Effects of fisetin on ethanol-induced rewarding properties in mice

Yalniz, Yasin; Yunusoğlu, Oruç; Berköz, Mehmet; Demirel, Mustafa Enes

doi:10.1080/00952990.2023.2292976

Cited by 1 publication

(1 citation statement)

References 71 publications

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“…Fisetin was first dissolved in 0.1% (v/v) DMSO and then diluted with physiological saline (0.9%) such that the total administered volume was in 0.9% physiological saline [23]. Mice were pre-treated with Fisetin (20 mg/kg/d) [23,24] for 7 days before DVT surgery and the vehicle groups were treated with 0.9% physiological saline for 7 days before DVT surgery. The Fisetin and vehicle were administered intragastrically (i.g.)…”

Section: Experimental Groupsmentioning

confidence: 99%

Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway

Liu,

2024

IJMS

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Oxidative stress and inflammation play pivotal roles in the progression of deep vein thrombosis (DVT). Fisetin has demonstrated promising pharmacological features; however, its underlying mechanisms in DVT remain elusive. In our study, we investigated the effects and underlying mechanisms of Fisetin on a DVT mouse model. The protective effects of Fisetin on DVT were evaluated by comparing the size of thrombosis and detecting the mRNA expression levels of pro-inflammatory cytokines. After that, the biological processes were studied via transcriptomics after Fisetin administration. The antioxidant effect was evaluated and explained via NRF2 signaling pathway. Finally, the anti-inflammatory effect was explained according to KEGG analysis and the final mechanism was verified via Western blot. Our results found that the mRNA expression levels of pro-inflammatory cytokines were inhibited by Fisetin. Moreover, transcriptomic studies suggested that MAPK signaling pathway may be associated with the anti-inflammatory activity of Fisetin. Then, we confirmed that Fisetin administration significantly inhibited the activation of typical pro-inflammatory signaling pathways via Western blot. Finally, the results of Western blot showed that Fisetin significantly activated NRF2 signaling pathway and induced the expression of downstream antioxidant enzymes. Our findings suggested that Fisetin exhibits potential therapeutic effects on DVT through its ability to attenuate inflammation and oxidative stress. The underlying mechanism may involve the suppression of MAPK-mediated inflammatory signaling pathway and activation of NRF2-mediated antioxidant signaling pathway.

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Section: Experimental Groupsmentioning

confidence: 99%

Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway

Liu,

2024

IJMS

View full text Add to dashboard Cite

show abstract

Effects of fisetin on ethanol-induced rewarding properties in mice

Cited by 1 publication

References 71 publications

Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway

Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway

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