Effects of flavonoids on rat aortic smooth muscle contractility: Structure-activity relationships

Herrera, Marcelino; Zarzuelo, Antonio; Jiménez, J.; Marhuenda, E.; Duarte, Juan

doi:10.1016/0306-3623(95)02010-1

Cited by 109 publications

(99 citation statements)

References 20 publications

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“…21) For example, CA is a water-soluble antioxidant. [21][22][23] MO is a lipid-soluble antioxidant but it is weak, and a very wide range of biological actions of MO, including inhibitory activity against, oxidative modification of low-density lipoprotein 22) and a vasorelaxant effect, 23) have been reported. trans-RV in plasma is very sparse and shows a short half-life (8-14 min) because of its poor water-solubility and instability, as it converts to a cis form (a less active form).…”

Section: Discussionmentioning

confidence: 99%

“…CA is a widely distributed phenolic acid present in coffee and some fruits, and it is known as a water-soluble antioxidant, and it has been successfully encapsulated in low-cost, high-volume yeast cells for the first time. [20][21][22][23] MO is a flavonoid found in figs and other Moraceae, which are used as herbal medicines, and it is known as a major lipid-soluble antioxidant. [22][23][24] RV is a naturally occurring polyphenolic phytoalexin found in many plants and contained in foods and drinks such as in Mediterranean diets and French wine, and it is known as a poor water-soluble antioxidant.…”

mentioning

confidence: 99%

“…[20][21][22][23] MO is a flavonoid found in figs and other Moraceae, which are used as herbal medicines, and it is known as a major lipid-soluble antioxidant. [22][23][24] RV is a naturally occurring polyphenolic phytoalexin found in many plants and contained in foods and drinks such as in Mediterranean diets and French wine, and it is known as a poor water-soluble antioxidant. 25,26) Regarding concerns about the bioavailability of polyphenols, we examined the effects of short-term treatment with each polyphenol.…”

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confidence: 99%

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Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A<sub>2</sub> Levels in Streptozotocin-Induced Diabetic Mice

Taguchi

Hida

Matsumoto

et al. 2014

Biological & Pharmaceutical Bulletin

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Diabetes is characterized by the development of endothelial dysfunction, which affects both nitric oxide (NO)-mediated relaxation and endothelium-derived contracting factors, associated with vascular oxidative stress. There is a growing body of evidence suggesting that polyphenols have several beneficial effects, such as antioxidant and anti-inflammatory activities. This study investigated whether short-term treatment with polyphenols (chlorogenic acid (CA), morin (MO), resveratrol (RV)) can improve endothelial dysfunction related to diabetes. Aorta reactivity was determined in organ chambers, and we measured NO production and thromboxane B 2 (TXB 2 ; a metabolite of TXA 2 ) from aortas in response to acetylcholine (ACh). Streptozotocin (

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A<sub>2</sub> Levels in Streptozotocin-Induced Diabetic Mice

Taguchi

Hida

Matsumoto

et al. 2014

Biological & Pharmaceutical Bulletin

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“…Previous studies in our laboratories and elsewhere have shown that quercetin, kaempherol, morin, myricetin, luteolin and rutin, all present in PGE, possess vasodilator effects in rat isolated aorta and porcine coronary artery (Duarte et al, 1993a, b;Herrera et al, 1996;Perez-Vizcaíno et al, 2002;Ajay et al, 2003;Xu et al, 2007). In the present study, we report for the first time in biomedical literature, that Psidium guajava crude leaf aqueous extract, which contains many flavonoids, especially quercetin, induces vascular smooth muscle relaxation, with potency lower than that of pure quercetin (Chiwororo and Ojewole, 2008 -unpublished observation).…”

Section: Discussionmentioning

confidence: 93%

Biphasic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated vascular smooth muscles

Chiwororo

Ojewole

2008

J. Smooth Muscle Res.

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In this study, we examined the effects of Psidium guajava Linn. leaf aqueous extract (PGE) on isolated, spontaneously-contracting portal veins, as well as on endotheliumintact and endothelium-denuded descending thoracic aortic ring preparations of healthy, normotensive rats. Graded concentrations of PGE (0.25-4.0 mg/ml) caused concentration-dependent, initial brief but significant (P<0.05) rises of the basal tones and amplitudes of pendular, rhythmic contractions, followed by secondary pronounced, longer-lasting and significant (P<0.05-0.001) inhibitions of contractile amplitudes of the isolated portal veins. Relatively low concentrations of PGE (<1.0 mg/ml) always contracted freshly-mounted, naïve, endothelium-intact aortic ring preparations. However, relatively high concentrations of PGE (1.0-4.0 mg/ml) always produced initial brief contractions/augmentations of noradrenaline (NA, 10 -7 M)-induced contractions of endothelium-intact and endothelium-denuded aortic ring preparations, followed by secondary, pronounced relaxations of the aortic ring muscles. Moreover, relatively high concentrations of PGE (1.0-4.0 mg/kg) always relaxed NA-induced contractions of the aortic ring preparations in a concentration-related manner. The arterial-relaxing effects of PGE were more pronounced in endothelium-intact aortic rings than in endotheliumdenuded aortic ring preparations. The relaxant effects of PGE on endothelium-intact aortic rings were only partially inhibited by N G -nitro-L-arginine methyl ester (L-NAME, 100 µM), a nitric oxide synthase inhibitor, suggesting that the vasorelaxant effect of PGE on aortic rings is probably mediated via both endothelium-derived relaxing factor (EDRF)-dependent and EDRF-independent mechanisms. Taken together, the findings of this study indicate that PGE possesses a biphasic effect on rat isolated vascular smooth muscles.

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“…Myriecetin showed contractile and myorelaxant effects if used in low doses and high doses, respectively. (Herrera et al, 1996). Possibly the contractile effect of quercetin and luteolin used in low doses was missed by some authors who studied the effect of those flavonoids on smooth muscle contractility only in the range of doses 1 to 100 μM (Capasso et al, 1991a and1991b;Hammad and Abdalla, 1997; Amira et al, 2008).…”

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confidence: 99%

Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study

Mendel

Chłopecka

Dziekan

et al. 2016

animal

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Flavonoid supplementation is likely to be beneficial in improving rumen fermentation and in reducing the incidence of rumen acidosis and bloat. Flavonoids are also said to increase the metabolic performance during the peripartum period. Ruminants are constantly exposed to flavonoids present in feed. However, it is not clear if these phytochemicals can affect the activity of the gut smooth muscle. Therefore, the aim of the study was to verify the effect of three flavonoids on bovine isolated abomasum smooth muscle. The study was carried out on bovine isolated circular and longitudinal abomasal smooth muscle specimens. All experiments were conducted under isometric conditions. The effect of apigenin, luteolin and quercetin (0.001 to 100 µM) was evaluated on acetylcholine-precontracted preparations. The effect of multiple, but not cumulative, treatment and single treatment with each flavonoid on abomasum strips was compared. Apigenin (0.1 to 100 µM) dose-dependently showed myorelaxation effects. Luteolin and quercetin applied in low doses increased the force of the ACh-evoked reaction. However, if used in high doses in experiments testing a wide range of concentrations, their contractile effect either declined (luteolin) or was replaced by an antispasmodic effect (quercetin). Surprisingly, the reaction induced by flavonoids after repeated exposure to the same phytochemical was not reproducible in experiments testing only single exposure of abomasum strips to the same flavonoid used in a high concentration. Taking into account the physicochemical properties of flavonoids, this data suggests the ability of flavonoids to interfere with cell membranes and, subsequently, to modify their responsiveness. Assuming ruminant supplementation with luteolin or quercetin or their presence in daily pasture, a reduction of the likelihood of abomasum dysmotility should be expected.

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Effects of flavonoids on rat aortic smooth muscle contractility: Structure-activity relationships

Cited by 109 publications

References 20 publications

Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A<sub>2</sub> Levels in Streptozotocin-Induced Diabetic Mice

Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A<sub>2</sub> Levels in Streptozotocin-Induced Diabetic Mice

Biphasic effect of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract on rat isolated vascular smooth muscles

Modification of abomasum contractility by flavonoids present in ruminants diet: in vitro study

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