Effects of food matrix elements (dietary fibres) on grapefruit peel flavanone profile and on faecal microbiota during in vitro fermentation

Tang, Rongxue; Yu, Haifei; Ruan, Zheng; Zhang, Li; Xue, Yan; Yuan, Xiaofeng; Qi, Miao; Yao, Yanbin

doi:10.1016/j.foodchem.2021.131065

Cited by 26 publications

(19 citation statements)

References 42 publications

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“…The phenolic components of CPP were analyzed by ultra-high performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS) coupled with electrospray ionization source (ESI) (Waters Corporation, Milford, MA, USA) mass spectrometry using the method of Tang et al [ 25 ] with some modifications. Chromatographic separation was performed on a chromatographic column (21 × 50 mm, Waters ACQUITY UPLC BEH C18).…”

Section: Methodsmentioning

confidence: 99%

The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD)

Zhang

Ruan

et al. 2021

Foods

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Gannan navel orange and Jinggang pomelo, belonging to the genus Citrus, are good sources of phenolic compounds, which are mainly concentrated in the peel. These phenolic compounds are considered promising in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). In order to maximize nutrients retention and bioactivity in the peel, pomelo peel and orange peel were processed using freeze-drying technology and mixed in the ratio (pomelo peel powder 50% and orange peel powder 50%) to make citrus peel powder (CPP). The purpose of this study was to explore new strategies and mechanisms associated with the consumption of CPP to alleviate nonalcoholic fatty liver injury, lipid metabolism disorders, and gut microbiota dysbiosis in obese mice induced by high-fat diet (HFD). The results showed that after 12 weeks of CPP administration, CPP supplementation had a strong inhibitory effect on HFD-induced weight gain, hepatic fat accumulation, dyslipidemia, and the release of pro-inflammatory cytokines. In particular, CPP modulates the composition of the intestinal flora, such as increasing the relative abundance of phylum Firmicutes, genus Faecalibaculum, genus Lactobacillus, genus Dubosiella, and genus Lachnospiraceae_NK4A136_ group and decreasing the relative abundance of phylum Bacteroidota, genus Helicobacter, and genus Bacteroides. These results suggest that CPP has a preventive effect on NAFLD, which can be related to the regulation of intestinal flora.

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Section: Methodsmentioning

confidence: 99%

The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD)

Zhang

Ruan

et al. 2021

Foods

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“…Previous studies have revealed that SDF alleviated hyperlipidemia by altering the gut microbiota; , however, whether SPDF with a high proportion of IDF possesses anti-hyperlipidemic activity is unknown. In addition, recent studies revealed that DF supplementation could increase the abundance of beneficial bacteria, including Clostridium leptum, Bifidobacterium , and Lactobacillus spp., to a greater extent in the in vitro colonic fermentation than grapefruit peel flavanones alone . Cloudy orange juice, retaining pomace fiber, was more effective than the clarified one in lowering postprandial glucose in men with increased cardiometabolic risk .…”

Section: Introductionmentioning

confidence: 85%

“…In addition, recent studies revealed that DF supplementation could increase the abundance of beneficial bacteria, including Clostridium leptum, Bif idobacterium, and Lactobacillus spp., to a greater extent in the in vitro colonic fermentation than grapefruit peel flavanones alone. 19 Cloudy orange juice, retaining pomace fiber, was more effective than the clarified one in lowering postprandial glucose in men with increased cardiometabolic risk. 20 These findings indicated that DF and flavonoids might have a synergistic health effect.…”

Section: ■ Introductionmentioning

confidence: 98%

Shatianyu (Citrus grandis L. Osbeck) Flavonoids and Dietary Fiber in Combination Are More Effective Than Individually in Alleviating High-Fat-Diet-Induced Hyperlipidemia in Mice by Altering Gut Microbiota

Deng

Zhang

Dong

et al. 2022

J. Agric. Food Chem.

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This study was aimed at exploring the separate and combined anti-hyperlipidemic effect of Shatianyu (Citrus grandis L. Osbeck) flavonoids (SPFEs) and DF (SPDF) on HFD-fed mice after 14-week administration in diet, together with the possible microbiota-mediated mechanisms. SPFEs and SPDF were more effective together than separately in improving serum lipid profiles, decreasing hepatic lipid accumulation, and upregulating the expression of hepatic CPT1a, CYP7A1, ABCG5, and ABCG8. Butyrate has been previously proved to have an anti-hyperlipidemic effect. The fecal butyrate contents were negatively correlative with serum/liver lipid but positively correlated with fecal total bile acids levels, and SPDF + SPFEs had the most fecal butyrate in this study. SPDF or SPFEs enriched microbiota related to acetic and propionic acids production, while SPDF + SPFEs also bloomed norank_f_Muribaculaceae, Dubosiella, Lachnoclostridium, and norank_f_Eubacterium_coprostanoligenes_group, which were positively correlated to fecal butyrate contents. Thus, SPFEs and SPDF might alleviate hyperlipidemia synergistically by regulating microbiota to produce butyrate, thereby regulating lipid metabolism.

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“…In addition, it is not only the natural food matrices that are essential [ 74 , 75 ], but also the preparation process and the conditions under which it is ingested (e.g., cooking, juicing, etc.). It has been widely demonstrated that cooking affects the phytochemical content of foods as well as their chemical structures and the bioavailability of their bioactive compounds; in other words, how a food is processed before consumption may be directly related to its health effects [ 76 , 77 , 78 , 79 , 80 , 81 ].…”

Section: Discussionmentioning

confidence: 99%

A Mixture of Pure, Isolated Polyphenols Worsens the Insulin Resistance and Induces Kidney and Liver Fibrosis Markers in Diet-Induced Obese Mice

et al. 2022

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Obesity is a worldwide epidemic with severe metabolic consequences. Polyphenols are secondary metabolites in plants and the most abundant dietary antioxidants, which possess a wide range of health effects. The most relevant food sources are fruit and vegetables, red wine, black and green tea, coffee, virgin olive oil, and chocolate, as well as nuts, seeds, herbs, and spices. The aim of this work was to evaluate the ability of a pure, isolated polyphenol supplementation to counteract the pernicious metabolic effects of a high-fat diet (HFD). Our results indicated that the administration of pure, isolated polyphenols under HFD conditions for 26 weeks worsened the glucose metabolism in diet-induced obese mice. The data showed that the main target organ for these undesirable effects were the kidneys, where we observed fibrotic, oxidative, and kidney-disease markers. This work led us to conclude that the administration of pure polyphenols as a food supplement would not be advisable. Instead, the ingestion of complete “whole” foods would be the best way to get the health effects of bioactive compounds such as polyphenols.

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Effects of food matrix elements (dietary fibres) on grapefruit peel flavanone profile and on faecal microbiota during in vitro fermentation

Cited by 26 publications

References 42 publications

The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD)

The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD)

Shatianyu (Citrus grandis L. Osbeck) Flavonoids and Dietary Fiber in Combination Are More Effective Than Individually in Alleviating High-Fat-Diet-Induced Hyperlipidemia in Mice by Altering Gut Microbiota

A Mixture of Pure, Isolated Polyphenols Worsens the Insulin Resistance and Induces Kidney and Liver Fibrosis Markers in Diet-Induced Obese Mice

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