Effects of Frequency and Duration of Interrupting Sitting on Cardiometabolic Risk Markers

Abstract

Interrupting prolonged sitting with short multiple bouts of moderate-intensity physical activity (PA) can improve postprandial cardiometabolic risk markers. This study examined the effect of high and low frequency PA bouts (matched for total PA duration and energy expenditure) on postprandial cardiometabolic responses when compared with prolonged sitting. In this three-condition randomised crossover trial, 14 sedentary, inactive females (33.8±13.4 years, BMI 27.1±6.3 kg/m2) completed 3, 7.5 h conditions: 1) prolonged sitting (SIT), 2) high-frequency PA breaks (HIGH-FREQ) consisting of 15 ×2 min bouts of moderate-intensity treadmill PA every 30 min, and 3) low-frequency PA breaks (LOW-FREQ) consisting of 3 ×10 min bouts of moderate-intensity treadmill PA every 180 min. The PA bouts were performed at 65% of peak oxygen uptake. Net incremental area under the curve (iAUC) for each 7.5 h condition was calculated for glucose, insulin and triacylglycerol (TAG) concentrations. Insulin iAUC was significantly (p<0.026) lower during HIGH-FREQ (mean [95%CI]; 82.86 [55.02, 110.70] µU/mL∙7.5 h) than LOW-FREQ (116.61 [88.50, 144.73] µU/mL∙7.5 h) and SIT (119.98 [92.42, 147.53] µU/mL∙7.5 h). Glucose and TAG iAUC did not differ between conditions. Engaging in higher-frequency PA breaks may be effective in attenuating postprandial insulin responses compared with lower-frequency PA breaks and prolonged sitting.

The Effect of an Atherogenic Diet and Acute Hyperglycaemia on Endothelial Function in Rabbits Is Artery Specific

“…p < 0.05 was considered statistically significant, trends were reported when p = 0.05-0.099, and >0.099 was considered not significant (n/s). Effect sizes are commonly used to study the clinical relevance of an intervention and show the magnitude of the effect that it is producing [31][32][33]. The Cohen's d (d) equation was used to examine the magnitude of the effect of the high glucose incubations on blood vessel relaxation and immunohistochemistry results.…”

Undercarboxylated osteocalcin has no adverse effect on endothelial function in rabbit aorta or human vascular cells

“…Trends were reported if p was between 0.05 and 0.09. Effect sizes are commonly used to study the clinical relevance of intervention and show the magnitude of the effect that it is producing (Maylor, Zakrzewski‐Fruer, Stensel, Orton, & Bailey, 2019; Rodevand et al, 2019; Silva, Lacerda, & da Mota, 2019). The Cohen's d ( d ) equation was used to examine the magnitude of effect.…”

Effects of interrupting sitting with different activity bouts on postprandial lipemia: A randomized crossover trial

“…Sedentary behavior has been reported to be unfavorably associated with chronic disease' risk factors, such as high triglycerides (TGs), 2 obesity, 3 and metabolic syndrome 4 . Experimental studies refer to a variety of patterns (different frequency, duration, and intensity of activity bouts) for interrupting prolonged sitting 8‐14 ; however, there are very few studies that have compared different patterns. One review reported that EE is not the sole component of exercise that moderates postprandial lipidemia 19 .…”

“…Experimental studies refer to a variety of patterns (different frequency, duration, and intensity of activity bouts) for interrupting prolonged sitting. Previous studies have used 1.5‐8‐min breaks of light‐ or moderate‐to‐vigorous intensity activities every 15‐85 minutes 8‐14 and have focused mainly on the treatment effects of a pattern of interrupting prolonged sitting relative to prolonged sitting or continuous exercise. There are very few studies that have compared different patterns, and the necessity and value of further research on this topic are warranted for making recommendations on sedentary behavior 15 …”