Effects of five different alcoholic drinks on patients with Crohn's disease

Hey, Henrik; Schmedes, Anne; Nielsen, A.A.; Winding, P.; Grønbæk, Henning

doi:10.1080/00365520701452241

Cited by 24 publications

(14 citation statements)

References 14 publications

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“…The main hypothesis as to how alcohol could affect the luminal immune system is by increasing intestinal permeability and antigen exposure which has been shown previously in animal models (Tamai et al, 2000). Another possible explanation is that alcoholic beverages cause an osmotic diarrhea due to a high sugar content as has also been previously shown in CD (Hey et al, 2007). A retrospective questionnaire study such as this one is not able to differentiate between these hypotheses, and further studies are needed to examine these findings.…”

Section: Discussionmentioning

confidence: 58%

“…In that cohort, patients that had a relapse or disease flare over that year consumed 14 grams of alcohol daily compared to 10 grams daily in non-relapsers. In CD, the acute effects of five alcoholic drinks in inactive CD showed that those drinks associated with increased plasma glucose levels but not increased ethanol were associated with worsening GI symptoms (Hey et al, 2007). …”

Section: Discussionmentioning

confidence: 99%

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Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease

Swanson

Sedghi

Farhadi

et al. 2010

Alcohol

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Alcohol consumption is a potential trigger for flare in Inflammatory Bowel Disease (IBD) flare because of alcohol’s pro-oxidant effects and its deleterious effects on gut barrier function. The association with alcohol consumption and IBD flare is unclear. To test this hypothesis, we evaluated the pattern of alcohol consumption and its self-reported effect on gastrointestinal (GI) symptoms in patients with IBD. We recruited 129 consecutive patients: 52 patients with Crohn’s Disease, 38 patients with Ulcerative Colitis, and 39 patients with Irritable Bowel Syndrome (IBS). All participants completed a validated questionnaire on disease activity, the CDAI or UCAI respectively, validated questionnaires to quantify alcohol consumption by NIAAA criteria, and two structured questionnaires we designed to access patients’ perception of the effect of alcohol on their GI symptoms and on overall GI symptom severity. The pattern of current, light, moderate, and heavy alcohol consumption in inactive IBD was similar to the general US population. Specifically, 56 of 90 (62%) of inactive IBD patients were current drinkers, compared to 61% in the general US population. Of current drinkers, 75% of IBD (N=42), and 43% of IBS (N=9) reported a worsening of GI symptoms with alcohol consumption (p=0.01); however, overall GI symptom severity did not differ when compared to quantity of alcohol consumed. Patients with inactive IBD drink alcohol in quantities similar to the general population. Current drinkers with inactive IBD are more likely to report worsening of GI symptoms with alcohol than current drinkers with IBS.

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Section: Discussionmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease

Swanson

Sedghi

Farhadi

et al. 2010

Alcohol

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“…However, abdominal pain manifestations were detected in CD patients after consumption of Smirnoff Ice and Elephant beer with high glucose concentration. This suggests that fermentation could be responsible of intestinal bacteria overgrowth, thus playing a role in abdominal pain and intestinal damage in IBD [88].…”

Section: Effects Of Wine On Intestinal Damagementioning

confidence: 99%

Wine consumption and intestinal redox homeostasis

et al. 2014

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Regular consumption of moderate doses of wine is an integral part of the Mediterranean diet, which has long been considered to provide remarkable health benefits. Wine׳s beneficial effect has been attributed principally to its non-alcoholic portion, which has antioxidant properties, and contains a wide variety of phenolics, generally called polyphenols. Wine phenolics may prevent or delay the progression of intestinal diseases characterized by oxidative stress and inflammation, especially because they reach higher concentrations in the gut than in other tissues. They act as both free radical scavengers and modulators of specific inflammation-related genes involved in cellular redox signaling. In addition, the importance of wine polyphenols has recently been stressed for their ability to act as prebiotics and antimicrobial agents.Wine components have been proposed as an alternative natural approach to prevent or treat inflammatory bowel diseases. The difficulty remains to distinguish whether these positive properties are due only to polyphenols in wine or also to the alcohol intake, since many studies have reported ethanol to possess various beneficial effects. Our knowledge of the use of wine components in managing human intestinal inflammatory diseases is still quite limited, and further clinical studies may afford more solid evidence of their beneficial effects.

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“…One prospective cohort study on the effects of diet in UC found that patients with diets high in either alcohol or meat were at higher risk for flare over the next year [11]. Another study in CD found no difference in alcohol absorption or abdominal pain from five different alcoholic drinks [12], and concluded that it is likely the high sugar content that is responsible for reported symptoms. In addition, we recently reported on a cohort study using a survey analysis of alcohol consumption in inactive IBD, and found that patients with IBD do drink alcohol in a similar pattern to the general population, but were also more likely to report that alcohol worsens their gastrointestinal (GI) symptoms than patients with irritable bowel syndrome [13].…”

Section: Introductionmentioning

confidence: 99%

Is Moderate Red Wine Consumption Safe in Inactive Inflammatory Bowel Disease?

et al. 2011

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Background: Alcohol consumption is a potential trigger for inflammatory bowel disease (IBD) flare because of alcohol-induced oxidative stress and its deleterious effects on gut barrier function. Additionally, we have recently shown that alcohol consumption is associated with more symptoms in IBD. However, it is not known whether moderate daily alcohol consumption can modify IBD disease activity. To test what effects alcohol may have on patients with IBD, we evaluated the effect of moderate daily red wine for 1 week on two factors associated with recurrent IBD disease activity: intestinal permeability and stool calprotectin. Methods: To assess the effects of moderate daily alcohol consumption on intestinal permeability and inflammation, we recruited 21 patients: 8 with inactive ulcerative colitis (UC), 6 with inactive Crohn’s disease (CD), and 7 healthy controls. All participants with IBD completed a validated questionnaire on disease activity (Crohn’s disease activity index or ulcerative colitis clinical activity index), to confirm they had inactive disease. All subjects then underwent a baseline assessment that included a blood draw, urine collection after sugar challenge, and stool collection. Subjects then consumed 1–3 glasses of red wine a day for 1 week (approx. 0.4 g EtOH/kg), and repeated the three measures. Results: No subjects flared during the study. Moderate alcohol consumption did not significantly change either clinical disease activity scores or C-reactive protein. In contrast to healthy subjects, daily consumption of red wine significantly (1) decreased stool calprotectin in IBD subjects from baseline (p = 0.001) and (2) increased intestinal permeability as measured by urinary lactulose/mannitol excretion (marker of small bowel permeability) in CD (p = 0.028) or urinary sucralose secretion (marker of large bowel permeability) in UC (p = 0.012). Conclusions: One week of moderate consumption of red wine in inactive IBD was associated with a significant decrease in stool calprotectin and a significant increase in intestinal permeability. Our data suggests that patients with inactive IBD who drink red wine daily may be at an increased long-term risk for disease relapse.

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Effects of five different alcoholic drinks on patients with Crohn's disease

Abstract: The present study shows no difference in alcohol absorption between CD patients and controls. The alcoholic drinks Smirnoff Ice and Elephant beer have an increased effect on self-reported abdominal pain in CD patients, probably due to the high sugar content in these drinks.

Cited by 24 publications

References 14 publications

Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease

Pattern of alcohol consumption and its effect on gastrointestinal symptoms in inflammatory bowel disease

Wine consumption and intestinal redox homeostasis

Is Moderate Red Wine Consumption Safe in Inactive Inflammatory Bowel Disease?

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