2019
DOI: 10.5603/fm.a2018.0110
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Effects of formaldehyde on vascular endothelial growth factor, matrix metallopeptidase 2 and osteonectin levels in periodontal membrane and alveolar bone in rats

Abstract: Background: The objective of this study was to investigate whether long term formaldehyde inhalation may affect periodontal membrane and alveolar bone loss leading to periodontitis. The negative effects of formaldehyde were described using vascular endothelial growth factor (VEGF), matrix metallopeptidase 2 (MMP-2) and osteonectin antibodies involved in the extracellular matrix and angiogenetic development. Materials and methods: Thirty adult Wistar albino rats were used in this study. Rats were divided into t… Show more

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Cited by 5 publications
(4 citation statements)
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“…However, other investigations have indicated that pathophysiological changes occur with e-cig aerosols including oxidative stress, DNA damage, altered innate host responses, inflammation, cellular senescence, profibrinogenic and dysregulated repair that could contribute to oral disease including periodontitis 85 . Formaldehyde toxicity also was reported to disrupt the functions of the periodontium, including alveolar bone, and altered cell growth and remodeling factors in rats 89 . Finally, elevated levels of proinflammatory cytokines are detected in crevicular fluid of dental implants in cigarette and e-cig users 90 .…”
Section: E-cig (Ends) Effectsmentioning
confidence: 99%
“…However, other investigations have indicated that pathophysiological changes occur with e-cig aerosols including oxidative stress, DNA damage, altered innate host responses, inflammation, cellular senescence, profibrinogenic and dysregulated repair that could contribute to oral disease including periodontitis 85 . Formaldehyde toxicity also was reported to disrupt the functions of the periodontium, including alveolar bone, and altered cell growth and remodeling factors in rats 89 . Finally, elevated levels of proinflammatory cytokines are detected in crevicular fluid of dental implants in cigarette and e-cig users 90 .…”
Section: E-cig (Ends) Effectsmentioning
confidence: 99%
“…The new vessel formation by affecting angiogenesis is important for normal ossification [32]. Lacin et al [22] examined the effect of formaldaldehyde application on bone and observed a decrease in osteonectin expression after injury. Considering the association of osteonectin, a calcium-binding protein, involved in cell adhesion, it is suggested that osteonectin expression was increased in osteoblast and osteocyte cells due to tamoxifen effect which may stimulate the induction of bone remodelling.…”
Section: Discussionmentioning
confidence: 99%
“…Many contemporary studies describe the emission of formaldehyde mainly from three sources: the residual formaldehyde present in the resin, which is used as adhesives for wood-based panels, formaldehyde formed by the polycondensation reaction between hydroxymethyl groups and formaldehyde released by hydrolytic degradation of hardened resin, especially under conditions of increased humidity and increased temperature [ 16 ]. Despite its wide range of applications, formaldehyde belongs to hazard class 2 and belongs to carcinogens [ 17 ]. That is why the concentration of the substance should be constantly monitored, especially in the work area.…”
Section: Introductionmentioning
confidence: 99%