Effects of Frictional Stimulation on the Structure of the Stratum Corneum

Mackenzie, Ian C.

doi:10.1007/978-3-642-68682-5_17

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Potential Mechanisms Underlying Ai-hfsr1

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Cited by 2 publications

(2 citation statements)

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“…Mackenzie 18 proposed that the cells of the stratum corneum were less differentiated after mechanical stimulation due to an increase in the rate of keratinocyte proliferation. The increases in the suprabasal nucleated cell population and number of cell layers in the stratum corneum suggest that keratinocyte turnover time may be shortened.…”

Section: Discussionmentioning

confidence: 99%

Callus formation is associated with hyperproliferation and incomplete differentiation of keratinocytes, and increased expression of adhesion molecules

Kim¹,

Kim²,

Choi³

et al. 2010

British Journal of Dermatology

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Section: Discussionmentioning

confidence: 99%

Callus formation is associated with hyperproliferation and incomplete differentiation of keratinocytes, and increased expression of adhesion molecules

Kim¹,

Kim²,

Choi³

et al. 2010

British Journal of Dermatology

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“…Furthermore, since the speed of cell proliferation has been significantly accelerated, there is not enough time for the proliferating keratinocytes to fully differentiate and become mature. Consequently, part of the regenerated keratinocytes is incompletely differentiated, and thereafter parakeratosis or dyskeratosis occurs (43)(44)(45). All the characteristics mentioned above are actually consistent with the histologic manifestations of AI-HFSR.…”

Section: Potential Mechanisms Underlying Ai-hfsrmentioning

confidence: 60%

Apatinib-Induced Hand–Foot Skin Reaction in Chinese Patients With Liver Cancer

et al. 2021

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Apatinib, an anti-tumor drug selectively targeting VEGFR2 (Vascular Endothelia Growth Factor Recpetor-2), has been proven effective in Chinese patients with liver cancer. Generally, treatment with apatinib achieves 16.1% of the overall objective remission rate (ORR) and 55.83% of the disease control rate (DCR) in Chinese patients with liver cancer. However, the prevalence of apatinib-induced hand–foot skin reaction (AI-HFSR) is noticeably high. The incidence of AI-HFSR is about 50.5%, of which Grades 1/2 and 3 are 38.8 and 11.6%, respectively. In addition, potential molecular mechanisms underlying the development of AI-HFSR are poorly understood and urgently needed to be investigated histologically. In this review, we summarize and review the current efficacy of apatinib and the prevalence of AI-HFSR in Chinese patients with liver cancer. Besides, we postulate the potential mechanisms underlying the development of AI-HFSR and discuss the optimal clinical management for this unwanted cutaneous side effect.

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Effects of Frictional Stimulation on the Structure of the Stratum Corneum

Cited by 2 publications

References 14 publications

Callus formation is associated with hyperproliferation and incomplete differentiation of keratinocytes, and increased expression of adhesion molecules

Callus formation is associated with hyperproliferation and incomplete differentiation of keratinocytes, and increased expression of adhesion molecules

Apatinib-Induced Hand–Foot Skin Reaction in Chinese Patients With Liver Cancer

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