Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial

Kuszewski, Julia C; Wong, Rachel H. X.; Wood, Lisa G.; Howe, Peter

doi:10.1016/j.numecd.2019.12.010

Cited by 30 publications

(32 citation statements)

References 35 publications

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“…There is evidence from in vitro studies showing that fish oil can reduce IL-1 in bovine chondrocytes and decrease inflammation-induced destruction of tissue in human OA cartilage harvested during surgical procedures [10]. In our study, fish oil supplementation slightly reduced the inflammatory marker CRP [ 14 ], but the reduction was not significant and was not correlated with a reduction in pain symptoms. However, one limitation of this study is that we did not measure other inflammatory markers involved in OA, such as IL-1 or TNF-α, which might have been more sensitive.…”

Section: Discussioncontrasting

confidence: 62%

“…Between June 2017 and August 2018, 152 participants were enrolled, of whom 134 completed the intervention, and after setting the compliance to 80%, 126 participants remained (for CONSORT diagram, see Kuszewski et al . [ 14 ]). Side effects were reported in four participants (digestive problems: PL n = 1, CUR n = 1 and FO+CUR n = 1; reflux: PL n = 1), but no serious adverse events were reported.…”

Section: Resultsmentioning

confidence: 99%

“…A detailed description of the study procedures has been published [ 14 ]. Briefly, participants attended the research facility a total of four times (two in the beginning and two at the end of the intervention), having refrained from medication, food and beverages other than water for ≥2 h before the visit.…”

Section: Methodsmentioning

confidence: 99%

“…This is a retrospective exploratory analysis of secondary outcomes in our previously published clinical trial [ 14 ]. To detect a 0.7 effect size (Cohen’s d ) difference between treatment groups in the primary outcome (cerebrovascular responsiveness to hypercapnia) at α = 0.05, an estimated 136 participants were needed.…”

Section: Methodsmentioning

confidence: 99%

“…We recently reported the effects of a 16-week supplementation trial of fish oil and/or curcumin on systemic and cerebral vascular function (with the primary outcome of cerebrovascular responsiveness to hypercapnia) and inflammation (CRP) in overweight/obese sedentary older adults [ 14 ]. In the same study, we tested the effects of fish oil and curcumin, independently and in combination, on self-reported chronic pain and OA burden, and whether any reductions in chronic pain would be related to enhanced microvascular function and reduced inflammation and accompanied by improvements in well-being (including general health perception, mood and depressive symptoms).…”

Section: Introductionmentioning

confidence: 99%

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Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Kuszewski

Wong

Howe

2020

Rheumatology Advances in Practice

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Objectives Osteoarthritis (OA) is a leading cause of chronic pain and disability. Next to inflammation, vascular pathology has been hypothesised to play a role in its etiology and progression. Due to side effects and low efficacy of pharmacological treatments, dietary supplements are popular as alternative treatments, but evidence of efficacy is limited. We tested whether fish oil and curcumin supplementation can reduce chronic pain and OA burden in older adults. Methods A 16-week randomized, double-blind, placebo-controlled, 2x2 factorial design supplementation trial with fish oil (2000mg docosahexaenoic acid + 400mg eicosapentaenoic acid/day), curcumin (160mg/day) or a combination of both was undertaken in sedentary overweight/obese older adults. Secondary outcomes included treatment changes in self-reported chronic pain and OA burden and whether changes are related to changes in small artery elasticity (surrogate marker for microvascular function), C-reactive protein (inflammatory marker) and well-being. Results The majority of participants (131/152) reported chronic pain, which was predominantly OA-specific. Fish oil significantly reduced OA-specific pain (P = 0.002, Cohen’s d = 0.56) and burden (P = 0.015, Cohen’s d = 0.45) compared to no fish oil treatment; reductions correlated with improvements in microvascular function and well-being. Curcumin, alone or in combination with fish oil, did not reduce pain measures. Conclusion Our findings indicate potential for fish oil to alleviate OA pain and burden in overweight/obese older adults. Further investigations should be undertaken in patients with clinically diagnosed OA to evaluate fish oil alone and as an adjunct to conventional pharmacotherapy and to investigate underlying mechanisms.

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Section: Discussioncontrasting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Kuszewski

Wong

Howe

2020

Rheumatology Advances in Practice

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Krill Lecithin as Surfactant for Preparation of Oil/Water Nanoemulsions as Curcumin Carriers

Velasco

Rascón

Calvo

et al. 2021

Euro J Lipid Sci & Tech

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Curcumin is a component in Curcuma longa L. with documented bioactive properties but has low bioavailability. To overcome this problem, curcumin nanoemulsions are prepared employing omega-3-rich phospholipids from krill oil as a surfactant and serve as curcumin carrying systems. The phospholipids are obtained through aqueous (LAD) and ethanolic (LED) degumming processes. The data obtained shows that LAD has a recovery of 70.7 ± 0.51% (w/w) phospholipids, being more efficient than LED with 45.97 ± 1.27% (w/w). Also, a higher content of omega-3 fatty acids is found in LAD with 36 ± 2.14% (w/w). From the critical micellar concentration (CMC) as an assessment of emulsifying capability, it is found that the krill oil (KO), LAD, and LED has a CMC in the range 0.666-0.700 g L −1 . Two formulations with different surfactant levels are developed: experiment A with 9.5% and experiment B with 4.75% (w/w) of krill lecithin are obtained by aqueous degumming. In the formulation of nanoemulsions average particle sizes of 139 ± 2.5 and 142 ± 5.3 nm are produced for experiments A and B, respectively. These results indicate that krill lecithin is an omega-3 rich good surfactant which can be employed to encapsulate curcumin. Practical applications: An interest has emerged in the food industry to develop surfactants with nutritional value. Phospholipids are natural emulsifiers that are widely used to form nanoemulsions because of their elevated interfacial activity. Krill oil has been reported to be an important source of phospholipids and omega-3 fatty acids, which are mainly esterified to phospholipid moieties. Because of these properties, krill oil phospholipids could form micelles and function as carrier systems for bioactive compounds, thus increasing their permeability in the intestine. Consequently, the present work focused on obtaining a nanostructure using a natural surfactant that possesses fatty acids with nutritional value such as omega-3 fatty acids. This will provide an added value to the product obtained, as well as improve the bioavailability of non-polar bioactive compounds. The results obtained could justify the use of krill oil as a useful functional food additive.

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Protective Effects of Curcumin on Endothelium: An Updated Review

Alidadi

Liberale

Montecucco

et al. 2021

Advances in Experimental Medicine and Biology

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Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled trial

Cited by 30 publications

References 35 publications

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Fish oil supplementation reduces osteoarthritis-specific pain in older adults with overweight/obesity

Krill Lecithin as Surfactant for Preparation of Oil/Water Nanoemulsions as Curcumin Carriers

Protective Effects of Curcumin on Endothelium: An Updated Review

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