Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis

Sarma, Jogesh; Marshall, Bryan E.; Cleeve, V.; Tate, David F.; Oswald, T; Woolfrey, Steven G.

doi:10.1016/j.jhin.2015.05.006

Cited by 40 publications

(31 citation statements)

References 13 publications

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“…Two teams chose to concurrently restrict cephalosporins and fluoroquinolones. Sarma et al used ciprofloxacin resistance as an indicator, and showed a decrease in levels of ciprofloxacin-resistant ESBLs as well as statistical correlation between ciprofloxacin use and ciprofloxacin-resistant Enterobacteriaceae [29]. This is in line with the results by Aldeyab [17] and O'Brien et al [18] regarding solitary fluoroquinolone restriction.…”

Section: Multiple Restrictionssupporting

confidence: 52%

Role of antimicrobial restrictions in bacterial resistance control: a systematic literature review

Chatzopoulou

Reynolds

2020

Journal of Hospital Infection

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Section: Multiple Restrictionssupporting

confidence: 52%

Role of antimicrobial restrictions in bacterial resistance control: a systematic literature review

Chatzopoulou

Reynolds

2020

Journal of Hospital Infection

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“…Some studies have named the consumption of quinolones as a risk factor for the development of ESBLs. 22,23 Otherhave demonstrated an association similar to the present work and have suggested that the presence of ESBLs is a risk factor for the resistance to FQs, even though ESBLs are not directly related to resistance to FQ's. 6,24 Future studies of molecular mechanisms of resistance will be important because it is possible that a plasmid is present that encodes ESBL enzymes (bla ESBL ) and FQ's resistance determinants (qnr; aac (6') -Ib -cr; qepA).…”

Section: R Epidemiol Control Infec Santa Cruz Do Sulsupporting

confidence: 86%

Factors associated with ciprofloxacin and levofloxacin resistance in gram-negative bacilli isolated from urinary tract infections

Volcão

Lacava

Ramis

et al. 2016

Rev Epidemiol Control Infect

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Exceto onde especificado diferentemente, a matéria publicada neste periódico é licenciada sob forma de uma licença Creative Commons -Atribuição 4. //dx.doi.org/10.17058/reci.v6i1.6574 ARTIGO ORIGINAL Fatores associados com a resistência a ciprofloxacina e levofloxacina em bacilos Gram-negativos isolados de infecções do trato urinárioFactors associated with resistance to ciprofloxacin and levofloxacin in Gram-negative isolates from urinary tract infections Foram analisadas variáveis independentes como idade, sexo, origem da infecção e características dos isolados clínicos bacterianos. Resultados: Dos 562 BGN isolados e analisados, foi encontrado uma frequência de resistência à ciprofloxacina e à levofloxacina de 25,5 e 23,3%, respectivamente, 62,6% de origem comunitária e 59% de origem hospitalar. Os fatores de risco associados à resistência a ciprofloxacina e levofloxacina, foram pacientes do gênero masculino, infecções adquiridas no ambiente hospitalar, com maior tempo de internação, e a presença de β-lactamases de espectro estendido (ESBL) nos isolados clínicos. Conclusões: Os resultados mostraram uma forte associação da resistência bacteriana de BGN com a permanência no ambiente hospitalar e a presença de ESBL. A fim de controlar a resistência antimicrobiana e a redução nos custos em saúde pública torna-se necessário que os hospitais tenham uma forte política de vigilância contínua do uso e da resistência de antibióticos. Background and Objectives:Fluoroquinolones represent a class of antimicrobial agents that is often prescribed to treat urinary tract infections (UTI), both nosocomial ones and those originating in the community. This study aims to determine the frequency of resistance to ciprofloxacin and levofloxacin and its associated factors in Gram-negative bacilli (GNB) isolated from patients with urinary tract infection in a hospital in southern The resistance rate to ciprofloxacin and levofloxacin was 25.5 and 23.3%, respectively in the 562 BGN isolates analytical study of cases of UTI in patients treated at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande, Rio Grande do Sul between August 2012 and July 2013. The study used the following inclusion criteria: patients with a GNB urinary tract infection from whom samples were obtained and tested for susceptibility toFQ's. Patients were excluded if samples of their infections were not obtained or if there was a lack of sample data. ABSTRACT Microbiological analysisThe bacterial identification, assessment of susceptibility to ciprofloxacin and levofloxacin, and identification of extended-spectrum β-lactamases (ESBL) were performed using the Phoenix BD TM Diagnostic System following the manufacturer's standards. Urine samples were sent to the Analyzes Clinics Laboratory of HU-FURG and were plated on blood agar (or CLED agar when blood agar was not available) and MacConkey agar. After the incubation period (35° C for 18 to 24 hours), the colonies were quantified to determine if a UTI was present, and biochemical methods were used to c...

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“…Not surprisingly, the most important risk factor for FQR E. coli appears to be previous FQs use [22][23][24]. Restriction of quinolone use can offer opportunities to reduce the prevalence of FQR E. coli [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014

et al. 2020

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Background: The purpose of the study is to discuss the correlation between the resistance rate of gram negative bacteria to fluoroquinolones (FQ) and antibiotic consumption intensity of 145 China tertiary hospitals in 2014. Methods: This retrospective study adopted national monitoring data from 2014. Each participating hospital required to report annual consumption of each antibiotic, and the resistance rate of gram negative bacteria to FQ. Then the correlation between antibiotic usage and fluoroquinolones-resistant (FQR) rate was consequently investigated. Results: One hundred forty-five hospitals were included in the study, and the median antibiotic consumption intensity was 46.30 (23.93-115.39) defined daily dosages (DDDs) per 100 patient-days. Cephalosporins ranks first in the antibiotics consumption, followed by fluoroquinolones, penicillins, and carbapenems. Fluoroquinolones resistance rate varied from hospital to hospital. The correlation analysis showed significant relationship between the percentage of FQR Escherichia coli and the consumption of FQs (r = 0.308, p<0.01) and levofloxacin (r = 0.252, p<0.01). For FQR Klebsiella pneumoniae, not only FQs (r = 0.291, p<0.01) and levofloxacin (r = 0.260, p<0.01) use but also carbapenems (r = 0.242, p<0.01) and overall antibiotics (r = 0.247, p<0.01) use showed significant correlation. The resistant proportion of FQR Pseudomonas aeruginosa was observed to be correlated with the consumption of all antibiotics (r = 0.260, p<0.01), FQs (r = 0.319, p<0.01) and levofloxacin (r = 0.377, p<0.01). The percentage of levofloxacin-resistant Acinetobacter baumannii was significantly correlated with the consumption of all antibiotics (r = 0.282, p<0.01), third-generation cephalosporins excluding combinations with beta-lactamase inhibitors (r = 0.246, p<0.01), FQs (r = 0.254, p<0.01) and levofloxacin (r = 0.336, p<0.01). However, the correlation of the ciprofloxacin-resistant A. baumannii and the antibiotics consumption was not found.

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Effects of fluoroquinolone restriction (from 2007 to 2012) on resistance in Enterobacteriaceae: interrupted time-series analysis

Cited by 40 publications

References 13 publications

Role of antimicrobial restrictions in bacterial resistance control: a systematic literature review

Role of antimicrobial restrictions in bacterial resistance control: a systematic literature review

Factors associated with ciprofloxacin and levofloxacin resistance in gram-negative bacilli isolated from urinary tract infections

Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014

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