Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life

Edin, Heather M.; Andersen, Leslie; Schoaf, Lynne; Scott-Wilson, Catherine; Ho, Shuyen; Ortega, Héctor

doi:10.1016/s1081-1206(10)60338-9

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…Heterogeneity was high for the comparison of FP/Sal versus placebo (I 2 88.6%, τ 0.3), which was the result of a single outlier study [58]. When this study was omitted from the analysis, heterogeneity was reduced (I 2 36.5%, τ 0.07), with results that were consistent with the base case: MD 0.…”

Section: Change From Baseline In Aqlqmentioning

confidence: 84%

“…The database searches yielded 1109 unique publications and six records were identified through other sources (Figure 1). Overall, 27 publications that described the results from 19 unique studies [37,38,[49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68] were included in the SLR, of which 15 studies [37,38, 49,50,52-55, 57-62, 55-68] were deemed suitable for inclusion in the base case NMA (Table 2).…”

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

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Impact of inhaled fluticasone propionate/salmeterol on health-related quality of life in asthma: A network meta-analysis

Maneechotesuwan¹,

Singh²,

Fritscher³

et al. 2022

Respiratory Medicine

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Section: Change From Baseline In Aqlqmentioning

confidence: 84%

Section: Search Results and Study Characteristicsmentioning

confidence: 99%

Impact of inhaled fluticasone propionate/salmeterol on health-related quality of life in asthma: A network meta-analysis

Maneechotesuwan¹,

Singh²,

Fritscher³

et al. 2022

Respiratory Medicine

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“…According to the literature, compounds 1 – 9 and their respective derivatives show anticancer [ 11 , 12 , 13 ], antibacterial [ 14 ], antifungal [ 15 ], and anti-inflammatory [ 13 , 15 , 16 ] activities. Some of them are widely used in therapy as the registered drugs: flumethasone [ 17 ], fluticasone propionate [ 18 ], and capecitabine [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Thiol Derivatives of Biological Active Compounds for Nanotechnology Application

et al. 2020

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An efficient method of thiol group introduction to the structure of common natural products and synthetic active compounds with recognized biological efficacy such genistein (1), 5,11-dimethyl-5H-indolo[2,3-b]quinolin (2), capecitabine (3), diosgenin (4), tigogenin (5), flumethasone (6), fluticasone propionate (7), ursolic acid methyl ester (8), and β-sitosterol (9) was developed. In most cases, the desired compounds were obtained easily via two-step processes involving esterification reaction employing S-trityl protected thioacetic acid and the corresponding hydoxy-derivative, followed by removal of the trityl-protecting group to obtain the final compounds. The results of our preliminary experiments forced us to change the strategy in the case of genistein (1), and the derivatization of diosgenin (4), tigogenin (5), and capecitabine (3) resulted in obtaining different compounds from those designed. Nevertheless, in all above cases we were able to obtain thiol-containing derivatives of selected biological active compounds. Moreover, a modelling study for the two-step thiolation of genistein and some of its derivatives was accomplished using the density functional theory (B3LP). A hypothesis on a possible reason for the unsuccessful deprotection of the thiolated genistein is also presented based on the semiempirical (PM7) calculations. The developed methodology gives access to new sulphur derivatives, which might find a potential therapeutic benefit.

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Comparing the efficacy and safety of salmeterol/fluticasone pMDI versus its mono-components, other LABA/ICS pMDIs and salmeterol/fluticasone Diskus in patients with asthma

Mehta

Aggarwal

Gogtay

et al. 2014

Expert Opinion on Drug Delivery

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pMDIs play an important role in inhalation therapy given the low price, low maintenance and convenience of use. LABA/ICS combinations are the preferred choice of medication for asthma treatment and will remain the mainstay for the decades to come. In our opinion, pMDI should be the choice of device to administer LABA/ICS maintenance therapy, as it is already being used by the patients for reliever therapy, which may eventually improve patient adherence and compliance.

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Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life

Cited by 4 publications

References 19 publications

Impact of inhaled fluticasone propionate/salmeterol on health-related quality of life in asthma: A network meta-analysis

Impact of inhaled fluticasone propionate/salmeterol on health-related quality of life in asthma: A network meta-analysis

Synthesis of Thiol Derivatives of Biological Active Compounds for Nanotechnology Application

Comparing the efficacy and safety of salmeterol/fluticasone pMDI versus its mono-components, other LABA/ICS pMDIs and salmeterol/fluticasone Diskus in patients with asthma

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