Effects of free fatty acids on sodium currents in rat dorsal root ganglion neurons

Hong, Min-Pyo; Kim, Hong Im; Shin, Yong Kyoo; Lee, Chung Soo; Park, Mijung; Song, Jin-Ho

doi:10.1016/j.brainres.2004.02.033

Cited by 30 publications

(28 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3). The physiological and pharmacological functions of DHA which support our proposal include 1) an antiinflammatory effect via the suppression of the arachidonic acid cascade, 32) 2) inhibition of voltage-gated sodium channels, 33,34) 3) agonistic action toward transient receptor potential vanilloid 1 (TRPV1) that is closely associated with the onset of inflammation, 35) and 4) inhibition of calcium channels. 33,36) Furthermore, we have elucidated that one of the actions contributing to the antinociceptive mechanisms of DHA is not performed directly on the opioid receptor, but indirectly through the release of an endogenous opioid peptide b-endorphin 37) (Figs.…”

Section: N-3 Pufas and Painsupporting

confidence: 68%

Unsaturated Fatty Acids and Pain

Tokuyama

Nakamoto

2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Fatty acids, which are the essential nutrients for humans, are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a range of biological phenomena. Recently, an increasing number of physiologic and pharmacologic reports on fatty acids have improved our understanding of the association of fatty acids with certain diseases. It has also become apparent that functional properties of fatty acids are modulated by factors such as the amount of individual fatty acid intake and their distribution among organs. Recently, the functional relationship between polyunsaturated fatty acids and pain has been the focus of many studies. Both basic and clinical studies have shown that a dietary intake of n-3 series polyunsaturated fatty acids results in a reduction in the pain associated with rheumatoid arthritis, dysmenorrhea, inflammatory bowl disease, and neuropathy. In addition, levels of n-6 series polyunsaturated fatty acids are high in patients with chronic pain. These results indicate that polyunsaturated fatty acids play a vital role in pain regulation. In this review, we summarize a number of basic and clinical studies on polyunsaturated fatty acids and their association with pain.

show abstract

Section: N-3 Pufas and Painsupporting

confidence: 68%

Unsaturated Fatty Acids and Pain

Tokuyama

Nakamoto

2011

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…One main hypothesis put forward to explain the beneficial effect is PUFA-induced inhibition of cardiac sodium and calcium channels (41)(42)(43)(44)(45)(46). Some studies also describe shortening of the cardiac action potential on PUFA administration (47,48).…”

Section: Discussionmentioning

confidence: 99%

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I _Ks channel

Liin

Ejneby

Barro-Soria

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

238

View full text Add to dashboard Cite

Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as IKs channel modulators. We report that PUFAs open Kv7.1 via an electrostatic mechanism. Both the polyunsaturated acyl tail and the negatively charged carboxyl head group are required for PUFAs to open Kv7.1. We further show that KCNE1 coexpression abolishes the PUFA effect on Kv7.1 by promoting PUFA protonation. PUFA analogs with a decreased pKa value, to preserve their negative charge at neutral pH, restore the sensitivity to open IKs channels. PUFA analogs with a positively charged head group inhibit IKs channels. These different PUFA analogs could be developed into drugs to treat cardiac arrhythmias. In support of this possibility, we show that PUFA analogs act antiarrhythmically in embryonic rat cardiomyocytes and in isolated perfused hearts from guinea pig.

show abstract

“…Previous studies have also provided contradicting indications on whether only PUFAs dampen excitability or if also monounsaturated fatty acids act anti-excitable (Bendahhou et al 1997;Voskuyl et al 1998;Hong et al 2004;Taha et al 2010b;Bandero et al 2013;Taha et al 2013). Oleic acid (Fig.…”

mentioning

confidence: 99%

“…For instance, PUFAs inactivate neuronal voltage-gated Na + and Ca 2+ channels (Vreugdenhil et al 1996;Hong et al 2004), and thereby dampen neuronal activity. Despite the important role of K + channels for excitability, the effect of PUFAs on neuronal voltage-gated K + (K V ) channels is less explored and has shown ambiguous results (Gubitosi-Klug et al 1995;Villarroel & Schwarz 1996;Holmqvist et al 2001;Boland & Drzewiecki 2008).…”

Section: Introductionmentioning

confidence: 99%

Polyunsaturated fatty acids are potent openers of human M‐channels expressed in Xenopus laevis oocytes

et al. 2016

View full text Add to dashboard Cite

Methods: Effects of fatty acids and fatty-acid analogues on mouse dorsal root ganglion neurons and on the human K V 7.2/3 channel expressed in Xenopus laevis oocytes were studied using electrophysiology. Conclusions: These findings suggest that circulating polyunsaturated fatty acids, with a minimum requirement of multiple double bonds and a charged carboxyl group, dampen excitability by opening neuronal M-channels. Collectively, our data bring light to the molecular targets of polyunsaturated fatty acids and thus a possible mechanism by which polyunsaturated fatty acids reduce neuronal excitability. Results

show abstract

Effects of free fatty acids on sodium currents in rat dorsal root ganglion neurons

Cited by 30 publications

References 33 publications

Unsaturated Fatty Acids and Pain

Unsaturated Fatty Acids and Pain

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I _Ks channel

Polyunsaturated fatty acids are potent openers of human M‐channels expressed in Xenopus laevis oocytes

Contact Info

Product

Resources

About

Effects of free fatty acids on sodium currents in rat dorsal root ganglion neurons

Cited by 30 publications

References 33 publications

Unsaturated Fatty Acids and Pain

Unsaturated Fatty Acids and Pain

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I Ks channel

Polyunsaturated fatty acids are potent openers of human M‐channels expressed in Xenopus laevis oocytes

Contact Info

Product

Resources

About

Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac I _Ks channel