Effects of folic acid on oxidative damage of kidney in lead-exposed rats

Li, Ning; Wen, Liuding; Yu, Zengli; Li, Tiange; Wang, Tianlin; Qiao, Mingqiang; Luo, Song; Huang, Xianqing

doi:10.3389/fnut.2022.1035162

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…PN stimulates the activity of antioxidant enzymes such as superoxide dismutase, catalase, and others. It is a powerful scavenger of FRs and has beneficial effects to ameliorate OS status (Asbaghi et al, 2021, Li et al, 2022.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Peroxynitrite and Some Chemical Parameters in Sera of Hospital Cleaning Staffs

2023

ZJPAS

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The long periods of working hours at the hospital, and exposure to residues of harmful substances such as anticancer drugs and others lead to excessive formation of free radicals in the body. The aim of this study was to evaluate peroxynitrite, folic acid, homocysteine, ceruloplasmin, and copper in hospital cleaning worker staff (janitors) exposed to residue of different types of substances such as patients' blood, urine, and tools, as well as anticancer drugs in the work setting. This study was conducted among 40 subjects. Twenty subjects (from hospital cleaning staff) were considered hospital cleaning worker staff subjects, twenty other subjects were included as a healthy control group. The mean levels of peroxynitrite, folic acid, and ceruloplasmin in the hospital cleaning staff were (90.80± 23.93, 3.305±1.388, and 269.9±71.86) and in a healthy control group were (19.7±6.551, 6.232±1.738, and 129.88±37.98) µmol/L, respectively, which are statistically high significant. In contrast, the mean serum levels of homocysteine in two groups were (10.84±4.695 and 8.21±1.31) µmol/L, respectively, which are statistically significant. The average copper content was also found in both groups, although it was statistically insignificant and measured (129.34±.26.51) µg/dL in the hospital cleaning staff group and (133.91±11.25) µg/dL in the control group. These findings suggest that long-term exposure to residues of various types of substances in the work setting may cause an induced oxidative stress that results in a number of diseases including cancer.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Peroxynitrite and Some Chemical Parameters in Sera of Hospital Cleaning Staffs

2023

ZJPAS

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“…Over the long term, folate affects DNA methylation, in uencing the expression of genes related to monocyte function and lead toxicity [30]. Animal studies suggest that folate not only affects lead metabolism but also protects against lead-induced oxidative damage [31].…”

Section: Discussionmentioning

confidence: 99%

Association between folic acid levels and sarcopenia in American adults: evidence from NHANES

Qiao,

Xiang,

Shi

et al. 2024

Preprint

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Background Sarcopenia is associated with several health problems, and people with type 2 diabetes have a significantly increased risk.Nonetheless，it is unclear whether folic acid levels are associated with sarcopenia in individuals with type 2 diabetes.This study aims to investigate the relationship between serum and red blood cell folate levels and muscle mass，and the incidence of sarcopenia in American adults with diabetes，and to assess the mediating role of heavy metal levels. Methods This study involved 3，371 adult patients with diabetes，based on data gathered from the National Health and Nutrition Examination Survey(NHANES)between 1999 and 2018.Muscle mass was assessed using dual-energy X-ray absorptiometry(DXA)，and participants were grouped according to serum and red blood cell folate levels.Multivariable linear and logistic regression models were used to assess linear associations between folate levels and sarcopenia，while restricted cubic spline regression was used to assess non-linear associations.The role of heavy metals was assessed using mediation effect analysis. Results In diabetic men，higher levels of serum and red blood cell folate were linked to a greater muscle mass index ALMBMI and a lower incidence of sarcopenia.Blood lead levels were a partial mediator of the association between folate levels and sarcopenia.In women，there was no significant association found between folate levels and sarcopenia. Conclusions The study found that in American male diabetic patients, higher serum and red blood cell folate levels are associated with better muscle mass and a lower incidence of sarcopenia, with blood lead levels playing a partial mediating role. This suggests that folate might reduce the risk of sarcopenia by lowering levels of heavy metals, particularly lead, especially in male diabetic patients.Future studies should continue to investigate this correlation and its underlying mechanisms.

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Disturbance of oxidation/antioxidant status and histopathological damage in tsinling lenok trout under acute thermal stress

Ma²,

et al. 2023

Trop Anim Health Prod

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Effects of folic acid on oxidative damage of kidney in lead-exposed rats

Cited by 5 publications

References 53 publications

Evaluation of Peroxynitrite and Some Chemical Parameters in Sera of Hospital Cleaning Staffs

Evaluation of Peroxynitrite and Some Chemical Parameters in Sera of Hospital Cleaning Staffs

Association between folic acid levels and sarcopenia in American adults: evidence from NHANES

Disturbance of oxidation/antioxidant status and histopathological damage in tsinling lenok trout under acute thermal stress

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