Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study

Zhan, Wenbo

doi:10.3390/pharmaceutics12010069

Cited by 9 publications

(10 citation statements)

References 77 publications

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“…Drug transvascular permeation upon BBBD Zhan, 2020) 3D geometry of a brain tumor. A schematic of the drug transport with the compartmental modeling of such a system is shown in Figure 10a.…”

Section: Properties Equations Parameters Referencesmentioning

confidence: 99%

Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling

Kashkooli

Hornsby

Kolios

et al. 2023

WIREs Nanomed Nanobiotechnol

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Computational modeling enables researchers to study and understand various complex biological phenomena in anticancer drug delivery systems (DDSs), especially nano‐sized DDSs (NSDDSs). The combination of NSDDSs and therapeutic ultrasound (TUS), that is, focused ultrasound and low‐intensity pulsed ultrasound, has made significant progress in recent years, opening many opportunities for cancer treatment. Multiple parameters require tuning and optimization to develop effective DDSs, such as NSDDSs, in which mathematical modeling can prove advantageous. In silico computational modeling of ultrasound‐responsive DDS typically involves a complex framework of acoustic interactions, heat transfer, drug release from nanoparticles, fluid flow, mass transport, and pharmacodynamic governing equations. Owing to the rapid development of computational tools, modeling the different phenomena in multi‐scale complex problems involved in drug delivery to tumors has become possible. In the present study, we present an in‐depth review of recent advances in the mathematical modeling of TUS‐mediated DDSs for cancer treatment. A detailed discussion is also provided on applying these computational models to improve the clinical translation for applications in cancer treatment.This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Section: Properties Equations Parameters Referencesmentioning

confidence: 99%

Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling

Kashkooli

Hornsby

Kolios

et al. 2023

WIREs Nanomed Nanobiotechnol

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“…BBs not only impede treatment options but diminish bioavailability of drugs in regions protected by BBs, which can lead to increased drug resistance in bacteria and other pathogens. Moreover, engineered nanoparticles and drug therapies for crossing BBs could potentially dysregulate or suppress biochemical pathways and increase risks of side effects [ 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

2021

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Since the 2013 Nobel Prize was awarded for the discovery of vesicle trafficking, a subgroup of nanovesicles called exosomes has been driving the research field to a new regime for understanding cellular communication. This exosome-dominated traffic control system has increased understanding of many diseases, including cancer metastasis, diabetes, and HIV. In addition to the important diagnostic role, exosomes are particularly attractive for drug delivery, due to their distinctive properties in cellular information transfer and uptake. Compared to viral and non-viral synthetic systems, the natural, cell-derived exosomes exhibit intrinsic payload and bioavailability. Most importantly, exosomes easily cross biological barriers, obstacles that continue to challenge other drug delivery nanoparticle systems. Recent emerging studies have shown numerous critical roles of exosomes in many biological barriers, including the blood–brain barrier (BBB), blood–cerebrospinal fluid barrier (BCSFB), blood–lymph barrier (BlyB), blood–air barrier (BAB), stromal barrier (SB), blood–labyrinth barrier (BLaB), blood–retinal barrier (BRB), and placental barrier (PB), which opens exciting new possibilities for using exosomes as the delivery platform. However, the systematic reviews summarizing such discoveries are still limited. This review covers state-of-the-art exosome research on crossing several important biological barriers with a focus on the current, accepted models used to explain the mechanisms of barrier crossing, including tight junctions. The potential to design and engineer exosomes to enhance delivery efficacy, leading to future applications in precision medicine and immunotherapy, is discussed.

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“…In addition, since the required acoustic energy and response differ depending on the size and concentration of microbubbles, the physical parameters of ultrasound, such as period per pulse, pulse amplitude, pulse repetition frequency, and exposure length, must be adjusted to determine the optimal ultrasound and microbubble combination [ 44 , 45 ]. These phenomena induce biological changes in the BBB, such as increased endocytosis/transcytosis, paracellular passage, and opening of the tight junctions, thus increasing the permeability of the BBB macrostructure for brain cancer therapy [ 17 , 46 , 47 , 48 , 49 ]. This review investigated the generation methods, constituent materials, and various studies on MBs for brain cancer treatment ( Scheme 1 ).…”

Section: Introductionmentioning

confidence: 99%

Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers

2023

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The blood-brain barrier (BBB) is one of the most selective endothelial barriers that protect the brain and maintains homeostasis in neural microenvironments. This barrier restricts the passage of molecules into the brain, except for gaseous or extremely small hydrophobic molecules. Thus, the BBB hinders the delivery of drugs with large molecular weights for the treatment of brain cancers. Various methods have been used to deliver drugs to the brain by circumventing the BBB; however, they have limitations such as drug diversity and low delivery efficiency. To overcome this challenge, microbubbles (MBs)-based drug delivery systems have garnered a lot of interest in recent years. MBs are widely used as contrast agents and are recently being researched as a vehicle for delivering drugs, proteins, and gene complexes. The MBs are 1–10 μm in size and consist of a gas core and an organic shell, which cause physical changes, such as bubble expansion, contraction, vibration, and collapse, in response to ultrasound. The physical changes in the MBs and the resulting energy lead to biological changes in the BBB and cause the drug to penetrate it, thus enhancing the therapeutic effect. Particularly, this review describes a state-of-the-art strategy for fabricating MB-based delivery platforms and their use with ultrasound in brain cancer therapy.

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Effects of Focused-Ultrasound-and-Microbubble-Induced Blood-Brain Barrier Disruption on Drug Transport under Liposome-Mediated Delivery in Brain Tumour: A Pilot Numerical Simulation Study

Cited by 9 publications

References 77 publications

Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling

Ultrasound‐mediated nano‐sized drug delivery systems for cancer treatment: Multi‐scale and multi‐physics computational modeling

Unlocking the Power of Exosomes for Crossing Biological Barriers in Drug Delivery

Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers

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