owing to their simplicity and structural similarity to well-known cholinesterase inhibitors. The main phenolic acids in the test malts were ferulic, gallic, p-coumaric and vanillic acids followed by chlorogenic, caffeic, syringic, p-OH-benzoic, sinapic and protocatechuic acids. The anticholinesterase activities of the phenolic acids were studied using model standard solutions at concentrations similar to the maximal content of these compounds in the test mashes. Among the phenolic acids, p-coumaric acid had the largest share in the anticholinesterase activity, even though it was present in the test mashes at a significantly lower concentration (~0.38 mM L À1 ) than ferulic acid (~1.00 mM L À1 ). Sinapic acid and p-OH-benzoic acid (0.03 and 0.01 mM L À1 , respectively) were equally efficient inhibitors as ferulic acid at~1.00 mM L À1 . This preliminary study should be extended to other phenolic compounds from malt (wort) in the near future.

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Section: Resultsmentioning

confidence: 99%

Section: Phenolic Acids As Efficient Ache and Bche Inhibitorsmentioning

confidence: 95%

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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“…Recently, it has been reported that the long-term administration ferulic acid acts to protect against Ab 1-42 -induced neurotoxicity and memory disturbance 13) as well as learning and memory impairment induced by scopolamine or cycloheximide. 14,15) Previous reports have hypothesized that oxidative stress is one of the mechanisms of Ab-induced 1044 Vol. 27, No.…”

Section: Discussionmentioning

confidence: 99%

Effects of Pre-Germinated Brown Rice on .BETA.-Amyloid Protein-Induced Learning and Memory Deficits in Mice

Mamiya

Asanuma

Kise

et al. 2004

Biological & Pharmaceutical Bulletin

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We evaluated the effects of pre-germinated brown rice (hatsuga genmai, PGR) on learning and memory and compared them with those of polished rice or cornstarch. In mice that were fed pellets of polished rice or PGR for two weeks, the learning ability in the Morris water maze test was significantly enhanced compared with mice that were fed cornstarch pellets. In the Y-maze test, the intake of food pellets for two weeks failed to affect spontaneous alternation behavior.

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“…Suspensions of RSV and PCT were prepared by triturating the weighed amount of RSV (5, 10 & 15 mg/kg) and PCT (200 mg/ kg) in 0.5% carboxy methyl cellulose (CMC) suspension (w/v) in normal saline, respectively [29,30]. High salt saline was prepared freshly by adding 2% w/v NaCl in water.…”

Section: Drug Preparationmentioning

confidence: 99%

Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2–ARE pathway

et al. 2018

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Objective: The objectives of our study were to investigate the possible effect of rosuvastatin in ameliorating high salt and cholesterol diet (HSCD)-induced cognitive impairment and to also investigate its possible action via the Nrf2-ARE pathway. Methods: In silico studies were performed to check the theoretical binding of rosuvastatin to the Nrf2 target. HSCD was used to induce cognitive impairment in rats and neurobehavioral studies were performed to evaluate the efficacy of rosuvastatin in enhancing cognition. Biochemical analyses were used to estimate changes in oxidative markers. Western blot and immunohistochemical analyses were done to check Nrf2 translocation. TUNEL and caspase 3 tests were performed to evaluate reversal of apoptosis by rosuvastatin. Results: Rosuvastatin showed good theoretical affinity to Nrf2, significantly reversed changes in oxidative biomarkers which were induced by HSCD, and also improved the performance of rats in the neurobehavioral test. A rise in nuclear translocation of Nrf2 was revealed through immunohistochemical analysis and western blot. TUNEL staining and caspase 3 activity showed attenuation of apoptosis. Discussion: We have investigated a novel mechanism of action for rosuvastatin (via the Nrf2-ARE pathway) and demonstrated that it has the potential to be used in the treatment of cognitive impairment. KEYWORDSCognitive impairment; rosuvastatin; high-salt and cholesterol diet; oxidative stress; Nrf2; nuclear factor (erythroid-derived 2)-like 2

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Effects of Ferulic Acid on the Impairment of Inhibitory Avoidance Performance in Rats

Cited by 24 publications

References 13 publications

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Effects of Pre-Germinated Brown Rice on .BETA.-Amyloid Protein-Induced Learning and Memory Deficits in Mice

Rosuvastatin alleviates high-salt and cholesterol diet-induced cognitive impairment in rats via Nrf2–ARE pathway

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