Effects of fructose consumption on food intake and biochemical and body parameters in Wistar rats

Ramos, Viviane Wagner; Batista, Leandro Oliveira; Albuquerque, Kelse Tibau de

doi:10.1016/j.repce.2017.04.009

Cited by 10 publications

(16 citation statements)

References 20 publications

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“…[20,21] On the contrary, some studies were explained that fructose intake did not directly increase body weight. [22,23] Similar to the studies of Ramos et al [22] and Castro et al [23] , we observed that the body weight values were not changed with fructose intake. It is known that THC has the regulatory effect on body weight and food intake.…”

Section: Discussionsupporting

confidence: 90%

“…On the contrary, some studies were explained that fructose intake did not directly increase body weight . Similar to the studies of Ramos et al . and Castro et al ,.…”

Section: Discussionsupporting

confidence: 74%

“…Studies indicated that fructose consumption may be associated with weight gain and causes to the development of obesity . On the contrary, some studies were explained that fructose intake did not directly increase body weight . Similar to the studies of Ramos et al .…”

Section: Discussionsupporting

confidence: 62%

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The protective effects of Δ9-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia

Beydogan

Coşkun

Bolkent

2019

Journal of Pharmacy and Pharmacology

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Objectives A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Δ9‐tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to investigate the effects of THC treatment on inflammation, lipid profiles and oxidative stress in rat liver with hyperinsulinemia. Methods Sprague‐Dawley rats were divided into groups: control, fructose (10% fructose in drinking water for 12 weeks), THC (1.5 mg/kg/day for the last 4 weeks, intraperitoneally) and fructose+THC groups. Biochemical parameters were measured spectrophotometrically. ELISA method was used for insulin measurement. Apoptosis and inflammation markers were detected by the streptavidin‐biotin peroxidase method. Key findings The consumptions of food and fluid are inversely proportional to fructose and non‐fructose groups. Insulin levels were the highest in fructose group. The reduced glutathione‐S‐transferase level significantly increased in fructose + THC group compared with fructose group. Total cholesterol level in the fructose + THC group was higher than the fructose group. Caspase‐3 and NF‐κβ immunopositive cell numbers increased in fructose + THC rats compared with fructose group. The number of IL‐6 immunopositive cell decreased in fructose + THC group compared with fructose group. Conclusions According to the result, long‐term and low‐dose THC administration may reduce hyperinsulinemia and inflammation in rats to some extent.

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Section: Discussionsupporting

confidence: 90%

“…On the contrary, some studies were explained that fructose intake did not directly increase body weight . Similar to the studies of Ramos et al . and Castro et al ,.…”

Section: Discussionsupporting

confidence: 74%

See 1 more Smart Citation

The protective effects of Δ9-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia

Beydogan

Coşkun

Bolkent

2019

Journal of Pharmacy and Pharmacology

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“…These findings are in agreement with Ramos et al who reported that the consumption of 20% fructose diet for 8 weeks had no effect of body mass gain but caused increased visceral adiposity. 33 Ramos et al contended that the observed increase in adiposity without a concomitant increase in body mass to be a consequence of the high adipogenic and low energetic nature of fructose. 33 We therefore speculate that the observed dichotomy between the body mass and visceral adiposity in the current study is a result of the low energy efficiency of fructose.…”

mentioning

confidence: 99%

“…33 Ramos et al contended that the observed increase in adiposity without a concomitant increase in body mass to be a consequence of the high adipogenic and low energetic nature of fructose. 33 We therefore speculate that the observed dichotomy between the body mass and visceral adiposity in the current study is a result of the low energy efficiency of fructose. b-sitosterol and fenofibrate had no effect on body mass gain in the current study ( Fig.…”

mentioning

confidence: 99%

β-Sitosterol Shows Potential to Protect Against the Development of High-Fructose Diet-Induced Metabolic Dysfunction in Female Rats

Gumede

Lembede

Brooksbank

et al. 2020

Journal of Medicinal Food

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Metabolic syndrome (MetS) is a combination of risk factors that include insulin resistance, obesity, dyslipidemia, and hypertension. The consumption of high-fructose diets contributes to the development of MetS. b-sitosterol a naturally occurring phytosterol possesses antiobesogenic and antidiabetic effects. This study evaluated the potential protective effect of b-sitosterol against the development of metabolic dysfunction in growing female rats fed a high-fructose diet, mimicking children fed obesogenic diets. Thirty-five 21-day-old female Sprague Dawley rat pups were randomly allocated to and administered the following treatments: group 1-standard rat chow (SRC) + plain drinking water (PW) + plain gelatine cube (PC); group 2-SRC + 20% w/w fructose solution (FS) as drinking fluid + PC; group 3-SRC + FS + 100 mg/kg fenofibrate in gelatine cubes; group 4-SRC + FS + 20 mg/kg b-sitosterol gelatine cube (Bst); and group 5-SRC + PW + Bst. Following 12 weeks of feeding, the rats were fasted overnight, weighed, and then euthanized. Plasma cholesterol, insulin, glucose, triglyceride, and adiponectin concentrations were determined. Visceral fat was dissected out and weighed. The highfructose diet increased (P < .05) visceral adiposity and plasma triglyceride concentration but decreased (P < .05) plasma adiponectin concentration. b-sitosterol prevented the high-fructose diet-induced visceral obesity, hypertriglyceridemia, and hypoadiponectinemia. b-sitosterol alone increased plasma adiponectin concentration and reduced plasma insulin concentration and homeostatic model assessment index. In conclusion, b-sitosterol could be potentially used to prevent highfructose diet-induced metabolic dysfunction.

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Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

Alshuniaber

Alshammari

Eleawa

et al. 2022

Pharmaceutical Biology

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Context Camel milk is used in traditional medicine to treat diabetes mellitus hypertension and other metabolic disorders. Objective This study evaluated the antisteatotic and antihypertensive effects of camel milk protein hydrolysate (CMH) in high fructose (HF)-fed rats and compared it with the effects afforded by the intact camel milk protein extract (ICM). Materials and methods Adult male Wistar rats were divided into 6 groups ( n = 8 each) as 1) control, 2) ICM (1000 mg/kg), 3) CMH (1000 mg/kg), 4) HF (15% in drinking water), 5) HF (15%) + ICM (1000 mg/kg), and 6) HF (15%) + CMH (1000 mg/kg). All treatments were given orally for 21 weeks, daily. Results Both ICM and CMH reduced fasting glucose and insulin levels, serum and hepatic levels of cholesterol and triglycerides, and serum levels of ALT and AST, angiotensin II, ACE, endothelin-1, and uric acid in HF-fed rats. In addition, both ICM and CMH reduced hepatic fat deposition in the hepatocytes and reduced hepatocyte damage. This was associated with an increase in the hepatic activity of AMPK, higher PPARα mRNA, reduced expression of fructokinase C, SREBP1, SREBP2, fatty acid synthase, and HMG-CoA-reductase. Both treatments lowered systolic and diastolic blood pressure. However, the effects of CMH on all these parameters were greater as compared to ICM. Discussion and conclusions The findings of this study encourage the use of CMH in a large-scale population and clinical studies to treat metabolic steatosis and hypertension.

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Effects of fructose consumption on food intake and biochemical and body parameters in Wistar rats

Cited by 10 publications

References 20 publications

The protective effects of Δ9-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia

The protective effects of Δ9-tetrahydrocannabinol against inflammation and oxidative stress in rat liver with fructose-induced hyperinsulinemia

β-Sitosterol Shows Potential to Protect Against the Development of High-Fructose Diet-Induced Metabolic Dysfunction in Female Rats

Camel milk protein hydrosylate alleviates hepatic steatosis and hypertension in high fructose-fed rats

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