Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model

Ingram, Alistair J.; Parbtani, Anwar; Clark, William F.; Spanner, Evelyn; Huff, Murray W.; Philbrick, Diana J.; Holub, Bruce J.

doi:10.1016/0272-6386(95)90015-2

Cited by 54 publications

(26 citation statements)

References 33 publications

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“…Consistent with previously reported beneficial effects of soy protein and flax oil in animal models of early [2,3,4,5,6,7,8,9] as well as advanced renal disease [11, 12], the current study demonstrates that these dietary interventions retard some of the pathologies associated with renal injury when introduced in established kidney disease. Renal disease in the 2-month-old rats at the beginning of the dietary intervention in this study was analogous to stage 3 CKD.…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, most individuals diagnosed with CKD are not likely to consider a change in diet until histologic injury is already well advanced. In animal models of advanced renal injury caused by renal ablation, dietary interventions such as soy protein [11] and flaxseed and flax oil [12] are beneficial in retarding renal disease progression. Similar protective effects of dietary soy protein [13, 14] also have been suggested in humans with advanced nephropathies.…”

Section: Introductionmentioning

confidence: 99%

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Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Sankaran¹,

Bankovic-Calic²,

Cahill³

et al. 2007

Nephron Exp Nephrol

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Background/Aims: Dietary soy protein and flax oil retard kidney disease progression when initiated in the early stages of disease in several experimental models, including the Han:SPRD-cy rat. However, individuals with kidney disease often do not become aware of their condition until injury to the kidney is extensive. The objective of this study was to determine whether initiating these interventions in established disease would alter further progression of renal injury. Methods: Two-month-old adult male Han:SPRD-cy rats were given either a flax oil diet (7% flax oil), a soy protein diet (20% soy protein) or a control diet (7% corn oil, 20% casein) for 4 months. Renal disease progression was assessed by examining morphological, immunohistochemical and biochemical parameters. Results: Compared to controls, there was 21–24% less staining of proliferating cells, 21–24% less oxidative damage and 13–15% less renal inflammation in kidneys from rats given dietary soy protein and flax oil. Renal cystic growth and fibrosis and serum creatinine levels were not altered by these dietary treatments. Conclusions: Late intervention with dietary soy protein and flax oil reduces some disease-associated pathologies in established renal disease in Han:SPRD-cy rats. The potential benefits of the antioxidant and anti-inflammatory effects on ultimate renal disease outcome in the long term remains to be determined.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Sankaran¹,

Bankovic-Calic²,

Cahill³

et al. 2007

Nephron Exp Nephrol

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show abstract

“…Similarly, a significant attenuation in heart rates was observed in both treated groups (flaxseed and fish oils) as early as 12 wk. Consistent with our findings, fish and flaxseed oils resulted in attenuations in blood pressure in heart transplant recipients (3,20,52), hypertensive rats (29), and rats with renal ablation (22). The mechanism underlying hypertension-lowering effects of oils rich in n-3 FAs might be related, at least in part, to an induction of vasodilation due to an improved prostaglandin profile (12), inhibition of angiotensin-converting enzyme activity, reduction of angiotensin II production, or an improvement in endothelial nitric oxide production (33).…”

Section: Discussionsupporting

confidence: 91%

A comparison of the effects of fish oil and flaxseed oil on cardiac allograft chronic rejection in rats

Othman

Suh²,

Fischer³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

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“…The beneficial effects of flax oil given maternally are consistent with previous studies that reported amelioration of renal injury when flax oil intervention was introduced in the adult or postweaning stages (6,7,19). In cystic kidney diseases, recent evidence suggests that cyst expansion precedes the changes in function and is associated with the initiation of inflammation, fibrosis and other secondary changes (24).…”

Section: Discussionsupporting

confidence: 87%

“…Dietary interventions such as altering dietary fat sources slow the progression of chronic renal disease. Dietary n-3 fatty acids from fish and flax sources have been shown to be reno-protective, particularly in renal injury that has an immune and/or inflammatory component (3)(4)(5)(6)(7). These protective effects of n-3 fatty acids on renal disease progression in humans or animal models have been demonstrated in adult or weanling animals.…”

mentioning

confidence: 99%

Dietary Flax Oil During Pregnancy and Lactation Retards Disease Progression in Rat Offspring With Inherited Kidney Disease

et al. 2006

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Dietary flax oil (FO) retards disease progression in growing or adult animal models of kidney disease. To determine whether dietary flax oil during the perinatal period would alter renal disease progression in offspring, Han-SPRD-cy rats with inherited cystic kidney disease were given diets with either 7% FO or corn oil (CO), throughout pregnancy and lactation. At 3 wk of age, offspring were then given either the same or the alternate diet for 7 wk. Rats given FO during the maternal period had 15% less renal cyst growth compared with rats given FO only in the postweaning period. Dietary FO, compared with CO, in the maternal period also resulted in 12% lower cell proliferation and 15% less oxidant injury in diseased kidneys of offspring. Including FO in both the maternal and postweaning period resulted in 29 -34% less renal interstitial fibrosis and 22-23% lower glomerular hypertrophy. Along with improved histology, these rats exhibited 13% less proteinuria and 30% lower creatinine clearance when dietary FO was given in the maternal period. The potential for dietary FO during pregnancy and lactation to positively modulate adult renal disease has significant implications for the 1 in 1000 individuals with congenital cystic kidney disease.

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Effects of flaxseed and flax oil diets in a rat-5/6 renal ablation model

Cited by 54 publications

References 33 publications

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

Late Dietary Intervention Limits Benefits of Soy Protein or Flax Oil in Experimental Polycystic Kidney Disease

A comparison of the effects of fish oil and flaxseed oil on cardiac allograft chronic rejection in rats

Dietary Flax Oil During Pregnancy and Lactation Retards Disease Progression in Rat Offspring With Inherited Kidney Disease

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