Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation

Deniz, Ömür Gülsüm; Kıvrak, Elfide Gizem; Kaplan, Arife Ahsen; Altunkaynak, Berrin Zühal

doi:10.1016/j.jmau.2017.06.001

Cited by 20 publications

(9 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung cancer is the leading cause of cancer-related deaths in men and the second leading cause of cancer-related deaths in women after breast cancer in the world [ 76 ]. GLOBOCAN 2020 is an online database providing global cancer statistics and estimates of incidence and mortality in 185 countries for 36 types and all cancer sites combined.…”

Section: Cancer Status In Ethiopiamentioning

confidence: 99%

Traditional and Phytochemical Bases of Herbs, Shrubs, Climbers, and Trees from Ethiopia for Their Anticancer Response

Abate

Tadesse²,

Bachheti

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Ethiopia is one of Africa’s six plant-rich countries, with around 60% of the plants being indigenous and most of them having medicinal properties. 80% of people in the country use these plants as a primary health care system to tackle different diseases, including cancer. This review is aimed at summarizing the evidence gained from diverse MPs in Ethiopia that have been used ethnobotanically and ethnopharmacologically for treatment of cancer. The primary data sources were Google Scholar, Web of Science, Science Direct, Scopus, PubMed, and other electronic scientific databases. This literature review showed that there are around 200 MPs used as anticancer. Seventy-four herbs, 39 trees, 77 shrubs, and 17 weed/climbers belonging to 56 families have been identified for their ethnobotanical anticancer potential, and 31 species were recognized for their pharmaceutically anticancer activities. The reviewed data also indicated that many Ethiopian MPs had been used to treat breast, lung, blood, and skin cancers and other tumors. Besides, the collected data showed that the leaves (36.76%), roots (27.2%), bark (12.5%), stem (5.1%), and fruit (7.35%) of plants are commonly used for the preparation of anticancer remedies. Among the reported plant species, Euphorbiaceae (10.71%), Acanthaceae (7.14%), and Asteraceae (7.1%) are the most prominent plant families being used to treat cancer ethnobotanically. Phytochemicals such as flavonoids (like xanthone, indirubin, flavopiridol, and silybin), alkaloids (like taxol, vincristine, evodiamine, and berberine), and physalin B, D, and F steroids exhibited anticancer activity on various cancer cell lines. The crude extracts of Aerva javanica, Vernonia leopoldi, Withania somnifera, Kniphofia foliosa, and Catharanthus roseus were powerful anticancer agents with an IC50 value below 10 μg/mL. Although several Ethiopian plants possess anticancer potential, only a limited number of plants are scientifically studied. Therefore, more scientific studies on anticancer MPs should be carried out; it may lead to discovering and isolating cost-effective and safe anticancer drugs.

show abstract

Section: Cancer Status In Ethiopiamentioning

confidence: 99%

Traditional and Phytochemical Bases of Herbs, Shrubs, Climbers, and Trees from Ethiopia for Their Anticancer Response

Abate

Tadesse²,

Bachheti

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…received both of Vitamins B9 (50 mg/kg/day using intragastric tube) [15] and B12 (15 μg/kg intraperitoneal twice a week) [16], and the fifth, diabetic group received Vitamins D, B9, and B12 as previously described.…”

Section: Experimental Protocolmentioning

confidence: 99%

Efficacy of Cosupplementation Therapy With Vitamins B9, B12, and D on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats

JOUFI

Bana

Tewfik

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: This study evaluated the effects of Vitamins D, B9, and B12 given individually or combined in ameliorating some biochemical parameters related to endothelial dysfunction in diabetic rats.Methods: A total of 50 Sprague-Dawley male rats were divided into five groups: Control, diabetic, diabetic received Vitamin D, diabetic received Vitamins B9 and B12, and diabetic received Vitamins B9, B12, and D. At the end of 6 weeks, the rats were sacrificed and a set of assays was carried out to determine: Fasting blood sugar (FBS), lipid profile, nitric oxide (NO), homocysteine (Hcy), malondialdehyde (MDA), and serum levels of Vitamins B9, B12, and D.Results: Diabetic rat received Vitamin D and diabetic rat received Vitamins B9 and B12 had a significant decline in the levels of FBS, lipid profile, and Hcy with reduced MDA (p<0.05) release but significant increase in NO level. On the same hand, diabetic rat received combined supplementation of Vitamins B9, B12, and D had more pronounced effect (p<0.00).Conclusion: Given these findings, the combined vitamins therapy had antiatherosclerotic effects by inhibiting lipid peroxidation and stimulating NO production, resulting in amelioration the endothelial dysfunction in diabetic rat.

show abstract

“…Oxygen homeostasis is an important factor for maintaining normal energy production. The kidney is one of the most easily damaged organs during hypoxia (Deniz et al, 2017;Wang et al, 2018). An increasing body of evidence suggests that chronic hypoxia can trigger a kidney damage response and may stimulate inflammation in proximal tubule cells, thereby causing irreversible pathological changes.…”

Section: Introductionmentioning

confidence: 99%

Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys

Kong

et al. 2021

Front. Physiol.

View full text Add to dashboard Cite

BackgroundHypoxia contributes to a cascade of inflammatory response mechanisms in kidneys that result in the development of renal interstitial fibrosis and subsequent chronic renal failure. Nonetheless, the kidney possesses a self-protection mechanism under a certain degree of hypoxia and this mechanism its adaptation to hypoxia. As the hypoxia-inducible factor (HIF)–vascular endothelial growth factor (VEGF) axis is a key pathway for neovascularization, the activation of this axis is a target for renal hypoxia therapies.MethodsSprague–Dawley rats were exposed to normobaric hypoxia and subdivided into three groups, namely group A (21% O2), group B (10% O2), and group C (7% O2). Renal tissue samples were processed and analyzed to determine pathological morphological changes, the expression of HIF, VEGF, inflammation factor and vascular density.ResultsWe found that as the duration of hypoxia increased, destructive changes in the kidney tissues became more severe in group C (7% O2). In contrast, the increased duration of hypoxia did not exacerbate kidney damage in group B (10% O2). As the hypoxia was prolonged and the degree of hypoxia increased, the expression of HIF-1α increased gradually. As hypoxia time increased, the expression of VEGF increased gradually, but VEGF expression in group B (10% O2) was the highest. Group C (7% O2) had higher levels of IL-6, IL-10, and TNF-alpha. Additionally, the highest vascular density was observed in group B.ConclusionThese findings suggest that activating the HIF–VEGF signaling pathway to regulate angiogenesis after infliction of hypoxic kidney injury may provide clues for the development of novel CKD treatments.

show abstract

Effects of folic acid on rat kidney exposed to 900 MHz electromagnetic radiation

Cited by 20 publications

References 60 publications

Traditional and Phytochemical Bases of Herbs, Shrubs, Climbers, and Trees from Ethiopia for Their Anticancer Response

Traditional and Phytochemical Bases of Herbs, Shrubs, Climbers, and Trees from Ethiopia for Their Anticancer Response

Efficacy of Cosupplementation Therapy With Vitamins B9, B12, and D on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats

Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys

Contact Info

Product

Resources

About