Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial

Kim, Young–In; Baik, Hyun Wook; Fawaz, Khaled; Knox, Tamsin A.; Lee, Young Mee; Norton, Richard A.; Libby, Eric; Mason, Joel B.

doi:10.1111/j.1572-0241.2001.03474.x

Cited by 115 publications

(54 citation statements)

References 56 publications

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“…This is in contrast with an earlier study that observed a decrease of 35% with a 5 mg day À1 folic acid supplementation (Kim et al, 2001). Our participants, at baseline however, had no evidence of folate deficiency and, in fact, had generally higher concentrations of folate compared to earlier studies (Selhub et al, 1993(Selhub et al, , 1999.…”

Section: B-vitamin Deficiencycontrasting

confidence: 99%

“…Five of the participants, all in the treatment group, reported increased constipation (P ¼ 0.056). (Kim et al, 2001). Thiamin was assessed at the time of entry to the study by the Reference Laboratory, St Joseph's Hospital, London, Ontario, Canada.…”

Section: Study Protocolmentioning

confidence: 99%

“…The dosages used were based on problem-free usage in previous clinical trials (e.g. Baron et al, 1999, Bonithon-Kopp et al, 2000Stark et al, 2000;Kim et al, 2001). The period of intervention (28 days) was chosen so as to allow sufficient time for biochemical measures representing the major environmental exposures to stabilise.…”

Section: Intervention Agentsmentioning

confidence: 99%

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A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation

Cirocco

Giacca

et al. 2005

Br J Cancer

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Colorectal cancer risk is associated with biochemical markers for B-vitamin deficiency, insulin resistance and colonic inflammation, suggesting that these three conditions are each involved in colon carcinogenesis. We expected that dietary supplements of folic acid, n-3 fatty acids and calcium would reduce the markers and thus possibly cancer risk. We therefore randomised 98 participants, with previous colonic polyps or intramucosal carcinomas, to a combined treatment of supplementary folic acid, fish oil and calcium carbonate, or placebos for 28 days. Blood and faecal samples were obtained prior to and at the conclusion of the intervention and analysed for plasma folate, homocysteine, insulin, free fatty acids, triglycerides and faecal calprotectin. In addition, plasma vitamin B 12 , thiamin, glucose and C-reactive protein were assessed. Our supplemental strategy modestly affected some of the biomarkers associated with folate metabolism and insulin resistance, but had no effect on those associated with colonic inflammation. This pilot study demonstrates the feasibility and practicality of clinical trials aimed at reducing diet-related biochemical risk markers for colon cancer. We suggest that long-term intervention studies with tumour-related end points should be undertaken when the intervention agents used are found effective in short-term biochemical risk marker trials.

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Section: B-vitamin Deficiencycontrasting

confidence: 99%

Section: Study Protocolmentioning

confidence: 99%

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A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation

Cirocco

Giacca

et al. 2005

Br J Cancer

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“…Cravo et al 53,54 observed that folate supplementation significantly reversed genomic DNA hypomethylation of the colonic mucosa. Kim et al 55 reported that DNA methylation underwent improvement with folate supplementation. However, methylation also improved with a placebo, which might have been caused by participants who were informed about the possible cancer-protective effects of folate.…”

Section: Discussionmentioning

confidence: 99%

Intake of dietary folate vitamers and risk of colorectal carcinoma

Konings

Goldbohm

Brants

et al. 2002

Cancer

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BACKGROUNDSeveral studies have reported inverse associations between folate intake and colorectal carcinoma risk. Few were prospective studies and none evaluated the association between the intake of individual folate vitamers and colorectal carcinoma risk.METHODSThe aim of the current study was to investigate the relationship between dietary folate intake and the risk of colorectal carcinoma in a large prospective cohort study in The Netherlands comprising 120,852 men and women aged 55–69 years. After 7.3 years of follow‐up, 760 colon and 411 rectal carcinoma cases were available for analysis. Data processing and analysis used the case–cohort approach. A new Dutch database was used to estimate intakes of total and individual folate vitamers.RESULTSAnalyses adjusted for age, energy intake, family history of colorectal carcinoma, alcohol, vitamin C, iron, and dietary fiber intake yielded an inverse association between colon carcinoma risk and total dietary folate intake (rate ratio [RR]highest vs. lowest quintile, men: 0.73; 95% confidence interval [CI], 0.46–1.17, P trend = 0.03; women: 0.68; 95% CI, 0.39–1.20, P trend = 0.18). An inverse association between rectal carcinoma and total dietary folate intake was found only among men (RR highest vs. lowest quintile, men: 0.66; 95% CI, 0.35–1.21, P trend = 0.03). Analyses showed no clear difference in colorectal carcinoma risk associated with intake of different folate vitamers.CONCLUSIONSDietary folate intake was related inversely to colon and male rectal carcinoma risk. Cancer 2002;95:1421–33. © 2002 American Cancer Society.DOI 10.1002/cncr.10866

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“…Low dietary FA intake also results in an interruption of the DNA repair capability (Wei et al, 2003). The majority of prospective and case-controlled studies showed that low levels of serum FA, red cell FA concentration and low dietary FA intake are inversely correlated with colon cancer, breast cancer, adenoma and other cancers at several sites (Kim et al, 2001;Wang et al, 2006;Lin et al, 2010;Johnson et al, 2011).…”

Section: Interactions Between Mthfr C677t -A1298c Variants and Folic mentioning

confidence: 99%

Interactions Between MTHFR C677T - A1298C Variants and Folic Acid Deficiency Affect Breast Cancer Risk in a Chinese Population

Ni²,

Xu³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Effects of folate supplementation on two provisional molecular markers of colon cancer: a prospective, randomized trial

Cited by 115 publications

References 56 publications

A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation

A pilot randomised controlled trial to reduce colorectal cancer risk markers associated with B-vitamin deficiency, insulin resistance and colonic inflammation

Intake of dietary folate vitamers and risk of colorectal carcinoma

Interactions Between MTHFR C677T - A1298C Variants and Folic Acid Deficiency Affect Breast Cancer Risk in a Chinese Population

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