Effects of fructo-oligosaccharides and Bacillus licheniformis on performance, nutrient digestibility, hematological properties, and organ development in weaned piglets

Abstract

Context Weaning is a critical period for piglets, often associated with reduced growth performance and increased susceptibility to diseases. Dietary supplements such as fructo-oligosaccharides (FOS) and Bacillus licheniformis (BL) may improve piglet health and performance during this transition. Aims To investigate the effects of dietary FOS and BL supplementation, individually and in combination, on growth performance, health status, nutrient digestibility, hematological parameters, and organ development in weaned piglets. Methods In total, 240 weaned piglets were allocated into the following six treatments: control, 0.2% FOS, 0.4% FOS, BL, 0.2% FOS + BL, and 0.4% FOS + BL. Growth performance, morbidity rates, nutrient digestibility, blood parameters, and organ indices were evaluated over the experimental period. Key results The 0.4% FOS + BL group showed significant improvements in feed conversion ratio, reduced morbidity rates, enhanced nutrient digestibility (crude protein, crude fiber, and phosphorus), increased total protein, albumin, and albumin:globulin ratio, reduced blood urea nitrogen, improved white blood cell and lymphocyte counts, and enhanced spleen and pancreatic organ indices. BL supplementation distinctively influenced liver-enzyme profiles, suggesting metabolic adaptation rather than hepatic stress. Blood urea nitrogen was reduced in BL and 0.4% FOS + BL groups. Conclusions Dietary supplementation with 0.4% FOS and BL synergistically benefited weaned piglets by improving growth performance, enhancing feed efficiency, and reducing morbidity rates. This treatment also enhanced nutrient utilization, positively affected blood parameters, and promotes the development of spleen and pancreatic organs. Implications The combination of 0.4% FOS and BL shows potential as an effective feed-additive strategy to enhance growth and immune responses in weaned piglets, potentially reducing the need for antibiotics and promoting sustainable pig production.