Effects of fluoride and mercury on human cytokine response in vitro*1

Vos, Gabriele de; Jerschow, Elina; Liao, Zenghua; Rosenstreich, David L.

doi:10.1016/j.jaci.2003.12.209

Cited by 3 publications

(1 citation statement)

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“…The CD80/CD86-CD28 pathway has been shown to be bidirectional, whereby signaling by CD80 and CD86 on DCs results in the production of IFN and IL-6 [31]. Studies by de Vos et al [32] have provided solid evidence that NaF significantly suppressed Con A-induced IFN-gamma production of lymphocytes. Lund et al [33] have already described that IL-6 was significantly increased in the bronchial portion for those cells exposed to "high" concentrations fluoride.…”

Section: Discussionmentioning

confidence: 99%

Effect of Fluoride on Endocytosis and Surface Marker Expression Levels of Mouse B Cells In Vitro

Shi

Dong

et al. 2016

Cell Physiol Biochem

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Background/Aims: To clarify the effect of fluoride on splenic B cells, the endocytosis and surface marker expression levels of mouse splenic B cells were detected in vitro by flow cytometry. Methods: Cells were stimulated with 10 µg/mL lipopolysaccharide (LPS) and varying concentrations of Sodium Fluoride (NaF) (0, 50 µM, 100 µM, 500 µM, 1000 µM). Results: The results demonstrated that the endocytic capacity of B cells was enhanced by NaF at 50µM. NaF significantly enhanced CD80 expression at 50 µM and decreased CD86 expression at 500 µM. CD40 and CD138 expression on B cells were down-regulated at varying high concentrations of NaF. Conclusion: our results showed that the endocytic capacity, expression levels of CD40 and CD80 of B cells changed significantly at lower concentrations, whereas expression levels of CD138 and CD86 changed significantly at higher concentrations, suggesting that fluoride could inhibit immune function in animals.

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Section: Discussionmentioning

confidence: 99%

Effect of Fluoride on Endocytosis and Surface Marker Expression Levels of Mouse B Cells In Vitro

Shi

Dong

et al. 2016

Cell Physiol Biochem

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Mercury and metabolic syndrome: a review of experimental and clinical observations

Tinkov

Ajsuvakova

Skalnaya³

et al. 2015

Biometals

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A significant interrelation between heavy metal exposure and metabolic syndrome (MetS) development has been demonstrated earlier. Despite the presence of a number of works aimed at the investigation of the role of Hg in MetS development, the existing data remain contradictory. Therefore, the primary objective of the current work is to review the existing data regarding the influence of mercury on universal mechanisms involved in the pathogenesis of the development of MetS and its components. The brief chemical characterization of mercury is provided. The role of mercury in induction of oxidative stress has been discussed. In particular, Hg-induced oxidative stress may occur due to both prooxidant action of the metal and decrease in antioxidant enzymes. Despite the absence of direct indications, it can be proposed that mercury may induce endoplasmic reticulum stress. As it is seen from both in vivo and in vitro studies, mercury is capable of inducing inflammation. The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development. Moreover, multiple investigations have indicated the role of mercury in pathogenesis of MetS components: dyslipidemia, hypertension, insulin resistance, and obesity to a lesser extent. The present state of data regarding the interrelation between mercury and MetS denotes the following perspectives: (1) Further clinic-epidemiologic and experimental studies are required to estimate the association between mercury exposure and the development of MetS components, especially obesity; (2) Additional investigations of the possible effect of organism's mercury content modulation on MetS pathogenesis should be undertaken.

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Immunotoxic potential of sodium fluoride following subacute exposure in Wistar rats

Giri¹,

Ghosh²,

Mondal³

et al. 2013

Afr. J. Agric. Res.

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Fluoride pollution in drinking water is an international problem as the fluoride present is often at levels above acceptable limits. This study was done with an objective to determine the immunotoxic potential of sub acute exposure of sodium fluoride in Wistar rats with special reference to the Dinitroflurobenzene contact skin sensitivity test and pathological alterations in splenic histoarchitecture. The rats were intoxicated orally to sodium fluoride at dose levels of 5, 25 and 50 mg/kg body weight, respectively for 28 days. On day 21 the external surface of right ear pinna of rats were sensitized to 40 µl of 2% Dinitroflurobenzene in vehicle followed by challenge application of 40 µl of 1% Dinitroflurobenzene in vehicle on day 25. The left ear pinna served as control and 40 µl of vehicle (4:1 acetone-olive oil) was applied. The increase in ear thickness (in mm) was measured with Engineers micrometer at 0, 6, 12, 24 and 48 h post challenge. The results revealed a dose dependent decrease (p < 0.001) in mean ear thickness (in mm) of sodium fluoride intoxicated rats following challenge application of 1% Dinitroflurobenzene in vehicle. The blood picture revealed dose dependent leucocytosis associated with neutrophilia and lymphocytopaenia. There was also dose dependent decrease in organosomatic index of spleen and severe depletion of lymphocytes in white pulp of spleen. This report highlights the proposition that prolonged exposure to fluoride contaminated drinking water is likely to result in immunotoxicity.

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Effects of fluoride and mercury on human cytokine response in vitro*1

Cited by 3 publications

References 0 publications

Effect of Fluoride on Endocytosis and Surface Marker Expression Levels of Mouse B Cells In Vitro

Effect of Fluoride on Endocytosis and Surface Marker Expression Levels of Mouse B Cells In Vitro

Mercury and metabolic syndrome: a review of experimental and clinical observations

Immunotoxic potential of sodium fluoride following subacute exposure in Wistar rats

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