Effects of fucoidans and heparin on reactions of neutrophils induced by IL-8 and C5a

Liewert, Inga; Ehrig, Karina; Alban, Susanne

doi:10.1016/j.carbpol.2017.02.051

Cited by 13 publications

(4 citation statements)

References 44 publications

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“…Previously, we showed that the used algae SP exhibit a multitude of effects relevant for both anti-inflammatory and antimetastatic activities including targets like chemokines, growth factors, adhesion molecules, complement factors, and extracellular matrix degrading enzymes. ,,,,− The concert of multiple actions is thought to contribute to the in vivo anti-inflammatory and antimetastatic activity of these algae SP. ,,, …”

Section: Resultsmentioning

confidence: 99%

Degradation of Eight Sulfated Polysaccharides Extracted from Red and Brown Algae and Its Impact on Structure and Pharmacological Activities

Lahrsen

Schoenfeld

Alban

2019

ACS Biomater. Sci. Eng.

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Degradation represents a strategy to improve the biopharmaceutical properties of native algae sulfated polysaccharides (SP) with high M w. The aim of this study was to compare the degradability of four sulfated xylogalactans (SXG) and four fucose-rich sulfated polysaccharides (FRSP) extracted from red and brown algae, respectively, using three simple methods causing no desulfation as well as to examine the chemical and pharmacological changes of the resulting fractions. The achieved degradation proved to be dependent on the basic glycan structure of the SP. Treatment with hydrogen peroxide (3%, 4 h, 50 °C) led to the most efficient degradation of both FRSP and SXG. The M w decrease was associated with distinct reduction of the activities (complement inhibition (>) elastase inhibition > C1-INH potentiation) and resulted in a modified pharmacological profile. Despite their much lower degree of sulfation, some of the fractions with M w < 15 kDa exhibited similar or even stronger activities than heparins, whereas they had only weak anticoagulant effects.

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Section: Resultsmentioning

confidence: 99%

Degradation of Eight Sulfated Polysaccharides Extracted from Red and Brown Algae and Its Impact on Structure and Pharmacological Activities

Lahrsen

Schoenfeld

Alban

2019

ACS Biomater. Sci. Eng.

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“…Fucoidan reduced the interleukin (IL) 8-and C5a-induced intracellular calcium release, ERK1/2 phosphorylation, and chemotaxis of polymorphonuclear neutrophils in a concentration-dependent manner. 35 Fucoidan has been shown to have anti-inflammatory effects by inhibiting the IL-1, hypoxia-inducible factor 1a/ vascular endothelial growth factor C, phosphoinositide 3-kinase/Akt/mammalian target of rapamycin, and NF-kB signaling pathways. 16,36 Fucoidan suppressed p65 phosphorylation and nuclear translocation as well as that of p38-MAPK and phosphoinositide 3-kinase-Akt.…”

Section: Discussionmentioning

confidence: 99%

Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor κB activation

Tsai

Wang

Liao

et al. 2018

Journal of Vascular Surgery

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“…Further, interleukin-10 (IL-10) secretions were seen in LPS-induced RAW 264.7 cells and [5] NO release and inducible NO synthase (iNOS) were inhibited by the SP fraction at a high dose at 200 μg/mL. To further understand the possible mechanism of the action of fucoidan on its elicited inflammatory response, fucoidan from brown algae Saccharina latissimi and Fucus versiculosus [6] were tested on polymorphonuclear neutrophils (PMN) and their ability to bind to the target proteins closely linked to the anti-inflammatory process. Both fucoidans isolated in the algae showed affinity on both IL-8 and C5a with a higher affinity on the former.…”

Section: Pharmacologic Potential Activities Of Spsmentioning

confidence: 99%

Pharmacologic Application Potentials of Sulfated Polysaccharide from Marine Algae

Manlusoc

Hsieh

et al. 2019

Polymers

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With the advent of exploration in finding new sources for treating different diseases, one possible natural source is from marine algae. Having an array of potential benefits, researchers are interested in the components which comprise one of these activities. This can lead to the isolation of active compounds with biological activities, such as antioxidation of free radicals, anti-inflammation, antiproliferation of cancer cells, and anticoagulant to name a few. One of the compounds that are isolated from marine algae are sulfated polysaccharides (SPs). SPs are complex heterogenous natural polymers with an abundance found in different species of marine algae. Marine algae are known to be one of the most important sources of SPs, and depending on the species, its chemical structure varies. This variety has important physical and chemical components and functions which has gained the attention of researchers as this contributes to the many facets of its pharmacologic activity. In this review, recent pharmacologic application potentials and updates on the use of SPs from marine algae are discussed.

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Effects of fucoidans and heparin on reactions of neutrophils induced by IL-8 and C5a

Cited by 13 publications

References 44 publications

Degradation of Eight Sulfated Polysaccharides Extracted from Red and Brown Algae and Its Impact on Structure and Pharmacological Activities

Degradation of Eight Sulfated Polysaccharides Extracted from Red and Brown Algae and Its Impact on Structure and Pharmacological Activities

Fucoidan attenuates angiotensin II-induced abdominal aortic aneurysms through the inhibition of c-Jun N-terminal kinase and nuclear factor κB activation

Pharmacologic Application Potentials of Sulfated Polysaccharide from Marine Algae

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