Effects of fluoxetine on the immunosuppressive response to stress in mice

Freire‐Garabal, Manuel; Núñez, M. R.; Losada, C.; Pereiro, D.; Riveiro, María P.; González-Patiño, Ezequiel; Mayán, JoséM.; Rey-Méndez, Manuel

doi:10.1016/s0024-3205(97)00329-9

Cited by 29 publications

(15 citation statements)

References 44 publications

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“…No entanto, o mesmo estudo mostrou que, quando tratados com fluoxetina, esses animais conseguiram restabelecer os valores iniciais de linfócitos TCD4+. Segundo Freire-Garabal et al (1997) os camundongos estressados e tratados com fluoxetina apresentaram maior quantidade de linfócitos circulantes que os seus respectivos controles (estressados e não tratados com fluoxetina).…”

Section: Discussionunclassified

Efeitos comportamentais e imunológicos da fluoxetina em ratos submetidos ao nado forçado

Fernandes

Ramos

Estanislau

et al. 2012

Psic.: Teor. e Pesq.

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RESUMO -No presente trabalho, os efeitos comportamentais e imunomoduladores da fluoxetina foram avaliados num modelo animal de depressão, o nado forçado. Nesse, o comportamento de flutuar é sensível a antidepressivos e é usado como índice de desespero comportamental. Foram utilizados dois grupos experimentais, sendo um grupo controle tratado com salina e outro grupo teste tratado com a fluoxetina, ambos administrados por via intra-peritoneal. Os animais foram tratados três vezes ao dia por 12 dias. Adicionalmente, a resposta imune humoral a uma imunoestimulação (hemácias de carneiro) foi avaliada. A fluoxetina provocou aumento no tempo em flutuação, queda na massa corporal e menor produção total de anticorpos. Os resultados indicam uma modulação simultânea do comportamento e do sistema imunológico pela fluoxetina.Palavras-chave: imunomodulação, massa corporal, nado forçado, fluoxetina. Behavioral and Immunological Effects of Fluoxetine in Rats Submitted to Forced SwimmingABSTRACT -In the present study, behavioral and immunomodulatory effects of fluoxetine were evaluated with the forced swim test, an animal model of depression. In this model, floating behavior is responsive to antidepressants and is used as a behavioral index of despair. During 12 days, three times a day, two groups were treated intraperitoneally with saline or fluoxetine. Additionally, the humoral immune response to immunostimulation (sheep red blood cells) was evaluated. The animals treated with fluoxetine floated longer, showed decreases in body mass and had lower total production of antibodies.The results indicate simultaneous modulation of behavior and antibody production by fluoxetine.

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Section: Discussionunclassified

Efeitos comportamentais e imunológicos da fluoxetina em ratos submetidos ao nado forçado

Fernandes

Ramos

Estanislau

et al. 2012

Psic.: Teor. e Pesq.

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“…Frick et al (2009) observed that chronic restraint stress in rats causes decreases in CD4 + T lymphocytes and no change in CD8 + T lymphocyte but when treated with fluoxetine, initial values of CD4 + T cells were restored. According to Freire-Garabal et al (1997), stressed rats treated with fluoxetine had a higher number of circulating lymphocytes than their control counterparts (stressed and not treated with fluoxetine).…”

Section: Discussionmentioning

confidence: 99%

“…Garabal-Freire et al (1997) submitted mice to a sound stressor (100 dB, 1 to 3 hours per day, four to twelve days) and observed a decrease in the number of thymic and spleen cells; this stressor also contributed to a reduction in relative thymus weight, a condition reversed by treatment with fluoxetine (5 mg/kg). Kubera et al (2006) treated rats with three doses of imipramine 1, 5 and 24 hours before forced swimming and found that acute treatment with this drug did not alter the relative thymus weight, but did reduce spleen weight.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Fernandes¹,

Venâncio²,

Estanislau³

2012

Effects of Antidepressants

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“…On the other hand, treatment with fluoxetine, a nontricyclic antidepressant drug, was found to attenuate some effects of stress on the immune systems of rodents, such as T-cell depletion, the inhibition of the blastogenic (15) and cytotoxic activities of spleen cells (34), and defects in phagocytosis (17).…”

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confidence: 99%

Effects of Psychological Stress and Fluoxetine on Development of Oral Candidiasis in Rats

Núñez¹,

Novío²,

Suárez³

et al. 2010

Clin Vaccine Immunol

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Psychological stress has been found to suppress cell-mediated immune responses that are important for limiting the proliferation of Candida albicans. Fluoxetine has been observed to reduce negative consequences of stress on the immune system in experimental and clinical models, but there are no data on its effects on oral candidiasis. We designed experiments to evaluate the effects of fluoxetine on the development of oral candidiasis in Sprague-Dawley rats exposed to a chronic auditory stressor. Animals were submitted to surgical hyposalivation in order to facilitate the establishment and persistence of C. albicans infection. Stress application and treatment with drugs (placebo or fluoxetine) were initiated 7 days before C. albicans inoculation and lasted until the end of the experiments, on day 15 postinoculation. Establishment of C. albicans infection was evaluated on days 2 and 15 after inoculation. Tissue injury was determined by the quantification of the number and type (normal or abnormal) of papillae on the dorsal tongue per microscopic field. A semiquantitative scale was devised to assess the degree of colonization of the epithelium by fungal hyphae. Our results showed that stress exacerbates C. albicans infection in the tongues of rats. Significant increases in Candida counts, the percentage of the tongue's surface covered with clinical lesions, the percentage of abnormal papillae, and the colonization of the epithelium by hyphae were found in stressed rats compared to the nonstressed ones. Treatment with fluoxetine significantly reversed these adverse effects of stress. Besides the psychopharmacological properties of fluoxetine against stress, it has consequences for Candida infection.

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Effects of fluoxetine on the immunosuppressive response to stress in mice

Cited by 29 publications

References 44 publications

Efeitos comportamentais e imunológicos da fluoxetina em ratos submetidos ao nado forçado

Efeitos comportamentais e imunológicos da fluoxetina em ratos submetidos ao nado forçado

Evaluation of the Humoral Immune Response of Wistar Rats Submitted to Forced Swimming and Treated with Fluoxetine

Effects of Psychological Stress and Fluoxetine on Development of Oral Candidiasis in Rats

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