Effects of Fluvoxamine Treatment on the in Vivo Binding of [F-18]FESP in Drug Naive Depressed Patients: A Pet Study

Moresco, Rosa María; Colombo, Cristina; Fazio, Ferruccio; Bonfanti, A.; Lucignani, Giovanni; Messa, Cristina; Gobbo, C.; Galli, Laura; Sole, Angelo Del; Lucca, A.; Smeraldi, Enrico

doi:10.1006/nimg.2000.0619

Cited by 42 publications

(18 citation statements)

References 72 publications

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“…The serotoninergic system, particularly 5-HT 2A receptors, is involved in the control of normal and pathological behaviors. 51 A diffuse reduction in 5-HT 2A receptor densities was reported in the dorsolateral frontal cortex of patients with unipolar major depression, extending to the temporal and occipital cortices. 52,53 Thus, this in vivo evidence in fv-FTLD of 5-HT 2A receptor depletion in selected frontal medial and midbrain areas, in contrast with those previously observed in unipolar major depression, might represent another biological marker of the disease.…”

Section: [ 11 C]mdl100907 Positron Emission Tomography Resultsmentioning

confidence: 98%

Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration

Franceschi

Anchisi

Pelati

et al. 2005

Annals of Neurology

161

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In patients with the frontal variant of frontotemporal lobar degeneration (fv-FTLD), behavioral abnormalities may vary from apathy with motor slowness (apathetic form) to disinhibition with agitation (disinhibited form). These clinical presentations may be related to specific regional cerebral dysfunction and to deficit in the serotoninergic system. We studied cerebral glucose uptake using (18)F-fluorodeoxyglucose and positron emission tomography in 18 patients fulfilling clinical criteria for fv-FTLD and showing, respectively, an apathetic or disinhibited behavioral syndrome. In eight of these patients, we also evaluated the 5-hydroxytryptamine-2A receptor cerebral receptor distribution with [(11)C]MDL and positron emission tomography. We found a reduction of frontal glucose metabolism in the whole group of fv-FTLD patients. Apathetic syndrome was associated with a prevalent dorsolateral and frontal medial hypometabolism, whereas the disinhibited syndrome demonstrated a selective hypometabolism in interconnected limbic structures (the cingulate cortex, hippocampus/amygdala, and accumbens nucleus). The in vivo measurements of [(11)C]MDL indicated a significant reduction of 5-hydroxytryptamine-2A receptors in orbitofrontal, frontal medial, and cingulate cortices. These (18)F-fluorodeoxyglucose positron emission tomography changes can be considered as specific functional markers of the different behavioral presentations in fv-FTLD. The serotoninergic system dysfunction provides a rationale for therapeutic trials with selective serotonin reuptake inhibitors.

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Section: [ 11 C]mdl100907 Positron Emission Tomography Resultsmentioning

confidence: 98%

Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration

Franceschi

Anchisi

Pelati

et al. 2005

Annals of Neurology

161

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“…Other reports also primarily show nonsignificant differences in 5-HT 2A receptor ligand binding between controls and depressed patients (Attar-Levy et al, 1999;Meyer et al, 1999;Meltzer et al, 1999). Some studies have found decreased 5-HT 2A receptor binding in depressed patients more diffusely (Larisch et al, 2001;Yatham et al, 2000;Moresco et al, 2000). Biver et al (1997b) found decreased 5-HT 2A receptor binding in a single region of the frontal cortex.…”

Section: Discussionmentioning

confidence: 97%

“…In a sample of seven young adult benzodiazepine-treated patients, Attar-Levy et al (1999) found significant decreases in frontal 5-HT 2A receptors determined with [ 18 F]setoperone but no differences in temporal, parietal, or occipital receptors. Using spiperone, Moresco et al (2000) found significant differences in 15 antidepressant-free depressed subjects in frontal, temporal, and occipital cortex but not in the anterior cingulate. Biver et al (1997b) found significant reduction in orbito-frontal and insular 5-HT 2A receptors in eight depressed antidepressant-free subjects using [ 18 F]altanserin, a ligand with virtually no affinity for dopamine.…”

Section: Introductionmentioning

confidence: 86%

Decreased Hippocampal 5-HT2A Receptor Binding in Older Depressed Patients Using [18F]Altanserin Positron Emission Tomography

Sheline

Mintun

Deanna

et al. 2004

Neuropsychopharmacol

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Serotonin receptor changes have been associated with the pathophysiology and treatment of major depression. Only one other study has investigated serotonin receptor changes in older depressed patients. We used positron emission tomography (PET) and [ 18 F]altanserin, a ligand with high affinity for the 5-HT 2A receptor, to examine the relationship between 5-HT 2A receptor density and depression. Depressed subjects (n ¼ 16), age450 years, were recruited as part of a larger study. Older depressed subjects consisted of early-onset recurrent depression (EORD, n ¼ 11) and late-onset depression (LOD, n ¼ 5). An age-matched control group (n ¼ 9) was also recruited. All subjects were right-handed, nonsmokers and antidepressant-free. Regions of interest were determined on a summed MPRAGE scan transformed into Talairach space and coregistered with the PET images. Depressed subjects had less hippocampal 5-HT 2A receptor binding than controls (p ¼ 0.05). No significant differences in receptor binding were found between EORD and LOD subjects. Depressed subjects not previously treated for depression (n ¼ 6) had less hippocampal 5-HT 2A receptor binding (p ¼ 0.04) than previously treated subjects (n ¼ 10). It may be that prior medication treatment provides a compensatory upregulation of the 5-HT 2A receptor.

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“…Numerous studies have linked observed neural processing characteristics from fMRI and PET with disease development or with clinical responses to treatment [84,85,86,87,88]. For example, several authors have established associations between treatment response and preto post-treatment changes in measured brain activity [89,90,91,92,93,94,95].…”

Section: Statistical Prediction Techniquesmentioning

confidence: 99%

Statistical Approaches to Functional Neuroimaging Data

Bowman

Guo

Derado

2007

Neuroimaging Clinics of North America

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SynopsisThe field of statistics makes valuable contributions to functional neuroimaging research by establishing procedures for the design and conduct of neuroimaging experiements and by providing tools for objectively quantifying and measuring the strength of scientific evidence provided by the data. Two common functional neuroimaging research objecitves include detecting brain regions that reveal task-related alterations in measured brain activity (activations) and identifying highly correlated brain regions that exhibit similar patterns of activity over time (functional connectivity). In this article, we highlight various statistical procedures for analyzing data from activation studies and from functional connectivity studies, focusing on functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) data. We also discuss emerging statistical methods for prediction using fMRI and PET data, which stand to increase the translational significance of functional neuroimaging data to clinical practice.

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Effects of Fluvoxamine Treatment on the in Vivo Binding of [F-18]FESP in Drug Naive Depressed Patients: A Pet Study

Cited by 42 publications

References 72 publications

Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration

Glucose metabolism and serotonin receptors in the frontotemporal lobe degeneration

Decreased Hippocampal 5-HT2A Receptor Binding in Older Depressed Patients Using [18F]Altanserin Positron Emission Tomography

Statistical Approaches to Functional Neuroimaging Data

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