Effects of flavonoids on gastrointestinal disorders

Gálvez, Júlio; Medina, Fermín Sánchez de; Jiménez, J.; Zarzuelo, Antonio

doi:10.1016/s1572-5995(01)80019-3

Cited by 27 publications

(20 citation statements)

References 224 publications

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“…Studies in man have evaluated flavonoids for prophylaxis of cancer [4], cardiovascular [5], gastrointestinal [6], and neurological [7] disease. These studies are mostly concerned with effect of dietary flavonoid consumption and prevention of disease.…”

Section: Introductionmentioning

confidence: 99%

Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells

et al. 2010

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“…Previous studies have shown the beneficial effects of different antioxidant compounds in experimental models of rat colitis, including flavonoids like quercitrin, rutoside, morin, diosmin and hesperidin, 10) vitamin E 11) and tempol. 12) Recently, a natural antioxidant isocoumarin displaying chemical features similar those of flavonoids has been its protective effects described in a model of rat colitis.…”

mentioning

confidence: 99%

Intestinal Anti-inflammatory Activity of Coumarin and 4-Hydroxycoumarin in the Trinitrobenzenesulphonic Acid Model of Rat Colitis

Luchini

Rodrigues-Orsi

Cestari

et al. 2008

Biological & Pharmaceutical Bulletin

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Coumarins represent an important class of phenolic compounds with multiple biological activities, including inhibition of lipidic peroxidation and neutrophil-dependent anion superoxide generation, anti-inflammatory and immunosuppressor actions. All of these proprieties are essential for that a drug may be used in the treatment of inflammatory bowel disease. The present study examined intestinal anti-inflammatory activity of coumarin and its derivative, the 4-hydroxycoumarin on experimental ulcerative colitis in rats. This was performed in two different experimental settings, i.e. when the colonic mucosa is intact or when the mucosa is in process of recovery after an initial insult. The results obtained revealed that the coumarin and 4-hydroxycoumarin, at doses of 5 and 25 mg/kg, significantly attenuated the colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in both situations, as evidenced macroscopically, microscopically and biochemically. This effect was related to an improvement in the colonic oxidative status, since coumarin and 4-hydroxycoumarin prevented the glutathione depletion that occurred as a consequence of the colonic inflammation.

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“…The presence of flavonoids in carrot that reduces the gastric acidity may be due to two factors, H+ secretion inhibition and increase of prostaglandin formation. 10 Therefore when prostaglandin increases, it stimulates secretion of mucous and bicarbonate, maintains the mucosal blood flow and also mucosal cell turnover and repair. 7 The increase (or excess?)…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective Effect of Carrot (Daucus carota L.) Juice in Rat Models

Jiin¹,

Hidayat²,

Lukman³

2014

amj

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Background: Gastritis has become one of the very common gastrointestinal tract disorders in clinical practice. One of the factors causing gastritis is the prolonged intake of nonsteroidal anti-inflammatory drugs (NSAIDs) which is commonly adopted by people suffering pain. The NSAIDs such as aspirin cause loss of mucosal integrity resulting in gastric mucosa inflamation. Carrot (Daucus carota L.) has long been used as a traditional medicine for various ailments. The presence of flavonoids and carotenoids in carrot is associated with gastroprotective effect. Methods: The present study was undertaken to determine the gastroprotective effect of 4.08 g carrot juice administered by feeding tube on the hydrochloric acid (HCL) concentration in the stomach in aspirin-induced Wistar-strain rats. This was a laboratory experimental study performed at

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Effects of flavonoids on gastrointestinal disorders

Cited by 27 publications

References 224 publications

Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells

Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells

Intestinal Anti-inflammatory Activity of Coumarin and 4-Hydroxycoumarin in the Trinitrobenzenesulphonic Acid Model of Rat Colitis

Gastroprotective Effect of Carrot (Daucus carota L.) Juice in Rat Models

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