Effects of flavonoid-rich extract from seeds of Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice

Sharma, Bhavna; Gunda, Viswanath; Salunke, Rajani; Roy, Partha

doi:10.1016/j.foodchem.2008.02.068

Cited by 85 publications

(93 citation statements)

References 25 publications

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“…In fact, ubiquitous plant polyphenols such as flavonoids, have exhibited a variety of pharmacological activities, including the anti-atherogenesis effect, and their role in prevention of coronary heart disease including atherosclerosis (Harnafi, ET Al.,2007), and have been demonstrated to inhibit lipid peroxidation, and increasing glutathione peroxidase concentrations that have been shown to play a protective role against oxidative damage in various tissues by neutralizing reactive oxygen species ( Wellwood ET Al.,2004& Olaleye ET Al.,2008. Further, several authors have also reported that flavonoids have hypolipidemic and hypocholesteromic effects ( Sharma ET Al., 2008). Another study has shown that flavonoids could reduce oxidized LDL in human and make LDL less susceptible to oxidative stress, and also flavonoids could recycle α-tocopherol by donating a hydrogen atom to the α-tocopherol radical, and thereby, delay the onset of lipid peroxidation.…”

Section: Journal Of Biology and Life Sciencementioning

confidence: 98%

“…Spleens were removed aseptically and homogenized in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum in the presence of HEPES, antibiotics and glutamine (Sharma ET Al., 2008). The viability of splenocytes was assessed by the trypan blue dye exclusion method (Sahu ET Al,.…”

Section: Colorimetric Mtt Assay For Con A/lps-induced Splenocyte's Prmentioning

confidence: 99%

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The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(-68.57%), low density lipoprotein (LDL) (-56.34%), and triglycerides (TG) (-182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

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Section: Journal Of Biology and Life Sciencementioning

confidence: 98%

Section: Colorimetric Mtt Assay For Con A/lps-induced Splenocyte's Prmentioning

confidence: 99%

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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“…(Harborne and Williams, 2000).The health benefits of flavonoids are well known and are displayed as a remarkable range of biochemical and pharmacological properties (Middleton et al, 2000). Accumulating evidence shows that flavonoids have antioxidant, hypolipidaemia, soften the blood vessel, hypoglycaemia properties (Hollman et al, 1999)，and reduced risk for developing various cancers (Carroll et al, 1998;Sharma et al, 2008). But at present there is no study on the effect of flavonoids extracted from Ipomoea batatas leaf on diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

The optimal extraction parameters and anti-diabetic activity of flavonoids from <i>Ipomoea batatas</i> leaf

Li¹,

Li²,

Gao³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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Extraction parameters of flavonoids from Ipomoea batatas leaf (FIBL) and anti-diabetic activity of FIBL on alloxan induced diabetic mice were studied. The optimal extraction parameters of FIBL were obtained by single factor test and orthogonal test, as follows: ethanol concentration 60 %, ratio of solvent to raw material 30 , extraction temperature 75 ℃ and extraction time 1.5 h , while extraction yield of FIBL was 5.94 %. FIBL treatment (50, 100, and 150 mg/ kg body weight) for 28 days resulted in a significant decrease in the concentration of fasting blood glucose (FBG), total cholesterol (TC) and triglyceride (TG) in diabetes mellitus mice. Furthermore, FIBL significantly increased body weight (bw) and serum high-density lipoprotein cholesterol (HDL-c) level. The data demonstrated FIBL at the dose of 100 mg/kg bw exhibited the optimal effect.The above results suggest that FIBL can control blood glucose and modulate the metabolism of blood lipid in diabetes mellitus mice.

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“…It has also been reported to prevent hyperglycemia associated diabetes through its mammalian intestinal α-glucosidase inhibitory activity (Lee & Sohn, 2008). The effect of ethanolic extract of Woodfordia fruticosa (WF) on blood glucose may be due to chemical constituent such as tannins, terpenoids, saponins and flavonoids reported to have antihyperglycemic effect (Matsudha et al, 2002;Kambouche et al, 2009;Sharma et al, 2008). Various compounds such as hecogenin, lupeol, oleanolic acid, ursolic acid, quercetin have also been isolated from W. fruticosa which enhances the importance of this plant.…”

Section: Resultsmentioning

confidence: 99%

Effect of Woodfordia fruticosa on dexamethasone induced insulin resistance in mice

Bhujbal¹,

Providencia²,

Nanda³

et al. 2012

Rev. bras. farmacogn.

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Diabetes is a group of syndrome characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins, resulting in an increased risk of complications from vascular disease. The fl owers of Woodfordia fruticosa (L.) Kurz, Lythraceae, have been used traditionally in the treatment of diabetes, dysentery, diarrhea, other bowel complaints, internal haemorrhages, in leucorrhoea and menorrhagia. Externally powdered fl ower is sprinkled over foul ulcers and wounds for diminishing their discharge and promoting granulations. In Konkan leaves are used in bilious sickness. W. fruticosa is also reported to have DNA topoisomerase inhibitor, antibacterial, antifertility, antipeptic ulcer, free radical scavenging, and hepatoprotective activity. W. fruticosa is a medicinal plant used to treat a wide range of disorder including diabetes. The present work investigates the effects of the WF in dexamethsone induced insulin resistance in mice. The results of animal study revealed that the extract at dose 100, 200 and 400 mg/kg was found to be signifi cant (p<0.01) after 22 days of treatment. Further isolation studies afforded an anthraquinone glycoside, chrysophanol-8-O-β-D-glucopyranoside. Moreover further experiments will be required to identify their exact mechanism of action.

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Effects of flavonoid-rich extract from seeds of Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice

Cited by 85 publications

References 25 publications

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

The optimal extraction parameters and anti-diabetic activity of flavonoids from <i>Ipomoea batatas</i> leaf

Effect of Woodfordia fruticosa on dexamethasone induced insulin resistance in mice

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