Effects of four inorganic lead compounds on the proliferation and junctional coupling of cultured REL liver cells

Apostoli, Pietro; Huard, Carine; Chaumontet, Catherine; Martel, Paule Latino; Alessio, L; Mazzoleni, Giovanna

doi:10.1002/1097-0274(200009)38:3<340::aid-ajim15>3.0.co;2-s

Cited by 12 publications

(5 citation statements)

References 19 publications

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“…For most heavy metals, there have been reports which indicate that the bioavailability of a metal and, in consequence, its toxic effect, is affected by its physicochemical form and the resulting solubility in water [17,18,19]. The results indicated that solubility in water was not the main factor which affected toxicity of cadmium compounds.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Toxic Potency of Selected Cadmium Compounds on A549 and CHO-9 Cells

Zapór¹

2014

International Journal of Occupational Safety and Ergonomics

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Toxic Potency of Selected Cadmium Compounds on A549 and CHO-9 Cells

Zapór¹

2014

International Journal of Occupational Safety and Ergonomics

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“…18,24 However, these highly localized and short-term approaches cannot ensure actual biocompatibility over long-term periods, with genotoxic, metabolic, and clinical systems. [26][27][28][29][30] First, generally, heavy metal ion uptake-related symptoms do not occur directly or rapidly during a temporary exposure. 26,[31][32][33][34][35] Second, cell proliferation/adhesion are not seriously affected by surficial compositions, other than surficial topographies.…”

Section: Apl Mater 5 074102 (2017)mentioning

confidence: 99%

“…[21][22][23][26][27][28][29][30]72,73,78 To further directly inspect the chronological/clinical effects of bioimplanted piezoceramics, we are currently conducting biochemistry studies and long-term epidemiologic investigations using canine/porcine models.…”

Section: Apl Mater 5 074102 (2017)mentioning

confidence: 99%

“…27,28 Additionally, compounds containing Pb, e.g., lead oxides, are also classified as hazardous materials because they have been implicated in diverse diseases, including tumors. 29,30 For instance, there is very famous and unequivocal historical evidence that widespread Pb usage in the Roman Empire, and the popular lead cosmetics of the Middle Ages, over long periods of time contributed to critical social decline. [31][32][33] For these reasons, US Food & Drug Administration (FDA), Centers for Disease Control & Prevention (CDC), and Restriction of Hazardous Substances Directive (RoHS) have issued negative findings regarding lead-related materials and devices.…”

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confidence: 99%

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Comprehensive biocompatibility of nontoxic and high-output flexible energy harvester using lead-free piezoceramic thin film

et al. 2017

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Flexible piezoelectric energy harvesters have been regarded as an overarching candidate for achieving self-powered electronic systems for environmental sensors and biomedical devices using the self-sufficient electrical energy. In this research, we realize a flexible high-output and lead-free piezoelectric energy harvester by using the aerosol deposition method and the laser lift-off process. We also investigated the comprehensive biocompatibility of the lead-free piezoceramic device using ex-vivo ionic elusion and in vivo bioimplantation, as well as in vitro cell proliferation and histologic inspection. The fabricated LiNbO3-doped (K,Na)NbO3 (KNN) thin film-based flexible energy harvester exhibited an outstanding piezoresponse, and average output performance of an open-circuit voltage of ∼130 V and a short-circuit current of ∼1.3 μA under normal bending and release deformation, which is the best record among previously reported flexible lead-free piezoelectric energy harvesters. Although both the KNN and Pb(Zr,Ti)O3 (PZT) devices showed short-term biocompatibility in cellular and histological studies, excessive Pb toxic ions were eluted from the PZT in human serum and tap water. Moreover, the KNN-based flexible energy harvester was implanted into a porcine chest and generated up to ∼5 V and 700 nA from the heartbeat motion, comparable to the output of previously reported lead-based flexible energy harvesters. This work can compellingly serve to advance the development of piezoelectric energy harvesting for actual and practical biocompatible self-powered biomedical applications beyond restrictions of lead-based materials in long-term physiological and clinical aspects.

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“…Liver tissue is the largest repository (33%) of lead among the soft tissues (Agency for Toxic Substances and Disease Registry, 2007). Several lines of evidence suggest that lead mediates hepatotoxicity through various mechanisms, including effects on hepatic drug-metabolizing enzymes, hepatic necrosis (Sivaprasad et al, 2004;Berrahal et al, 2009), abnormal liver function (Al-Neamy et al, 2001) and liver cell proliferation through the enhanced expression of tumor necrosis factor-alpha (TNF-a; Kubo et al, 1996;Shinozuka et al, 1996;Apostoli et al, 2000). Lead also mediates hepatotoxicity through the induction of cellular oxidative stress (Aykin-Burns et al, 2003;Sivaprasad et al, 2004;Berrahal et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Lead inhibits paraoxonase 2 but not paraoxonase 1 activity in human hepatoma HepG2 cells

Sukketsiri

Porntadavity

Phivthong-ngam

et al. 2012

J of Applied Toxicology

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Lead is an environmental toxicant of great concern for humans and animals. Lead-induced liver damage and malfunction are partly due to a disturbance of the cellular antioxidant balance. Paraoxonase 1 (PON1) and PON2 are highly expressed in the liver and have been proposed as antioxidative enzymes. In this study, the effects of lead on PON1 and PON2 activities were investigated in human hepatoma HepG2 cells by exposing the cells to various concentrations of lead acetate for 24, 48, or 72 h. The results show that a significant increase in reactive oxygen species was observed even at the lowest concentration of lead treatment. However, only the highest concentration of lead significantly influenced cell viability. Lead had no influence on cell-associated PON1 activity, but it significantly decreased cytoplasmic PON2 activity in a concentration- and time-dependent manner. This reduction was rescued by the addition of calcium. A significant increase of PON2 transcript was observed by real-time polymerase chain reaction, while PON2 protein expression did not change in the western blot analysis. Taken together, these results indicate that lead reduces PON2, but not PON1, activity and that this reduction is reversed by calcium. Lead-induced oxidative stress and decreased PON2 activity lead to the upregulation of PON2 transcript.

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Effects of four inorganic lead compounds on the proliferation and junctional coupling of cultured REL liver cells

Cited by 12 publications

References 19 publications

Evaluation of the Toxic Potency of Selected Cadmium Compounds on A549 and CHO-9 Cells

Evaluation of the Toxic Potency of Selected Cadmium Compounds on A549 and CHO-9 Cells

Comprehensive biocompatibility of nontoxic and high-output flexible energy harvester using lead-free piezoceramic thin film

Lead inhibits paraoxonase 2 but not paraoxonase 1 activity in human hepatoma HepG2 cells

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