Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy

Karadaş, Barış; Kaya, Tijen; Çetin, Meral; Parlak, Ahmet; Durmuş, Nedim; Bağcıvan, İhsan; Gültürk, Sefa

doi:10.1016/j.vph.2006.12.002

Cited by 5 publications

(7 citation statements)

References 31 publications

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“…The pig placenta expresses b-adrenergic receptors, and b 1 -and b 2 -adrenergic agonists and antagonists regulate NaC transfer in pig placenta at least in vitro, implying that it can respond directly to b 2 -agonists (Sibley et al 1986). b 2 -Adrenergic agonists may also increase blood flow to the fetus, by acting on receptors in smooth muscle cells to elevate cAMP and cause vasodilation, as shown in human umbilical arteries in vitro (Karadas et al 2007). Finally, b 2 -adrenergic agonists alter metabolism, increasing skeletal muscle deposition in growing pigs (Dunshea et al 1993), and thus may increase nutrient availability for fetal growth, although we did not see changes in maternal or fetal plasma glucose or urea concentrations in response to maternal ractopamine in the present study.…”

Section: Discussionmentioning

confidence: 99%

Responses to maternal GH or ractopamine during early–mid pregnancy are similar in primiparous and multiparous pregnant pigs

Gatford

Blasio

Roberts

et al. 2009

Journal of Endocrinology

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Fetal growth is restricted in primiparous pigs (gilts) compared with dams who have had previous pregnancies (sows), as in other species. In gilts, daily maternal porcine GH (pGH) injections from day 25 to 50 of pregnancy (term w115 day) increase fetal growth and progeny muscularity, and responses in sows are unknown. Whether feeding the b 2 -adrenergic agonist ractopamine during this period increases progeny growth rates in either parity and fetal responses in gilts, have not been investigated. We hypothesised that fetal and placental growth and fetal muscle development would be increased more by maternal pGH and/or ractopamine during early-mid pregnancy in gilts than sows, since fetal growth is restricted in gilts causing lower birth weights. Large White! Landrace gilts and sows were injected daily with water (controls) or pGH (w15 mg/kg per day), or were fed 20 ppm ractopamine, between day 25 and 50 of pregnancy. Maternal pGH increased litter average fetal weight (11%, PZ0 . 007) and length (3%, PZ0 . 022), but not placental weight, at day 50 of pregnancy, irrespective of parity, and had the greatest effects in the heaviest fetuses of each litter. Maternal ractopamine increased average fetal weight (9%, PZ0 . 018), but not length. Muscle fiber diameter was increased by pGH in heavy littermates and by ractopamine in median littermates. Similar fetal growth responses to pGH and ractopamine in gilts and sows suggest that these hormones increase fetal nutrient availability similarly in both parities. We therefore predict that sustained pGH treatment will increase progeny birth weight, postnatal growth and survival, in both sows and gilts.

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Section: Discussionmentioning

confidence: 99%

Responses to maternal GH or ractopamine during early–mid pregnancy are similar in primiparous and multiparous pregnant pigs

Gatford

Blasio

Roberts

et al. 2009

Journal of Endocrinology

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“…This could be associated with the fact that sows receiving Rac and Arg both separately and together had a numeri-cally greater number of total piglets born. The greater number of total piglets born could be associated with a higher embryonic survival due a better nutrient flow originated by Arg and Rac supplementation (Bird et al, 2003;Karadas et al, 2007) and the redirection of nutrients toward protein synthesis by the Rac (Cantarelli et al, 2009). According to van der Lende and van Rens (2003), at approximately 100 d of gestation, fetal mortality can increase due to limited uterine space.…”

Section: Sow Performancementioning

confidence: 99%

Effects of ractopamine and arginine dietary supplementation for sows on growth performance and carcass quality of their progenies1

Garbossa

Júnior

Silveira

et al. 2015

Journal of Animal Science

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The objective of this study was to evaluate the effects of ractopamine (Rac) and Arg fed to pregnant sows from d 25 to 53 of gestation on fetal muscle development as well as the performance and carcass characteristics of the progeny. One hundred sows were divided into 4 treatments including a control diet, the control plus 1% Arg, the control plus 20 mg/kg Rac, and the control diet supplemented with both additives at the same levels as those used separately. During the farrowing process the data evaluated were the weight of placenta to calculate the placental efficiency and the number of piglets born alive, stillborn, and mummified. To evaluate the fiber number and area, 12 male piglets from each treatment were euthanized to harvest semitendinosus muscle. During the lactation, the preweaning mortality, weaned weights, and number of piglets weaned per litter were evaluated. After weaning, the pig performance was evaluated until the slaughter following the sow treatment. At end of finishing phase, 1 male pig of each treatment replicate was selected to evaluation the carcass and pork quality. All variables measured were analyzed using the MIXED procedure of SAS and least squares means were compared using the Tukey test with P < 0.05. The control diet + supplementation of 1.0% of L-Arg + 20 mg/kg of ractopamine HCl from d 25 to 53 of gestation (Arg+Rac) treatment had a greater number of stillborn piglets (P = 0.014) than the control group. Piglet birth weights from sows fed Rac were 11% greater (P = 0.031) than those of piglets of the control treatment. The semitendinosus muscle fiber diameters of piglets at birth from sows that received Arg, Rac, and Arg+Rac were greater (P < 0.0001) than those of control piglets, and as consequence, the fiber number per square millimeter decreased (P < 0.0001). The final nursery BW of progeny from sows fed Arg and Rac individually were greater (P = 0.010) than those of progeny of the control group. At 110 d of age, in the beginning of the finisher 1 phase, pigs from Arg-fed sows were 1.9 kg heavier (P = 0.010) than pigs from the Arg+Rac-fed sows. The HCW were 2.97 and 1.64 kg heavier (P < 0.0001) for progeny of the Arg and Rac sows, respectively, compared with those of progeny of the control. In conclusion, the trial showed that the use of Rac for gestating sows increased the piglets' weight at birth. The size of muscular fiber was increased in the semitendinosus muscle of piglets originating from sows receiving Rac or Arg. However, the combination of both compounds did not have an additive effect in comparison with the control treatment but increased the stillbirth number.

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“…This hypothesis is supported by the fact that fenoterol-and BRL37344-induced relaxations were partly reduced due to the attenuation of cAMP levels, suggesting that ß 2 -and ß 3 -AR agonists may have considerable future pharmaceutical implications in the clinical management of pregnancyrelated disorders (eg, preterm labor) or other conditions (eg, intrauterine growth restrictions) in which improvement in fetoplacental exchanges may be of interest [33].…”

Section: Hypertensionmentioning

confidence: 91%

“…In human umbilical arteries, formoterol-and BRL37344-induced relaxations were mediated by a mixed population of ß 2/3 -AR through cAMP increases [33]. Nevertheless, it is important to note that the authors used endotheliumdenuded artery rings, whereas many studies performed in human and animal models suggest a preferential endothelial location of ß 3 -AR.…”

Section: ß 3 -Adrenoceptors In Blood Vesselsmentioning

confidence: 99%

Beta-3 Adrenoceptors as New Therapeutic Targets for Cardiovascular Pathologies

Gauthier

Rozec

Manoury

et al. 2011

Curr Heart Fail Rep

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Catecholamines play a key role in the regulation of cardiovascular function, classically through ß(1/2)-adrenoreceptors (AR) activation. After ß(3)-AR cloning in the late 1980s, convincing evidence for ß(3)-AR expression and function in cardiovascular tissues recently initiated a reexamination of their involvement in the pathophysiology of cardiovascular diseases. Their upregulation in diseased cardiovascular tissues and resistance to desensitization suggest they may be attractive therapeutic targets. They may substitute for inoperant ß(1/2)-AR to mediate vasodilation in diabetic or atherosclerotic vessels. In cardiac ventricle, their contractile effects are functionally antipathetic to those of ß(1/2)-AR; in normal heart, ß(3)-ARs may mediate a moderate negative inotropic effect, but in heart failure, it may protect against adverse effects of excessive catecholamine stimulation by action on excitation-contraction coupling, electrophysiology, or remodelling. Thus, prospective studies in animals and patients at different stages of heart failure should lead to identify the best therapeutic window to use ß(3)-AR agonists and/or antagonists.

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Effects of formoterol and BRL 37344 on human umbilical arteries in vitro in normotensive and pre-eclamptic pregnancy

Cited by 5 publications

References 31 publications

Responses to maternal GH or ractopamine during early–mid pregnancy are similar in primiparous and multiparous pregnant pigs

Responses to maternal GH or ractopamine during early–mid pregnancy are similar in primiparous and multiparous pregnant pigs

Effects of ractopamine and arginine dietary supplementation for sows on growth performance and carcass quality of their progenies1

Beta-3 Adrenoceptors as New Therapeutic Targets for Cardiovascular Pathologies

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