Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight and obese women: a randomized double-blind placebo-controlled trial

Influence of High-Protein Food on Physical Function of Athletes

“…is classification method intuitively expresses the importance of coordination, strength, endurance, agility, speed, flexibility, and other qualities in physical fitness [10]. Similarly, Sabihi et al also believed that physical fitness refers to the athletic ability of an athlete's body, which is an important part of competitive ability and a synthesis of various physical athletic abilities necessary for athletes to improve their technical and tactical levels and create excellent results [11].…”

Insulin-like growth factor-1 signaling in the tumor microenvironment: Carcinogenesis, cancer drug resistance, and therapeutic potential

“…Furthermore, available data suggest a key role for IGFs both as a link between insulin resistance syndrome and cancer, and as a driver of cancer drug resistance associated with metabolic syndrome. For instance, both diabetic and non-diabetic women with insulin resistance have higher risk to develop breast, endometrial and ovarian cancer, and results from studies in ovarian and cervical cancer suggest that the first-line type 2 diabetes drug and anti-insulin resistance agent metformin is a good candidate in combination therapies for these cancers ( 4 , 9 ). Studies have shown that metformin has antitumor activity in the major gynecologic malignancies through a pleiotropic mechanism involving direct silencing of IGF-1R signaling and indirect silencing of this signaling pathway by targeting its downstream targets, including MAPK and mTOR ( 21 , 22 ).…”

“…According to emerging evidence from molecular studies, the tumor microenvironment uses key paracrine factors such as insulin-like growth factor 1 (IGF-1) to fuel tumorigenesis (1)(2)(3). Certainly, in the current global obesity epidemic, IGFs have attracted attention for their potential role as a link between cancer and insulin resistance syndrome (4)(5)(6), a metabolic syndrome of increasing incidence that encompasses hyper/ hypoinsulinemia, hyper/hypoglycemia, dyslipidemia and hypertension, with a marked increase in risk to develop diabetes mellitus, cardiovascular diseases, and cancer (7)(8)(9)(10). Notably, recent reports show that antidiabetic drugs, such as metformin, can mediate anticancer effects partly by silencing IGF-1 expression (9,10).…”

The effects of dietary supplements in patients with cervical cancer: a comprehensive systematic review

“…Many studies confirmed that most cancer patients use complementary therapies in which dietary supplements are common [10] . For example, one study showed that long-term folate supplementation could improve metabolic status in patients with cervical intraepithelial neoplasia [11] . Recently, some studies have suggested that polymorphisms in genes related to folate metabolism might be involved in cervical neoplasia [11] , [14] , [12] , [13] .…”

“…For example, one study showed that long-term folate supplementation could improve metabolic status in patients with cervical intraepithelial neoplasia [11] . Recently, some studies have suggested that polymorphisms in genes related to folate metabolism might be involved in cervical neoplasia [11] , [14] , [12] , [13] . Folate and vitamin B12 deficiency are associated with a lower degree of long interspersed nucleotide element methylation, which might explain the risk of cervical cancer [15] .…”