Effects of Full‐Mouth Scaling and Root Planing in Conjunction With Systemically Administered Azithromycin

Gomi, Kazuhiro; Yashima, Akihiro; Nagano, Takatoshi; Kanazashi, Mikimoto; Maeda, Nobuyo; Arai, Takashi

doi:10.1902/jop.2007.060247

Cited by 99 publications

(150 citation statements)

References 32 publications

(75 reference statements)

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“…Most researchers have focused on the use of AZM in the treatment of chronic periodontitis (Gomi et al, 2007;Haffajee et al, 2007Haffajee et al, , 2008Mascarenhas et al, 2005;Morozumi et al, 2010;Oteo et al, 2010;Plaza et al, 2003;Pradeep et al, 2008;Sampaio et al, 2011;Smith et al, 2002;Yashima et al, 2009). To the best of our knowledge, only one clinical trial has used AZM in the treatment of aggressive periodontitis (Haas et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Azithromycin: A new concept in adjuvant treatment of periodontitis

Muniz

Oliveira

Carvalho

et al. 2013

European Journal of Pharmacology

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In most patients periodontitis is successfully treated by scaling and root planing, but some studies have shown that certain sites continue to show periodontal tissue destruction despite conventional periodontal therapy. To solve this problem, antibiotics may be administered as an adjuvant treatment. This includes azithromycin (AZM), which is effective against Gram-negative aerobic and anaerobic bacteria and has a long half-life in periodontal tissues. The purpose of the present study was to determine the efficacy of azithromycin as an adjuvant treatment for periodontitis through a review of the literature in Medline, Lilacs and Scielo, combining the keywords "azithromycin", "periodontal treatment" and "periodontitis" in both Portuguese and English languages. To be included, articles had to be clinical trials, randomized, controlled, double-blind or blind, and published between 2001 and 2011. 70 articles were found, of which 12 were selected based on title and abstract. Most studies used AZM as an adjuvant treatment for chronic periodontitis, usually in a single daily dose of 500 mg over three days, and indicated that AZM significantly reduced probing depth and increased periodontal attachment when compared to controls. Furthermore, a reduction in red and orange complex and an increase in bacteria associated with healthy periodontal conditions were observed in subjects treated with AZM. It may be concluded that the use of AZM as an adjuvant treatment for periodontitis improves clinical and microbiological parameters when compared to conventional treatment alone.

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Section: Resultsmentioning

confidence: 99%

Azithromycin: A new concept in adjuvant treatment of periodontitis

Muniz

Oliveira

Carvalho

et al. 2013

European Journal of Pharmacology

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“…The study investigators reported on 6 major groups of antimicrobials: amoxicillin and metronidazole combination therapy, 18,44,45,47,50,55,60 metronidazole, 39,52,61 erythromycin analogues (azithromycin 39,46,49,51,[56][57][58][59] and clarithromycin 53 ), moxifloxacin 48 (a fourth-generation fluoroquinolone antibacterial agent), and others (for example, tetracycline 20,43,54 and doxycycline 22,48,62 as the antimicrobial dose of doxycycline, not to be confused with SDD, which is covered in a separate section). The variety of dosing regimens used for each systemic antimicrobial drug is described elsewhere.…”

Section: Moderatementioning

confidence: 99%

“…Compared with SRP alone, SRP plus systemic antimicrobials resulted in a 0.35-mm mean gain in CAL (95% CI, 0.20-0.51) ( Figure 5). 18,20,22,39,[43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] We judged the overall level of certainty in the evidence to be moderate on the basis of the evidence profile in Table 3.…”

Section: Moderatementioning

confidence: 99%

Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts

Smiley¹,

Tracy²,

Abt³

et al. 2015

The Journal of the American Dental Association

231

199

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“…Several systemic antibiotics or antibiotic combinations have been used as an adjunct therapy in the treatment of chronic periodontitis, such as the use of AMX, MTZ, DOX, and AZM. 35,26,37,55 For non-smokers, several studies have shown clinical benefits, such as a reduction of PD and a CAL gain, to using systemic antibiotic therapy associated with non-surgical therapy. 56,57,58 However, the variability of dosing, frequency, time of use, and choice of antibiotics led to a consideration of the need to establish protocols for an effective therapy.…”

mentioning

confidence: 99%

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

et al. 2017

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The aim of this study was to perform a systematic review and meta-analysis to examine the effect of systemic antibiotics in the periodontal treatment of smokers. The selection criteria were as follows: controlled randomized clinical trials; studies published in English; studies with smoker patients diagnosed with chronic periodontitis; patients without systemic diseases; studies that used systemic antibiotic therapy associated with periodontal treatment; studies that presented results for the test and control groups and assessments of clinical periodontal parameters, such as probing depth (PD), bleeding on probing (BOP), and clinical attachment level (CAL). The differences in average weights were calculated with a confidence interval (CI) of 95% for PD reduction, CAL gain and BOP. The means of the periodontal clinical parameters were compared between the baseline and post-treatment periods between the test groups and the control groups. The heterogeneity was assessed using the Cochran Q test (Q (df = 3), α = 5%). A total of 67 articles were found, and after the selection process, three randomized controlled trials were included in the meta-analysis. The results indicate that SRP associated with systemic antibiotics promoted additional benefits when compared to SRP alone, with a greater reduction of PD (p = 0.0359, CI = -0.42, -0.01) and a gain of CAL (p = 0.0161, CI = -0.39, -0.04). There was a modest PD reduction (PD, DM -0.21) and a modest CAL gain (CAL, DM -0.22). The results of our meta-analysis reveal the clinical benefits of systemic antibiotics as an adjunct to the non-surgical periodontal treatment of smokers. These clinical improvements, although statistically significant, appeared to be of little clinical relevance.

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Effects of Full‐Mouth Scaling and Root Planing in Conjunction With Systemically Administered Azithromycin

Abstract: It was shown that full-mouth SRP using systemically administered azithromycin was a clinically and bacteriologically useful basic periodontal treatment for severe chronic periodontitis.

Cited by 99 publications

References 32 publications

Azithromycin: A new concept in adjuvant treatment of periodontitis

Azithromycin: A new concept in adjuvant treatment of periodontitis

Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts

Antibiotic therapy as an adjunct to scaling and root planing in smokers: a systematic review and meta-analysis

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